FMRP regulates an ethanol-dependent shift in GABABR function and expression with rapid antidepressant properties

Alcohol is thought to lead to neuroadaptive changes, although the underlying molecular mechanisms are unclear. Here, the authors find ethanol treatment alters GABAB-receptor expression via fragile-X mental retardation protein in mice, leading to antidepressant-like behaviours.

Guardado en:

Detalles Bibliográficos
Autores principales:	Sarah A. Wolfe, Emily R. Workman, Chelcie F. Heaney, Farr Niere, Sanjeev Namjoshi, Luisa P. Cacheaux, Sean P. Farris, Michael R. Drew, Boris V. Zemelman, R. Adron Harris, Kimberly F. Raab-Graham
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e5cec5c74cef40f9abc05988792bd8e3
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e5cec5c74cef40f9abc05988792bd8e3
record_format	dspace
spelling	oai:doaj.org-article:e5cec5c74cef40f9abc05988792bd8e32021-12-02T14:40:16ZFMRP regulates an ethanol-dependent shift in GABABR function and expression with rapid antidepressant properties10.1038/ncomms128672041-1723https://doaj.org/article/e5cec5c74cef40f9abc05988792bd8e32016-09-01T00:00:00Zhttps://doi.org/10.1038/ncomms12867https://doaj.org/toc/2041-1723Alcohol is thought to lead to neuroadaptive changes, although the underlying molecular mechanisms are unclear. Here, the authors find ethanol treatment alters GABAB-receptor expression via fragile-X mental retardation protein in mice, leading to antidepressant-like behaviours.Sarah A. WolfeEmily R. WorkmanChelcie F. HeaneyFarr NiereSanjeev NamjoshiLuisa P. CacheauxSean P. FarrisMichael R. DrewBoris V. ZemelmanR. Adron HarrisKimberly F. Raab-GrahamNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sarah A. Wolfe Emily R. Workman Chelcie F. Heaney Farr Niere Sanjeev Namjoshi Luisa P. Cacheaux Sean P. Farris Michael R. Drew Boris V. Zemelman R. Adron Harris Kimberly F. Raab-Graham FMRP regulates an ethanol-dependent shift in GABABR function and expression with rapid antidepressant properties
description	Alcohol is thought to lead to neuroadaptive changes, although the underlying molecular mechanisms are unclear. Here, the authors find ethanol treatment alters GABAB-receptor expression via fragile-X mental retardation protein in mice, leading to antidepressant-like behaviours.
format	article
author	Sarah A. Wolfe Emily R. Workman Chelcie F. Heaney Farr Niere Sanjeev Namjoshi Luisa P. Cacheaux Sean P. Farris Michael R. Drew Boris V. Zemelman R. Adron Harris Kimberly F. Raab-Graham
author_facet	Sarah A. Wolfe Emily R. Workman Chelcie F. Heaney Farr Niere Sanjeev Namjoshi Luisa P. Cacheaux Sean P. Farris Michael R. Drew Boris V. Zemelman R. Adron Harris Kimberly F. Raab-Graham
author_sort	Sarah A. Wolfe
title	FMRP regulates an ethanol-dependent shift in GABABR function and expression with rapid antidepressant properties
title_short	FMRP regulates an ethanol-dependent shift in GABABR function and expression with rapid antidepressant properties
title_full	FMRP regulates an ethanol-dependent shift in GABABR function and expression with rapid antidepressant properties
title_fullStr	FMRP regulates an ethanol-dependent shift in GABABR function and expression with rapid antidepressant properties
title_full_unstemmed	FMRP regulates an ethanol-dependent shift in GABABR function and expression with rapid antidepressant properties
title_sort	fmrp regulates an ethanol-dependent shift in gababr function and expression with rapid antidepressant properties
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/e5cec5c74cef40f9abc05988792bd8e3
work_keys_str_mv	AT sarahawolfe fmrpregulatesanethanoldependentshiftingababrfunctionandexpressionwithrapidantidepressantproperties AT emilyrworkman fmrpregulatesanethanoldependentshiftingababrfunctionandexpressionwithrapidantidepressantproperties AT chelciefheaney fmrpregulatesanethanoldependentshiftingababrfunctionandexpressionwithrapidantidepressantproperties AT farrniere fmrpregulatesanethanoldependentshiftingababrfunctionandexpressionwithrapidantidepressantproperties AT sanjeevnamjoshi fmrpregulatesanethanoldependentshiftingababrfunctionandexpressionwithrapidantidepressantproperties AT luisapcacheaux fmrpregulatesanethanoldependentshiftingababrfunctionandexpressionwithrapidantidepressantproperties AT seanpfarris fmrpregulatesanethanoldependentshiftingababrfunctionandexpressionwithrapidantidepressantproperties AT michaelrdrew fmrpregulatesanethanoldependentshiftingababrfunctionandexpressionwithrapidantidepressantproperties AT borisvzemelman fmrpregulatesanethanoldependentshiftingababrfunctionandexpressionwithrapidantidepressantproperties AT radronharris fmrpregulatesanethanoldependentshiftingababrfunctionandexpressionwithrapidantidepressantproperties AT kimberlyfraabgraham fmrpregulatesanethanoldependentshiftingababrfunctionandexpressionwithrapidantidepressantproperties
_version_	1718390391836770304

FMRP regulates an ethanol-dependent shift in GABABR function and expression with rapid antidepressant properties

Ejemplares similares