Heart regeneration in the salamander relies on macrophage-mediated control of fibroblast activation and the extracellular landscape

Macrophages necessary for heart regeneration Heart regeneration in salamanders is dependent on the activation of immune cells. James Godwin of The Jackson Laboratory and MDI Biological Laboratory in the US and colleagues depleted all major organs of a group of Mexican salamanders of macrophages, an...

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Autores principales:	J. W. Godwin, R. Debuque, E. Salimova, N. A. Rosenthal
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R
Acceso en línea:	https://doaj.org/article/e5d673fd7ab54650809f36a3dd833ccc
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spelling	oai:doaj.org-article:e5d673fd7ab54650809f36a3dd833ccc2021-12-02T13:41:45ZHeart regeneration in the salamander relies on macrophage-mediated control of fibroblast activation and the extracellular landscape10.1038/s41536-017-0027-y2057-3995https://doaj.org/article/e5d673fd7ab54650809f36a3dd833ccc2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41536-017-0027-yhttps://doaj.org/toc/2057-3995Macrophages necessary for heart regeneration Heart regeneration in salamanders is dependent on the activation of immune cells. James Godwin of The Jackson Laboratory and MDI Biological Laboratory in the US and colleagues depleted all major organs of a group of Mexican salamanders of macrophages, an immune cell responsible for removing cellular debris. They then injured the salamanders’ heart wall with a liquid nitrogen-cooled probe. Unlike adult mammals, zebrafish and salamanders can normally regenerate their hearts after injury. The team found that macrophage-depleted salamanders were unable to regenerate their hearts compared to a control group. Macrophage depletion led to the formation of a permanent fibrotic extracellular matrix scar. But it did not affect the proliferation of heart muscle cells, indicating that their function is not sufficient to prevent the progression of injury toward fibrosis instead of regeneration.J. W. GodwinR. DebuqueE. SalimovaN. A. RosenthalNature PortfolioarticleMedicineRENnpj Regenerative Medicine, Vol 2, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R
spellingShingle	Medicine R J. W. Godwin R. Debuque E. Salimova N. A. Rosenthal Heart regeneration in the salamander relies on macrophage-mediated control of fibroblast activation and the extracellular landscape
description	Macrophages necessary for heart regeneration Heart regeneration in salamanders is dependent on the activation of immune cells. James Godwin of The Jackson Laboratory and MDI Biological Laboratory in the US and colleagues depleted all major organs of a group of Mexican salamanders of macrophages, an immune cell responsible for removing cellular debris. They then injured the salamanders’ heart wall with a liquid nitrogen-cooled probe. Unlike adult mammals, zebrafish and salamanders can normally regenerate their hearts after injury. The team found that macrophage-depleted salamanders were unable to regenerate their hearts compared to a control group. Macrophage depletion led to the formation of a permanent fibrotic extracellular matrix scar. But it did not affect the proliferation of heart muscle cells, indicating that their function is not sufficient to prevent the progression of injury toward fibrosis instead of regeneration.
format	article
author	J. W. Godwin R. Debuque E. Salimova N. A. Rosenthal
author_facet	J. W. Godwin R. Debuque E. Salimova N. A. Rosenthal
author_sort	J. W. Godwin
title	Heart regeneration in the salamander relies on macrophage-mediated control of fibroblast activation and the extracellular landscape
title_short	Heart regeneration in the salamander relies on macrophage-mediated control of fibroblast activation and the extracellular landscape
title_full	Heart regeneration in the salamander relies on macrophage-mediated control of fibroblast activation and the extracellular landscape
title_fullStr	Heart regeneration in the salamander relies on macrophage-mediated control of fibroblast activation and the extracellular landscape
title_full_unstemmed	Heart regeneration in the salamander relies on macrophage-mediated control of fibroblast activation and the extracellular landscape
title_sort	heart regeneration in the salamander relies on macrophage-mediated control of fibroblast activation and the extracellular landscape
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/e5d673fd7ab54650809f36a3dd833ccc
work_keys_str_mv	AT jwgodwin heartregenerationinthesalamanderreliesonmacrophagemediatedcontroloffibroblastactivationandtheextracellularlandscape AT rdebuque heartregenerationinthesalamanderreliesonmacrophagemediatedcontroloffibroblastactivationandtheextracellularlandscape AT esalimova heartregenerationinthesalamanderreliesonmacrophagemediatedcontroloffibroblastactivationandtheextracellularlandscape AT narosenthal heartregenerationinthesalamanderreliesonmacrophagemediatedcontroloffibroblastactivationandtheextracellularlandscape
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Heart regeneration in the salamander relies on macrophage-mediated control of fibroblast activation and the extracellular landscape

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