Decreased peripheral perfusion measured by perfusion index is a novel indicator for cardiovascular death in patients with type 2 diabetes and established cardiovascular disease

Abstract Cardiovascular disease (CVD) is still the major cause of mortality in patients with type 2 diabetes. Despite of recent therapies, mortality and resources spent on healthcare due to CVD is still important problem. Thus, appropriate markers are needed to predict poor outcomes. Therefore, we i...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Hiroshi Okada, Muhei Tanaka, Takashi Yasuda, Yuki Okada, Hisahiro Norikae, Tetsuya Fujita, Takashi Nishi, Hirokazu Oyamada, Tetsuro Yamane, Michiaki Fukui
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e5ca39c781b54ec58ac6b629abe0d97e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e5ca39c781b54ec58ac6b629abe0d97e
record_format	dspace
spelling	oai:doaj.org-article:e5ca39c781b54ec58ac6b629abe0d97e2021-12-02T15:23:47ZDecreased peripheral perfusion measured by perfusion index is a novel indicator for cardiovascular death in patients with type 2 diabetes and established cardiovascular disease10.1038/s41598-021-81702-w2045-2322https://doaj.org/article/e5ca39c781b54ec58ac6b629abe0d97e2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81702-whttps://doaj.org/toc/2045-2322Abstract Cardiovascular disease (CVD) is still the major cause of mortality in patients with type 2 diabetes. Despite of recent therapies, mortality and resources spent on healthcare due to CVD is still important problem. Thus, appropriate markers are needed to predict poor outcomes. Therefore, we investigated the role of peripheral perfusion as an indicator for cardiovascular death in patients with type 2 diabetes and established CVD. This retrospective cohort study included 1080 patients with type 2 diabetes and history of CVD recruited from the outpatient clinic at Matsushita Memorial Hospital in Osaka, Japan. Peripheral perfusion is assessed using the perfusion index (PI), which represents the level of circulation through peripheral tissues. The median age and PI values were 74 years (range: 67–79 years) and 2.6% (range: 1.1–4.3%), respectively. During follow-up duration, 60 patients died due to CVD. The adjusted Cox regression analysis demonstrated that the risk of developing cardiovascular death was higher in the first quartile (Hazard ratio, 6.23; 95% CI, 2.28 to 22.12) or second quartile (Hazard ratio, 3.04; 95% CI, 1.46 to 6.85) of PI than that in the highest quartile (fourth quartile) of PI. PI (per 1% decrease) was associated with the development of cardiovascular death (Hazard ratio, 1.39; 95% CI, 1.16 to 1.68). PI could be a novel indicator of cardiovascular death in patients with type 2 diabetes and established CVD.Hiroshi OkadaMuhei TanakaTakashi YasudaYuki OkadaHisahiro NorikaeTetsuya FujitaTakashi NishiHirokazu OyamadaTetsuro YamaneMichiaki FukuiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hiroshi Okada Muhei Tanaka Takashi Yasuda Yuki Okada Hisahiro Norikae Tetsuya Fujita Takashi Nishi Hirokazu Oyamada Tetsuro Yamane Michiaki Fukui Decreased peripheral perfusion measured by perfusion index is a novel indicator for cardiovascular death in patients with type 2 diabetes and established cardiovascular disease
description	Abstract Cardiovascular disease (CVD) is still the major cause of mortality in patients with type 2 diabetes. Despite of recent therapies, mortality and resources spent on healthcare due to CVD is still important problem. Thus, appropriate markers are needed to predict poor outcomes. Therefore, we investigated the role of peripheral perfusion as an indicator for cardiovascular death in patients with type 2 diabetes and established CVD. This retrospective cohort study included 1080 patients with type 2 diabetes and history of CVD recruited from the outpatient clinic at Matsushita Memorial Hospital in Osaka, Japan. Peripheral perfusion is assessed using the perfusion index (PI), which represents the level of circulation through peripheral tissues. The median age and PI values were 74 years (range: 67–79 years) and 2.6% (range: 1.1–4.3%), respectively. During follow-up duration, 60 patients died due to CVD. The adjusted Cox regression analysis demonstrated that the risk of developing cardiovascular death was higher in the first quartile (Hazard ratio, 6.23; 95% CI, 2.28 to 22.12) or second quartile (Hazard ratio, 3.04; 95% CI, 1.46 to 6.85) of PI than that in the highest quartile (fourth quartile) of PI. PI (per 1% decrease) was associated with the development of cardiovascular death (Hazard ratio, 1.39; 95% CI, 1.16 to 1.68). PI could be a novel indicator of cardiovascular death in patients with type 2 diabetes and established CVD.
