$Association of free fatty acid binding protein with central aortic stiffness, myocardial dysfunction and preserved ejection fraction heart failure$
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Association of free fatty acid binding protein with central aortic stiffness, myocardial dysfunction and preserved ejection fraction heart failure

Abstract There is an established link between cardiometabolic abnormality, central arterial stiffness, and preserved ejection fraction heart failure (HFpEF). Adipocyte free fatty acid binding protein (a-FABP) has been shown to signal endothelial dysfunction through fatty acid toxicity, though its ro...

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Autores principales:	Chih-Hsuan Yen, Jiun-Lu Lin, Kuo-Tzu Sung, Cheng-Huang Su, Wen-Hung Huang, Yun-Yu Chen, Shih-Chieh Chien, Yau-Huei Lai, Ping-Ying Lee, Yen-Yu Liu, Jui-Peng Tsai, Cheng-Ting Tsai, Charles Jia-Yin Hou, Ying-Ju Chen, Yu-Jou Hsieh, Chung-Lieh Hung, Ta-Chuan Hung, Hung-I. Yeh
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e5c7e0b1a1cd47e1b650497b3c8f0d2e
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spelling	oai:doaj.org-article:e5c7e0b1a1cd47e1b650497b3c8f0d2e2021-12-02T18:50:51ZAssociation of free fatty acid binding protein with central aortic stiffness, myocardial dysfunction and preserved ejection fraction heart failure10.1038/s41598-021-95534-12045-2322https://doaj.org/article/e5c7e0b1a1cd47e1b650497b3c8f0d2e2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95534-1https://doaj.org/toc/2045-2322Abstract There is an established link between cardiometabolic abnormality, central arterial stiffness, and preserved ejection fraction heart failure (HFpEF). Adipocyte free fatty acid binding protein (a-FABP) has been shown to signal endothelial dysfunction through fatty acid toxicity, though its role in mediating ventricular-arterial dysfunction remains unclear. We prospectively examined the associations of a-FABP with central arterial pressure using non-invasive applanation tonometry (SphygmoCor) and cardiac structure/function (i.e., tissue Doppler imaging [TDI] and global longitudinal myocardial strain [GLS]) in patients with cardiometabolic (CM) risk (n = 150) and HFpEF (n = 50), with healthy volunteers (n = 49) serving as a control. We observed a graded increase of a-FABP across the healthy controls, CM individuals, and HFpEF groups (all paired p < 0.05). Higher a-FABP was independently associated with higher central systolic and diastolic blood pressures (CSP/CPP), increased arterial augmentation index (Aix), lower early myocardial relaxation velocity (TDI-e′), higher left ventricle (LV) filling (E/TDI-e′) and worsened GLS (all p < 0.05). During a median of 3.85 years (interquartile range: 3.68–4.62 years) follow-up, higher a-FABP (cutoff: 24 ng/mL, adjusted hazard ratio: 1.01, 95% confidence interval: 1.001–1.02, p = 0.04) but not brain natriuretic peptide, and higher central hemodynamic indices were related to the incidence of heart failure (HF) in fully adjusted Cox models. Furthermore, a-FABP improved the HF risk classification over central hemodynamic information. We found a mechanistic pathophysiological link between a-FABP, central arterial stiffness, and myocardial dysfunction. In a population with a high metabolic risk, higher a-FABP accompanied by worsened ventricular-arterial coupling may confer more unfavorable outcomes in HFpEF.Chih-Hsuan YenJiun-Lu LinKuo-Tzu SungCheng-Huang SuWen-Hung HuangYun-Yu ChenShih-Chieh ChienYau-Huei LaiPing-Ying LeeYen-Yu LiuJui-Peng TsaiCheng-Ting TsaiCharles Jia-Yin HouYing-Ju ChenYu-Jou HsiehChung-Lieh HungTa-Chuan HungHung-I. YehNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Chih-Hsuan Yen Jiun-Lu Lin Kuo-Tzu Sung Cheng-Huang Su Wen-Hung Huang Yun-Yu Chen Shih-Chieh Chien Yau-Huei Lai Ping-Ying Lee Yen-Yu Liu Jui-Peng Tsai Cheng-Ting Tsai Charles Jia-Yin Hou Ying-Ju Chen Yu-Jou Hsieh Chung-Lieh Hung Ta-Chuan Hung Hung-I. Yeh Association of free fatty acid binding protein with central aortic stiffness, myocardial dysfunction and preserved ejection fraction heart failure
