Longitudinal monitoring of laboratory markers characterizes hospitalized and ambulatory COVID-19 patients
Abstract Early detection of severe forms of COVID-19 is absolutely essential for timely triage of patients. We longitudinally followed-up two well-characterized patient groups, hospitalized moderate to severe (n = 26), and ambulatory mild COVID-19 patients (n = 16) at home quarantine. Human D-dimer,...
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Nature Portfolio
2021
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oai:doaj.org-article:e5dce0aa5f814813812fa7a033bb0c682021-12-02T16:08:07ZLongitudinal monitoring of laboratory markers characterizes hospitalized and ambulatory COVID-19 patients10.1038/s41598-021-93950-x2045-2322https://doaj.org/article/e5dce0aa5f814813812fa7a033bb0c682021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93950-xhttps://doaj.org/toc/2045-2322Abstract Early detection of severe forms of COVID-19 is absolutely essential for timely triage of patients. We longitudinally followed-up two well-characterized patient groups, hospitalized moderate to severe (n = 26), and ambulatory mild COVID-19 patients (n = 16) at home quarantine. Human D-dimer, C-reactive protein (CRP), ferritin, cardiac troponin I, interleukin-6 (IL-6) levels were measured on day 1, day 7, day 14 and day 28. All hospitalized patients were SARS-CoV-2 positive on admission, while all ambulatory patients were SARS-CoV-2 positive at recruitment. Hospitalized patients had higher D-dimer, CRP and ferritin, cardiac troponin I and IL-6 levels than ambulatory patients (p < 0.001, p < 0.001, p = 0.016, p = 0.035, p = 0.002 respectively). Hospitalized patients experienced significant decreases in CRP, ferritin and IL-6 levels from admission to recovery (p < 0.001, p = 0.025, and p = 0.001 respectively). Cardiac troponin I levels were high during the acute phase in both hospitalized and ambulatory patients, indicating a potential myocardial injury. In summary, D-dimer, CRP, ferritin, cardiac troponin I, IL-6 are predictive laboratory markers and can largely determine the clinical course of COVID-19, in particular the prognosis of critically ill COVID-19 patients.Thirumalaisamy P. VelavanSalih KukLe Thi Kieu LinhCarlos Lamsfus CalleAlbert LalremruataSrinivas Reddy PallerlaAndrea KreidenweissJana HeldMeral EsenJulian GaborEva Maria NeurohrParichehr ShamsriziAnahita FathiErwin BieckerChristoph P. BergMichael RamharterMarylyn Martina AddoBenno KreuelsPeter G. KremsnerNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021) |
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DOAJ |
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Medicine R Science Q Thirumalaisamy P. Velavan Salih Kuk Le Thi Kieu Linh Carlos Lamsfus Calle Albert Lalremruata Srinivas Reddy Pallerla Andrea Kreidenweiss Jana Held Meral Esen Julian Gabor Eva Maria Neurohr Parichehr Shamsrizi Anahita Fathi Erwin Biecker Christoph P. Berg Michael Ramharter Marylyn Martina Addo Benno Kreuels Peter G. Kremsner Longitudinal monitoring of laboratory markers characterizes hospitalized and ambulatory COVID-19 patients |
| description |
Abstract Early detection of severe forms of COVID-19 is absolutely essential for timely triage of patients. We longitudinally followed-up two well-characterized patient groups, hospitalized moderate to severe (n = 26), and ambulatory mild COVID-19 patients (n = 16) at home quarantine. Human D-dimer, C-reactive protein (CRP), ferritin, cardiac troponin I, interleukin-6 (IL-6) levels were measured on day 1, day 7, day 14 and day 28. All hospitalized patients were SARS-CoV-2 positive on admission, while all ambulatory patients were SARS-CoV-2 positive at recruitment. Hospitalized patients had higher D-dimer, CRP and ferritin, cardiac troponin I and IL-6 levels than ambulatory patients (p < 0.001, p < 0.001, p = 0.016, p = 0.035, p = 0.002 respectively). Hospitalized patients experienced significant decreases in CRP, ferritin and IL-6 levels from admission to recovery (p < 0.001, p = 0.025, and p = 0.001 respectively). Cardiac troponin I levels were high during the acute phase in both hospitalized and ambulatory patients, indicating a potential myocardial injury. In summary, D-dimer, CRP, ferritin, cardiac troponin I, IL-6 are predictive laboratory markers and can largely determine the clinical course of COVID-19, in particular the prognosis of critically ill COVID-19 patients. |
| format |
article |
| author |
Thirumalaisamy P. Velavan Salih Kuk Le Thi Kieu Linh Carlos Lamsfus Calle Albert Lalremruata Srinivas Reddy Pallerla Andrea Kreidenweiss Jana Held Meral Esen Julian Gabor Eva Maria Neurohr Parichehr Shamsrizi Anahita Fathi Erwin Biecker Christoph P. Berg Michael Ramharter Marylyn Martina Addo Benno Kreuels Peter G. Kremsner |
| author_facet |
Thirumalaisamy P. Velavan Salih Kuk Le Thi Kieu Linh Carlos Lamsfus Calle Albert Lalremruata Srinivas Reddy Pallerla Andrea Kreidenweiss Jana Held Meral Esen Julian Gabor Eva Maria Neurohr Parichehr Shamsrizi Anahita Fathi Erwin Biecker Christoph P. Berg Michael Ramharter Marylyn Martina Addo Benno Kreuels Peter G. Kremsner |
| author_sort |
Thirumalaisamy P. Velavan |
| title |
Longitudinal monitoring of laboratory markers characterizes hospitalized and ambulatory COVID-19 patients |
| title_short |
Longitudinal monitoring of laboratory markers characterizes hospitalized and ambulatory COVID-19 patients |
| title_full |
Longitudinal monitoring of laboratory markers characterizes hospitalized and ambulatory COVID-19 patients |
| title_fullStr |
Longitudinal monitoring of laboratory markers characterizes hospitalized and ambulatory COVID-19 patients |
| title_full_unstemmed |
Longitudinal monitoring of laboratory markers characterizes hospitalized and ambulatory COVID-19 patients |
| title_sort |
longitudinal monitoring of laboratory markers characterizes hospitalized and ambulatory covid-19 patients |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/e5dce0aa5f814813812fa7a033bb0c68 |
| work_keys_str_mv |
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