format	article
author	Hiroshi Okada Muhei Tanaka Takashi Yasuda Yuki Okada Hisahiro Norikae Tetsuya Fujita Takashi Nishi Hirokazu Oyamada Tetsuro Yamane Michiaki Fukui
author_facet	Hiroshi Okada Muhei Tanaka Takashi Yasuda Yuki Okada Hisahiro Norikae Tetsuya Fujita Takashi Nishi Hirokazu Oyamada Tetsuro Yamane Michiaki Fukui
author_sort	Hiroshi Okada
title	Decreased peripheral perfusion measured by perfusion index is a novel indicator for cardiovascular death in patients with type 2 diabetes and established cardiovascular disease
title_short	Decreased peripheral perfusion measured by perfusion index is a novel indicator for cardiovascular death in patients with type 2 diabetes and established cardiovascular disease
title_full	Decreased peripheral perfusion measured by perfusion index is a novel indicator for cardiovascular death in patients with type 2 diabetes and established cardiovascular disease
title_fullStr	Decreased peripheral perfusion measured by perfusion index is a novel indicator for cardiovascular death in patients with type 2 diabetes and established cardiovascular disease
title_full_unstemmed	Decreased peripheral perfusion measured by perfusion index is a novel indicator for cardiovascular death in patients with type 2 diabetes and established cardiovascular disease
title_sort	decreased peripheral perfusion measured by perfusion index is a novel indicator for cardiovascular death in patients with type 2 diabetes and established cardiovascular disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/e5ca39c781b54ec58ac6b629abe0d97e
work_keys_str_mv	AT hiroshiokada decreasedperipheralperfusionmeasuredbyperfusionindexisanovelindicatorforcardiovasculardeathinpatientswithtype2diabetesandestablishedcardiovasculardisease AT muheitanaka decreasedperipheralperfusionmeasuredbyperfusionindexisanovelindicatorforcardiovasculardeathinpatientswithtype2diabetesandestablishedcardiovasculardisease AT takashiyasuda decreasedperipheralperfusionmeasuredbyperfusionindexisanovelindicatorforcardiovasculardeathinpatientswithtype2diabetesandestablishedcardiovasculardisease AT yukiokada decreasedperipheralperfusionmeasuredbyperfusionindexisanovelindicatorforcardiovasculardeathinpatientswithtype2diabetesandestablishedcardiovasculardisease AT hisahironorikae decreasedperipheralperfusionmeasuredbyperfusionindexisanovelindicatorforcardiovasculardeathinpatientswithtype2diabetesandestablishedcardiovasculardisease AT tetsuyafujita decreasedperipheralperfusionmeasuredbyperfusionindexisanovelindicatorforcardiovasculardeathinpatientswithtype2diabetesandestablishedcardiovasculardisease AT takashinishi decreasedperipheralperfusionmeasuredbyperfusionindexisanovelindicatorforcardiovasculardeathinpatientswithtype2diabetesandestablishedcardiovasculardisease AT hirokazuoyamada decreasedperipheralperfusionmeasuredbyperfusionindexisanovelindicatorforcardiovasculardeathinpatientswithtype2diabetesandestablishedcardiovasculardisease AT tetsuroyamane decreasedperipheralperfusionmeasuredbyperfusionindexisanovelindicatorforcardiovasculardeathinpatientswithtype2diabetesandestablishedcardiovasculardisease AT michiakifukui decreasedperipheralperfusionmeasuredbyperfusionindexisanovelindicatorforcardiovasculardeathinpatientswithtype2diabetesandestablishedcardiovasculardisease
_version_	1718387299263184896

Decreased peripheral perfusion measured by perfusion index is a novel indicator for cardiovascular death in patients with type 2 diabetes and established cardiovascular disease

Ejemplares similares