Histone variant H2A.B-H2B dimers are spontaneously exchanged with canonical H2A-H2B in the nucleosome

Hirano et al. show that the H2A.B-H2B histone dimer incorporated within the nucleosome exchanges with the canonical H2A-H2B dimer without assistance from histone chaperones or nucleosome remodelers. This study provides insights into how the H2A.B nucleosome exchanges its histones.

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Detalles Bibliográficos
Autores principales: Rina Hirano, Yasuhiro Arimura, Tomoya Kujirai, Mikihiro Shibata, Aya Okuda, Ken Morishima, Rintaro Inoue, Masaaki Sugiyama, Hitoshi Kurumizaka
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/e5db19da91414c99b864481c4f745c6e
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Sumario:Hirano et al. show that the H2A.B-H2B histone dimer incorporated within the nucleosome exchanges with the canonical H2A-H2B dimer without assistance from histone chaperones or nucleosome remodelers. This study provides insights into how the H2A.B nucleosome exchanges its histones.