Adrenomedullin-CALCRL axis controls relapse-initiating drug tolerant acute myeloid leukemia cells
Leukemic stem cells which are resistant to chemotherapy are proposed as relapse-initiating cells (RICs). Here, the authors show that targeting the adrenomedullin-calcitonin receptor-like receptor decreases RICs frequency improving chemotherapy response in AML preclinical models.
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Nature Portfolio
2021
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oai:doaj.org-article:e5db0cc7b23d4c7f80b655c467b009212021-12-02T13:48:51ZAdrenomedullin-CALCRL axis controls relapse-initiating drug tolerant acute myeloid leukemia cells10.1038/s41467-020-20717-92041-1723https://doaj.org/article/e5db0cc7b23d4c7f80b655c467b009212021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20717-9https://doaj.org/toc/2041-1723Leukemic stem cells which are resistant to chemotherapy are proposed as relapse-initiating cells (RICs). Here, the authors show that targeting the adrenomedullin-calcitonin receptor-like receptor decreases RICs frequency improving chemotherapy response in AML preclinical models.Clément LarrueNathan GuiraudPierre-Luc MouchelMarine DuboisThomas FargeMathilde GotanègreClaudie BoscEstelle SalandMarie-Laure Nicolau-TraversMarie SabatierNizar SerhanAmbrine SahalEmeline BoetSarah MoucheQuentin HeydtNesrine ArouaLucille StuaniTony KaomaLinus AngenendtJan-Henrik MikeschChristoph SchliemannFrançois VergezJérôme TamburiniChristian RécherJean-Emmanuel SarryNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021) |
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DOAJ |
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DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Clément Larrue Nathan Guiraud Pierre-Luc Mouchel Marine Dubois Thomas Farge Mathilde Gotanègre Claudie Bosc Estelle Saland Marie-Laure Nicolau-Travers Marie Sabatier Nizar Serhan Ambrine Sahal Emeline Boet Sarah Mouche Quentin Heydt Nesrine Aroua Lucille Stuani Tony Kaoma Linus Angenendt Jan-Henrik Mikesch Christoph Schliemann François Vergez Jérôme Tamburini Christian Récher Jean-Emmanuel Sarry Adrenomedullin-CALCRL axis controls relapse-initiating drug tolerant acute myeloid leukemia cells |
| description |
Leukemic stem cells which are resistant to chemotherapy are proposed as relapse-initiating cells (RICs). Here, the authors show that targeting the adrenomedullin-calcitonin receptor-like receptor decreases RICs frequency improving chemotherapy response in AML preclinical models. |
| format |
article |
| author |
Clément Larrue Nathan Guiraud Pierre-Luc Mouchel Marine Dubois Thomas Farge Mathilde Gotanègre Claudie Bosc Estelle Saland Marie-Laure Nicolau-Travers Marie Sabatier Nizar Serhan Ambrine Sahal Emeline Boet Sarah Mouche Quentin Heydt Nesrine Aroua Lucille Stuani Tony Kaoma Linus Angenendt Jan-Henrik Mikesch Christoph Schliemann François Vergez Jérôme Tamburini Christian Récher Jean-Emmanuel Sarry |
| author_facet |
Clément Larrue Nathan Guiraud Pierre-Luc Mouchel Marine Dubois Thomas Farge Mathilde Gotanègre Claudie Bosc Estelle Saland Marie-Laure Nicolau-Travers Marie Sabatier Nizar Serhan Ambrine Sahal Emeline Boet Sarah Mouche Quentin Heydt Nesrine Aroua Lucille Stuani Tony Kaoma Linus Angenendt Jan-Henrik Mikesch Christoph Schliemann François Vergez Jérôme Tamburini Christian Récher Jean-Emmanuel Sarry |
| author_sort |
Clément Larrue |
| title |
Adrenomedullin-CALCRL axis controls relapse-initiating drug tolerant acute myeloid leukemia cells |
| title_short |
Adrenomedullin-CALCRL axis controls relapse-initiating drug tolerant acute myeloid leukemia cells |
| title_full |
Adrenomedullin-CALCRL axis controls relapse-initiating drug tolerant acute myeloid leukemia cells |
| title_fullStr |
Adrenomedullin-CALCRL axis controls relapse-initiating drug tolerant acute myeloid leukemia cells |
| title_full_unstemmed |
Adrenomedullin-CALCRL axis controls relapse-initiating drug tolerant acute myeloid leukemia cells |
| title_sort |
adrenomedullin-calcrl axis controls relapse-initiating drug tolerant acute myeloid leukemia cells |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/e5db0cc7b23d4c7f80b655c467b00921 |
| work_keys_str_mv |
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