Chronic alcohol exposure disrupts top-down control over basal ganglia action selection to produce habits

Drug dependence shifts the balance in action selection away from goal-directed to habitual responding. Here, the authors report that chronic passive exposure to alcohol leads to suppression of orbitofrontal cortex inputs to dorsomedial striatum resulting in downregulation of goal-directed behavior.

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Autores principales:	Rafael Renteria, Emily T. Baltz, Christina M. Gremel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e5cd28663bd242ea9e1ab8a47e9caa49
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spelling	oai:doaj.org-article:e5cd28663bd242ea9e1ab8a47e9caa492021-12-02T17:33:04ZChronic alcohol exposure disrupts top-down control over basal ganglia action selection to produce habits10.1038/s41467-017-02615-92041-1723https://doaj.org/article/e5cd28663bd242ea9e1ab8a47e9caa492018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02615-9https://doaj.org/toc/2041-1723Drug dependence shifts the balance in action selection away from goal-directed to habitual responding. Here, the authors report that chronic passive exposure to alcohol leads to suppression of orbitofrontal cortex inputs to dorsomedial striatum resulting in downregulation of goal-directed behavior.Rafael RenteriaEmily T. BaltzChristina M. GremelNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rafael Renteria Emily T. Baltz Christina M. Gremel Chronic alcohol exposure disrupts top-down control over basal ganglia action selection to produce habits
description	Drug dependence shifts the balance in action selection away from goal-directed to habitual responding. Here, the authors report that chronic passive exposure to alcohol leads to suppression of orbitofrontal cortex inputs to dorsomedial striatum resulting in downregulation of goal-directed behavior.
format	article
author	Rafael Renteria Emily T. Baltz Christina M. Gremel
author_facet	Rafael Renteria Emily T. Baltz Christina M. Gremel
author_sort	Rafael Renteria
title	Chronic alcohol exposure disrupts top-down control over basal ganglia action selection to produce habits
title_short	Chronic alcohol exposure disrupts top-down control over basal ganglia action selection to produce habits
title_full	Chronic alcohol exposure disrupts top-down control over basal ganglia action selection to produce habits
title_fullStr	Chronic alcohol exposure disrupts top-down control over basal ganglia action selection to produce habits
title_full_unstemmed	Chronic alcohol exposure disrupts top-down control over basal ganglia action selection to produce habits
title_sort	chronic alcohol exposure disrupts top-down control over basal ganglia action selection to produce habits
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/e5cd28663bd242ea9e1ab8a47e9caa49
work_keys_str_mv	AT rafaelrenteria chronicalcoholexposuredisruptstopdowncontroloverbasalgangliaactionselectiontoproducehabits AT emilytbaltz chronicalcoholexposuredisruptstopdowncontroloverbasalgangliaactionselectiontoproducehabits AT christinamgremel chronicalcoholexposuredisruptstopdowncontroloverbasalgangliaactionselectiontoproducehabits
_version_	1718380094976688128

Chronic alcohol exposure disrupts top-down control over basal ganglia action selection to produce habits

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