description	Abstract There is an established link between cardiometabolic abnormality, central arterial stiffness, and preserved ejection fraction heart failure (HFpEF). Adipocyte free fatty acid binding protein (a-FABP) has been shown to signal endothelial dysfunction through fatty acid toxicity, though its role in mediating ventricular-arterial dysfunction remains unclear. We prospectively examined the associations of a-FABP with central arterial pressure using non-invasive applanation tonometry (SphygmoCor) and cardiac structure/function (i.e., tissue Doppler imaging [TDI] and global longitudinal myocardial strain [GLS]) in patients with cardiometabolic (CM) risk (n = 150) and HFpEF (n = 50), with healthy volunteers (n = 49) serving as a control. We observed a graded increase of a-FABP across the healthy controls, CM individuals, and HFpEF groups (all paired p < 0.05). Higher a-FABP was independently associated with higher central systolic and diastolic blood pressures (CSP/CPP), increased arterial augmentation index (Aix), lower early myocardial relaxation velocity (TDI-e′), higher left ventricle (LV) filling (E/TDI-e′) and worsened GLS (all p < 0.05). During a median of 3.85 years (interquartile range: 3.68–4.62 years) follow-up, higher a-FABP (cutoff: 24 ng/mL, adjusted hazard ratio: 1.01, 95% confidence interval: 1.001–1.02, p = 0.04) but not brain natriuretic peptide, and higher central hemodynamic indices were related to the incidence of heart failure (HF) in fully adjusted Cox models. Furthermore, a-FABP improved the HF risk classification over central hemodynamic information. We found a mechanistic pathophysiological link between a-FABP, central arterial stiffness, and myocardial dysfunction. In a population with a high metabolic risk, higher a-FABP accompanied by worsened ventricular-arterial coupling may confer more unfavorable outcomes in HFpEF.
format	article
author	Chih-Hsuan Yen Jiun-Lu Lin Kuo-Tzu Sung Cheng-Huang Su Wen-Hung Huang Yun-Yu Chen Shih-Chieh Chien Yau-Huei Lai Ping-Ying Lee Yen-Yu Liu Jui-Peng Tsai Cheng-Ting Tsai Charles Jia-Yin Hou Ying-Ju Chen Yu-Jou Hsieh Chung-Lieh Hung Ta-Chuan Hung Hung-I. Yeh
author_facet	Chih-Hsuan Yen Jiun-Lu Lin Kuo-Tzu Sung Cheng-Huang Su Wen-Hung Huang Yun-Yu Chen Shih-Chieh Chien Yau-Huei Lai Ping-Ying Lee Yen-Yu Liu Jui-Peng Tsai Cheng-Ting Tsai Charles Jia-Yin Hou Ying-Ju Chen Yu-Jou Hsieh Chung-Lieh Hung Ta-Chuan Hung Hung-I. Yeh
author_sort	Chih-Hsuan Yen
title	Association of free fatty acid binding protein with central aortic stiffness, myocardial dysfunction and preserved ejection fraction heart failure
title_short	Association of free fatty acid binding protein with central aortic stiffness, myocardial dysfunction and preserved ejection fraction heart failure
title_full	Association of free fatty acid binding protein with central aortic stiffness, myocardial dysfunction and preserved ejection fraction heart failure
title_fullStr	Association of free fatty acid binding protein with central aortic stiffness, myocardial dysfunction and preserved ejection fraction heart failure
title_full_unstemmed	Association of free fatty acid binding protein with central aortic stiffness, myocardial dysfunction and preserved ejection fraction heart failure
title_sort	association of free fatty acid binding protein with central aortic stiffness, myocardial dysfunction and preserved ejection fraction heart failure
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e5c7e0b1a1cd47e1b650497b3c8f0d2e
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Association of free fatty acid binding protein with central aortic stiffness, myocardial dysfunction and preserved ejection fraction heart failure

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