Identification of a subset of immunosuppressive P2RX1-negative neutrophils in pancreatic cancer liver metastasis

Identification of a subset of immunosuppressive P2RX1-negative neutrophils in pancreatic cancer liver metastasis

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive metastatic disease characterized by an immunosuppressive microenvironment. Here the authors show that a subset of P2RX1-negative neutrophils with immunosuppressive properties accumulate in PDAC metastatic liver tissues and promote tumor...

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Autores principales: Xu Wang, Li-Peng Hu, Wei-Ting Qin, Qin Yang, De-Yu Chen, Qing Li, Kai-Xia Zhou, Pei-Qi Huang, Chun-Jie Xu, Jun Li, Lin-Li Yao, Ya-Hui Wang, Guang-Ang Tian, Jian-Yu Yang, Min-Wei Yang, De-Jun Liu, Yong-Wei Sun, Shu-Heng Jiang, Xue-Li Zhang, Zhi-Gang Zhang
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Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/e5c9f48dd02248afa64c33593ecd5868
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spelling oai:doaj.org-article:e5c9f48dd02248afa64c33593ecd58682021-12-02T15:16:22ZIdentification of a subset of immunosuppressive P2RX1-negative neutrophils in pancreatic cancer liver metastasis10.1038/s41467-020-20447-y2041-1723https://doaj.org/article/e5c9f48dd02248afa64c33593ecd58682021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20447-yhttps://doaj.org/toc/2041-1723Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive metastatic disease characterized by an immunosuppressive microenvironment. Here the authors show that a subset of P2RX1-negative neutrophils with immunosuppressive properties accumulate in PDAC metastatic liver tissues and promote tumor growth.Xu WangLi-Peng HuWei-Ting QinQin YangDe-Yu ChenQing LiKai-Xia ZhouPei-Qi HuangChun-Jie XuJun LiLin-Li YaoYa-Hui WangGuang-Ang TianJian-Yu YangMin-Wei YangDe-Jun LiuYong-Wei SunShu-Heng JiangXue-Li ZhangZhi-Gang ZhangNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Xu Wang
Li-Peng Hu
Wei-Ting Qin
Qin Yang
De-Yu Chen
Qing Li
Kai-Xia Zhou
Pei-Qi Huang
Chun-Jie Xu
Jun Li
Lin-Li Yao
Ya-Hui Wang
Guang-Ang Tian
Jian-Yu Yang
Min-Wei Yang
De-Jun Liu
Yong-Wei Sun
Shu-Heng Jiang
Xue-Li Zhang
Zhi-Gang Zhang
Identification of a subset of immunosuppressive P2RX1-negative neutrophils in pancreatic cancer liver metastasis
description Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive metastatic disease characterized by an immunosuppressive microenvironment. Here the authors show that a subset of P2RX1-negative neutrophils with immunosuppressive properties accumulate in PDAC metastatic liver tissues and promote tumor growth.
format article
author Xu Wang
Li-Peng Hu
Wei-Ting Qin
Qin Yang
De-Yu Chen
Qing Li
Kai-Xia Zhou
Pei-Qi Huang
Chun-Jie Xu
Jun Li
Lin-Li Yao
Ya-Hui Wang
Guang-Ang Tian
Jian-Yu Yang
Min-Wei Yang
De-Jun Liu
Yong-Wei Sun
Shu-Heng Jiang
Xue-Li Zhang
Zhi-Gang Zhang
author_facet Xu Wang
Li-Peng Hu
Wei-Ting Qin
Qin Yang
De-Yu Chen
Qing Li
Kai-Xia Zhou
Pei-Qi Huang
Chun-Jie Xu
Jun Li
Lin-Li Yao
Ya-Hui Wang
Guang-Ang Tian
Jian-Yu Yang
Min-Wei Yang
De-Jun Liu
Yong-Wei Sun
Shu-Heng Jiang
Xue-Li Zhang
Zhi-Gang Zhang
author_sort Xu Wang
title Identification of a subset of immunosuppressive P2RX1-negative neutrophils in pancreatic cancer liver metastasis
title_short Identification of a subset of immunosuppressive P2RX1-negative neutrophils in pancreatic cancer liver metastasis
title_full Identification of a subset of immunosuppressive P2RX1-negative neutrophils in pancreatic cancer liver metastasis
title_fullStr Identification of a subset of immunosuppressive P2RX1-negative neutrophils in pancreatic cancer liver metastasis
title_full_unstemmed Identification of a subset of immunosuppressive P2RX1-negative neutrophils in pancreatic cancer liver metastasis
title_sort identification of a subset of immunosuppressive p2rx1-negative neutrophils in pancreatic cancer liver metastasis
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/e5c9f48dd02248afa64c33593ecd5868
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