Drug repurposing for tooth regeneration: The promising premises

Drug repurposing which identifies new therapeutic use(s) for drugs currently in use is a brand-new avenue of research interest worldwide. It circumvents the high-end monetary and time investment usually associated with contemporary drug discoveries. In the field of dentistry, recent studies in drug...

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Autores principales:	T C Divya, Sapna Chandira Muddappa, Prabath Singh, Rakesh R Rajan, M Remya, Deepthy Sreehari
Formato:	article
Lenguaje:	EN
Publicado:	Wolters Kluwer Medknow Publications 2021
Materias:	aspirin dentine regeneration drug repurposing metformin tideglusib Pharmacy and materia medica RS1-441 Analytical chemistry QD71-142
Acceso en línea:	https://doaj.org/article/e5d486d7a14143ed982f62e28de69b5a
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spelling	oai:doaj.org-article:e5d486d7a14143ed982f62e28de69b5a2021-11-19T12:15:51ZDrug repurposing for tooth regeneration: The promising premises0975-740610.4103/jpbs.jpbs_67_21https://doaj.org/article/e5d486d7a14143ed982f62e28de69b5a2021-01-01T00:00:00Zhttp://www.jpbsonline.org/article.asp?issn=0975-7406;year=2021;volume=13;issue=6;spage=957;epage=959;aulast=Divyahttps://doaj.org/toc/0975-7406Drug repurposing which identifies new therapeutic use(s) for drugs currently in use is a brand-new avenue of research interest worldwide. It circumvents the high-end monetary and time investment usually associated with contemporary drug discoveries. In the field of dentistry, recent studies in drug repurposing focuses in attaining dentin repair or reduction of bone resorption associated with apical periodontitis. Metformin, an anti-diabetic drug has shown pro-osteogenic properties. Aspirin a known anti-inflammatory agent with anticoagulant action is found to modulate the differentiation of dental pulp cells. The significant role of glycogen synthase kinase-3 inhibitors in activating the Wnt/-beta cat signaling pathway of mesenchymal pulp stem cells may pave the way to the pharmacological treatment of dental caries in near future. It is to be noted here that further preclinical and clinical studies are warranted for the regular therapeutic use of these potential drugs in clinical dentistry.T C DivyaSapna Chandira MuddappaPrabath SinghRakesh R RajanM RemyaDeepthy SreehariWolters Kluwer Medknow Publicationsarticleaspirindentine regenerationdrug repurposingmetformintideglusibPharmacy and materia medicaRS1-441Analytical chemistryQD71-142ENJournal of Pharmacy and Bioallied Sciences, Vol 13, Iss 6, Pp 957-959 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	aspirin dentine regeneration drug repurposing metformin tideglusib Pharmacy and materia medica RS1-441 Analytical chemistry QD71-142
spellingShingle	aspirin dentine regeneration drug repurposing metformin tideglusib Pharmacy and materia medica RS1-441 Analytical chemistry QD71-142 T C Divya Sapna Chandira Muddappa Prabath Singh Rakesh R Rajan M Remya Deepthy Sreehari Drug repurposing for tooth regeneration: The promising premises
description	Drug repurposing which identifies new therapeutic use(s) for drugs currently in use is a brand-new avenue of research interest worldwide. It circumvents the high-end monetary and time investment usually associated with contemporary drug discoveries. In the field of dentistry, recent studies in drug repurposing focuses in attaining dentin repair or reduction of bone resorption associated with apical periodontitis. Metformin, an anti-diabetic drug has shown pro-osteogenic properties. Aspirin a known anti-inflammatory agent with anticoagulant action is found to modulate the differentiation of dental pulp cells. The significant role of glycogen synthase kinase-3 inhibitors in activating the Wnt/-beta cat signaling pathway of mesenchymal pulp stem cells may pave the way to the pharmacological treatment of dental caries in near future. It is to be noted here that further preclinical and clinical studies are warranted for the regular therapeutic use of these potential drugs in clinical dentistry.
format	article
author	T C Divya Sapna Chandira Muddappa Prabath Singh Rakesh R Rajan M Remya Deepthy Sreehari
author_facet	T C Divya Sapna Chandira Muddappa Prabath Singh Rakesh R Rajan M Remya Deepthy Sreehari
author_sort	T C Divya
title	Drug repurposing for tooth regeneration: The promising premises
title_short	Drug repurposing for tooth regeneration: The promising premises
title_full	Drug repurposing for tooth regeneration: The promising premises
title_fullStr	Drug repurposing for tooth regeneration: The promising premises
title_full_unstemmed	Drug repurposing for tooth regeneration: The promising premises
title_sort	drug repurposing for tooth regeneration: the promising premises
publisher	Wolters Kluwer Medknow Publications
publishDate	2021
url	https://doaj.org/article/e5d486d7a14143ed982f62e28de69b5a
work_keys_str_mv	AT tcdivya drugrepurposingfortoothregenerationthepromisingpremises AT sapnachandiramuddappa drugrepurposingfortoothregenerationthepromisingpremises AT prabathsingh drugrepurposingfortoothregenerationthepromisingpremises AT rakeshrrajan drugrepurposingfortoothregenerationthepromisingpremises AT mremya drugrepurposingfortoothregenerationthepromisingpremises AT deepthysreehari drugrepurposingfortoothregenerationthepromisingpremises
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Drug repurposing for tooth regeneration: The promising premises

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