Hto, Tritiated Amino Acid Exposure and External Exposure Induce Differential Effects on Hematopoiesis and Iron Metabolism

Abstract The increased potential for tritium releases from either nuclear reactors or from new facilities raises questions about the appropriateness of the current ICRP and WHO recommendations for tritium exposures to human populations. To study the potential toxicity of tritium as a function of dos...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jean-Marc Bertho, Dimitri Kereselidze, Line Manens, Cécile Culeux, Victor Magneron, Joel Surette, Melinda Blimkie, Linsdey Bertrand, Heather Wyatt, Maâmar Souidi, Isabelle Dublineau, Nicholas Priest, Jean-René Jourdain
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e5c9f935749c4522a3a3f433ac2bc1ee
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e5c9f935749c4522a3a3f433ac2bc1ee
record_format	dspace
spelling	oai:doaj.org-article:e5c9f935749c4522a3a3f433ac2bc1ee2021-12-02T13:34:55ZHto, Tritiated Amino Acid Exposure and External Exposure Induce Differential Effects on Hematopoiesis and Iron Metabolism10.1038/s41598-019-56453-42045-2322https://doaj.org/article/e5c9f935749c4522a3a3f433ac2bc1ee2019-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-56453-4https://doaj.org/toc/2045-2322Abstract The increased potential for tritium releases from either nuclear reactors or from new facilities raises questions about the appropriateness of the current ICRP and WHO recommendations for tritium exposures to human populations. To study the potential toxicity of tritium as a function of dose, including at a regulatory level, mice were chronically exposed to tritium in drinking water at one of three concentrations, 10 kBq.l−1, 1 MBq.l−1 or 20 MBq.l−1. Tritium was administered as either HTO or as tritiated non-essential amino acids (TAA). After one month’s exposure, a dose-dependent decrease in red blood cells (RBC) and iron deprivation was seen in all TAA exposed groups, but not in the HTO exposed groups. After eight months of exposure this RBC decrease was compensated by an increase in mean globular volume - suggesting the occurrence of an iron deficit-associated anemia. The analysis of hematopoiesis, of red blood cell retention in the spleen and of iron metabolism in the liver, the kidneys and the intestine suggested that the iron deficit was due to a decrease in iron absorption from the intestine. In contrast, mice exposed to external gamma irradiation at equivalent dose rates did not show any change in red blood cell numbers, white blood cell numbers or in the plasma iron concentration. These results showed that health effects only appeared following chronic exposure to concentrations of tritium above regulatory levels and the effects seen were dependent upon the speciation of tritium.Jean-Marc BerthoDimitri KereselidzeLine ManensCécile CuleuxVictor MagneronJoel SuretteMelinda BlimkieLinsdey BertrandHeather WyattMaâmar SouidiIsabelle DublineauNicholas PriestJean-René JourdainNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-20 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jean-Marc Bertho Dimitri Kereselidze Line Manens Cécile Culeux Victor Magneron Joel Surette Melinda Blimkie Linsdey Bertrand Heather Wyatt Maâmar Souidi Isabelle Dublineau Nicholas Priest Jean-René Jourdain Hto, Tritiated Amino Acid Exposure and External Exposure Induce Differential Effects on Hematopoiesis and Iron Metabolism
description	Abstract The increased potential for tritium releases from either nuclear reactors or from new facilities raises questions about the appropriateness of the current ICRP and WHO recommendations for tritium exposures to human populations. To study the potential toxicity of tritium as a function of dose, including at a regulatory level, mice were chronically exposed to tritium in drinking water at one of three concentrations, 10 kBq.l−1, 1 MBq.l−1 or 20 MBq.l−1. Tritium was administered as either HTO or as tritiated non-essential amino acids (TAA). After one month’s exposure, a dose-dependent decrease in red blood cells (RBC) and iron deprivation was seen in all TAA exposed groups, but not in the HTO exposed groups. After eight months of exposure this RBC decrease was compensated by an increase in mean globular volume - suggesting the occurrence of an iron deficit-associated anemia. The analysis of hematopoiesis, of red blood cell retention in the spleen and of iron metabolism in the liver, the kidneys and the intestine suggested that the iron deficit was due to a decrease in iron absorption from the intestine. In contrast, mice exposed to external gamma irradiation at equivalent dose rates did not show any change in red blood cell numbers, white blood cell numbers or in the plasma iron concentration. These results showed that health effects only appeared following chronic exposure to concentrations of tritium above regulatory levels and the effects seen were dependent upon the speciation of tritium.
format	article
author	Jean-Marc Bertho Dimitri Kereselidze Line Manens Cécile Culeux Victor Magneron Joel Surette Melinda Blimkie Linsdey Bertrand Heather Wyatt Maâmar Souidi Isabelle Dublineau Nicholas Priest Jean-René Jourdain
author_facet	Jean-Marc Bertho Dimitri Kereselidze Line Manens Cécile Culeux Victor Magneron Joel Surette Melinda Blimkie Linsdey Bertrand Heather Wyatt Maâmar Souidi Isabelle Dublineau Nicholas Priest Jean-René Jourdain
author_sort	Jean-Marc Bertho
title	Hto, Tritiated Amino Acid Exposure and External Exposure Induce Differential Effects on Hematopoiesis and Iron Metabolism
title_short	Hto, Tritiated Amino Acid Exposure and External Exposure Induce Differential Effects on Hematopoiesis and Iron Metabolism
title_full	Hto, Tritiated Amino Acid Exposure and External Exposure Induce Differential Effects on Hematopoiesis and Iron Metabolism
title_fullStr	Hto, Tritiated Amino Acid Exposure and External Exposure Induce Differential Effects on Hematopoiesis and Iron Metabolism
title_full_unstemmed	Hto, Tritiated Amino Acid Exposure and External Exposure Induce Differential Effects on Hematopoiesis and Iron Metabolism
title_sort	hto, tritiated amino acid exposure and external exposure induce differential effects on hematopoiesis and iron metabolism
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/e5c9f935749c4522a3a3f433ac2bc1ee
work_keys_str_mv	AT jeanmarcbertho htotritiatedaminoacidexposureandexternalexposureinducedifferentialeffectsonhematopoiesisandironmetabolism AT dimitrikereselidze htotritiatedaminoacidexposureandexternalexposureinducedifferentialeffectsonhematopoiesisandironmetabolism AT linemanens htotritiatedaminoacidexposureandexternalexposureinducedifferentialeffectsonhematopoiesisandironmetabolism AT cecileculeux htotritiatedaminoacidexposureandexternalexposureinducedifferentialeffectsonhematopoiesisandironmetabolism AT victormagneron htotritiatedaminoacidexposureandexternalexposureinducedifferentialeffectsonhematopoiesisandironmetabolism AT joelsurette htotritiatedaminoacidexposureandexternalexposureinducedifferentialeffectsonhematopoiesisandironmetabolism AT melindablimkie htotritiatedaminoacidexposureandexternalexposureinducedifferentialeffectsonhematopoiesisandironmetabolism AT linsdeybertrand htotritiatedaminoacidexposureandexternalexposureinducedifferentialeffectsonhematopoiesisandironmetabolism AT heatherwyatt htotritiatedaminoacidexposureandexternalexposureinducedifferentialeffectsonhematopoiesisandironmetabolism AT maamarsouidi htotritiatedaminoacidexposureandexternalexposureinducedifferentialeffectsonhematopoiesisandironmetabolism AT isabelledublineau htotritiatedaminoacidexposureandexternalexposureinducedifferentialeffectsonhematopoiesisandironmetabolism AT nicholaspriest htotritiatedaminoacidexposureandexternalexposureinducedifferentialeffectsonhematopoiesisandironmetabolism AT jeanrenejourdain htotritiatedaminoacidexposureandexternalexposureinducedifferentialeffectsonhematopoiesisandironmetabolism
_version_	1718392767279792128

Hto, Tritiated Amino Acid Exposure and External Exposure Induce Differential Effects on Hematopoiesis and Iron Metabolism

Ejemplares similares