Dual microglia effects on blood brain barrier permeability induced by systemic inflammation

Although it is known that microglia respond to injury and systemic disease in the brain, it is unclear if they modulate blood–brain barrier (BBB) integrity, which is critical for regulating neuroinflammatory responses. Here authors demonstrate that microglia respond to inflammation by migrating towa...

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Autores principales:	Koichiro Haruwaka, Ako Ikegami, Yoshihisa Tachibana, Nobuhiko Ohno, Hiroyuki Konishi, Akari Hashimoto, Mami Matsumoto, Daisuke Kato, Riho Ono, Hiroshi Kiyama, Andrew J. Moorhouse, Junichi Nabekura, Hiroaki Wake
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e5cc6bbdb30641829f5b58b0a8df2eaf
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spelling	oai:doaj.org-article:e5cc6bbdb30641829f5b58b0a8df2eaf2021-12-02T15:35:55ZDual microglia effects on blood brain barrier permeability induced by systemic inflammation10.1038/s41467-019-13812-z2041-1723https://doaj.org/article/e5cc6bbdb30641829f5b58b0a8df2eaf2019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13812-zhttps://doaj.org/toc/2041-1723Although it is known that microglia respond to injury and systemic disease in the brain, it is unclear if they modulate blood–brain barrier (BBB) integrity, which is critical for regulating neuroinflammatory responses. Here authors demonstrate that microglia respond to inflammation by migrating towards and accumulating around cerebral vessels, where they initially maintain BBB integrity via expression of the tight-junction protein Claudin-5 before switching, during sustained inflammation, to phagocytically remove astrocytic end-feet resulting in impaired BBB functionKoichiro HaruwakaAko IkegamiYoshihisa TachibanaNobuhiko OhnoHiroyuki KonishiAkari HashimotoMami MatsumotoDaisuke KatoRiho OnoHiroshi KiyamaAndrew J. MoorhouseJunichi NabekuraHiroaki WakeNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Koichiro Haruwaka Ako Ikegami Yoshihisa Tachibana Nobuhiko Ohno Hiroyuki Konishi Akari Hashimoto Mami Matsumoto Daisuke Kato Riho Ono Hiroshi Kiyama Andrew J. Moorhouse Junichi Nabekura Hiroaki Wake Dual microglia effects on blood brain barrier permeability induced by systemic inflammation
description	Although it is known that microglia respond to injury and systemic disease in the brain, it is unclear if they modulate blood–brain barrier (BBB) integrity, which is critical for regulating neuroinflammatory responses. Here authors demonstrate that microglia respond to inflammation by migrating towards and accumulating around cerebral vessels, where they initially maintain BBB integrity via expression of the tight-junction protein Claudin-5 before switching, during sustained inflammation, to phagocytically remove astrocytic end-feet resulting in impaired BBB function
format	article
author	Koichiro Haruwaka Ako Ikegami Yoshihisa Tachibana Nobuhiko Ohno Hiroyuki Konishi Akari Hashimoto Mami Matsumoto Daisuke Kato Riho Ono Hiroshi Kiyama Andrew J. Moorhouse Junichi Nabekura Hiroaki Wake
author_facet	Koichiro Haruwaka Ako Ikegami Yoshihisa Tachibana Nobuhiko Ohno Hiroyuki Konishi Akari Hashimoto Mami Matsumoto Daisuke Kato Riho Ono Hiroshi Kiyama Andrew J. Moorhouse Junichi Nabekura Hiroaki Wake
author_sort	Koichiro Haruwaka
title	Dual microglia effects on blood brain barrier permeability induced by systemic inflammation
title_short	Dual microglia effects on blood brain barrier permeability induced by systemic inflammation
title_full	Dual microglia effects on blood brain barrier permeability induced by systemic inflammation
title_fullStr	Dual microglia effects on blood brain barrier permeability induced by systemic inflammation
title_full_unstemmed	Dual microglia effects on blood brain barrier permeability induced by systemic inflammation
title_sort	dual microglia effects on blood brain barrier permeability induced by systemic inflammation
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/e5cc6bbdb30641829f5b58b0a8df2eaf
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Dual microglia effects on blood brain barrier permeability induced by systemic inflammation

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