Longitudinal monitoring of laboratory markers characterizes hospitalized and ambulatory COVID-19 patients

Longitudinal monitoring of laboratory markers characterizes hospitalized and ambulatory COVID-19 patients

Abstract Early detection of severe forms of COVID-19 is absolutely essential for timely triage of patients. We longitudinally followed-up two well-characterized patient groups, hospitalized moderate to severe (n = 26), and ambulatory mild COVID-19 patients (n = 16) at home quarantine. Human D-dimer,...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Thirumalaisamy P. Velavan, Salih Kuk, Le Thi Kieu Linh, Carlos Lamsfus Calle, Albert Lalremruata, Srinivas Reddy Pallerla, Andrea Kreidenweiss, Jana Held, Meral Esen, Julian Gabor, Eva Maria Neurohr, Parichehr Shamsrizi, Anahita Fathi, Erwin Biecker, Christoph P. Berg, Michael Ramharter, Marylyn Martina Addo, Benno Kreuels, Peter G. Kremsner
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/e5dce0aa5f814813812fa7a033bb0c68
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
Descripción
Sumario:Abstract Early detection of severe forms of COVID-19 is absolutely essential for timely triage of patients. We longitudinally followed-up two well-characterized patient groups, hospitalized moderate to severe (n = 26), and ambulatory mild COVID-19 patients (n = 16) at home quarantine. Human D-dimer, C-reactive protein (CRP), ferritin, cardiac troponin I, interleukin-6 (IL-6) levels were measured on day 1, day 7, day 14 and day 28. All hospitalized patients were SARS-CoV-2 positive on admission, while all ambulatory patients were SARS-CoV-2 positive at recruitment. Hospitalized patients had higher D-dimer, CRP and ferritin, cardiac troponin I and IL-6 levels than ambulatory patients (p < 0.001, p < 0.001, p = 0.016, p = 0.035, p = 0.002 respectively). Hospitalized patients experienced significant decreases in CRP, ferritin and IL-6 levels from admission to recovery (p < 0.001, p = 0.025, and p = 0.001 respectively). Cardiac troponin I levels were high during the acute phase in both hospitalized and ambulatory patients, indicating a potential myocardial injury. In summary, D-dimer, CRP, ferritin, cardiac troponin I, IL-6 are predictive laboratory markers and can largely determine the clinical course of COVID-19, in particular the prognosis of critically ill COVID-19 patients.

Ejemplares similares