The association between vincristine‐induced peripheral neuropathy and health‐related quality of life in children with cancer

Abstract Purpose Vincristine (VCR) is a chemotherapeutic agent used in the treatment of pediatric oncology patients, but its main toxicity is VCR‐induced peripheral neuropathy (VIPN). However, whether VIPN has an effect on health‐related quality of life (HR‐QoL) in children during treatment is unkno...

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Autores principales:	Mirjam E. van deVelde, Marleen. H. van denBerg, Gertjan J. L. Kaspers, Floor C. H. Abbink, Jos W. R. Twisk, Inge M. van derSluis, Cor van denBos, Marry M. van denHeuvel‐Eibrink, Heidi Segers, Christophe Chantrain, Jutte van derWerff Ten Bosch, Leen Willems, Raphaële R. L. vanLitsenburg
Formato:	article
Lenguaje:	EN
Publicado:	Wiley 2021
Materias:	cancer children neurotoxicity PedsQL Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/e5e35beb568340dda7f7b38abc4d5585
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spelling	oai:doaj.org-article:e5e35beb568340dda7f7b38abc4d55852021-11-22T09:08:48ZThe association between vincristine‐induced peripheral neuropathy and health‐related quality of life in children with cancer2045-763410.1002/cam4.4289https://doaj.org/article/e5e35beb568340dda7f7b38abc4d55852021-11-01T00:00:00Zhttps://doi.org/10.1002/cam4.4289https://doaj.org/toc/2045-7634Abstract Purpose Vincristine (VCR) is a chemotherapeutic agent used in the treatment of pediatric oncology patients, but its main toxicity is VCR‐induced peripheral neuropathy (VIPN). However, whether VIPN has an effect on health‐related quality of life (HR‐QoL) in children during treatment is unknown. Therefore, the aim of our study was to investigate the association between VIPN and HR‐QoL in children starting treatment for cancer. Methods Measurements of VIPN were performed using two tools: Common Terminology Criteria for Adverse Events (CTCAE) and pediatric‐modified Total Neuropathy Score (ped‐mTNS). Assessment of HR‐QoL was done with self‐ and proxy assessment of the Cancer and Generic module of the Pediatric Cancer Quality of Life Inventory™ (PedsQL). Results In total, N = 86 children were included. HR‐QoL of children with VIPN (n = 67%, 76%) was significantly lower in comparison with children without VIPN: estimated Total score of PedsQL Generic (proxy) 84.57; β = −8.96 and 95% confidence interval (CI) −14.48 to −3.43; p = 0.002, estimated PedsQL Generic Total score (self‐reported): 85.16, β = −8.38 (95% CI: −13.76 to −3.00); p = 0.003. Similar results were found in the Pain and Hurt domain of the PedsQL Cancer (pain: estimated score [proxy]: 85.28, β = −9.94 [95%CI: −16.44 to −3.45], p = 0.003; hurt: estimated score [self‐report] 97.57, β = −19.15 [95%CI: −26.82 to −11.48], p < 0.001). Conclusion VIPN results in a significant reduction of HR‐QoL in children under treatment for a malignancy, which means that VIPN is important for the well‐being of pediatric oncology patients. Therefore, this study underlines the importance of optimizing treatment with VCR, thereby aiming to reduce VIPN while maintaining efficacy.Mirjam E. van deVeldeMarleen. H. van denBergGertjan J. L. KaspersFloor C. H. AbbinkJos W. R. TwiskInge M. van derSluisCor van denBosMarry M. van denHeuvel‐EibrinkHeidi SegersChristophe ChantrainJutte van derWerff Ten BoschLeen WillemsRaphaële R. L. vanLitsenburgWileyarticlecancerchildrenneurotoxicityPedsQLNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancer Medicine, Vol 10, Iss 22, Pp 8172-8181 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cancer children neurotoxicity PedsQL Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	cancer children neurotoxicity PedsQL Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Mirjam E. van deVelde Marleen. H. van denBerg Gertjan J. L. Kaspers Floor C. H. Abbink Jos W. R. Twisk Inge M. van derSluis Cor van denBos Marry M. van denHeuvel‐Eibrink Heidi Segers Christophe Chantrain Jutte van derWerff Ten Bosch Leen Willems Raphaële R. L. vanLitsenburg The association between vincristine‐induced peripheral neuropathy and health‐related quality of life in children with cancer
description	Abstract Purpose Vincristine (VCR) is a chemotherapeutic agent used in the treatment of pediatric oncology patients, but its main toxicity is VCR‐induced peripheral neuropathy (VIPN). However, whether VIPN has an effect on health‐related quality of life (HR‐QoL) in children during treatment is unknown. Therefore, the aim of our study was to investigate the association between VIPN and HR‐QoL in children starting treatment for cancer. Methods Measurements of VIPN were performed using two tools: Common Terminology Criteria for Adverse Events (CTCAE) and pediatric‐modified Total Neuropathy Score (ped‐mTNS). Assessment of HR‐QoL was done with self‐ and proxy assessment of the Cancer and Generic module of the Pediatric Cancer Quality of Life Inventory™ (PedsQL). Results In total, N = 86 children were included. HR‐QoL of children with VIPN (n = 67%, 76%) was significantly lower in comparison with children without VIPN: estimated Total score of PedsQL Generic (proxy) 84.57; β = −8.96 and 95% confidence interval (CI) −14.48 to −3.43; p = 0.002, estimated PedsQL Generic Total score (self‐reported): 85.16, β = −8.38 (95% CI: −13.76 to −3.00); p = 0.003. Similar results were found in the Pain and Hurt domain of the PedsQL Cancer (pain: estimated score [proxy]: 85.28, β = −9.94 [95%CI: −16.44 to −3.45], p = 0.003; hurt: estimated score [self‐report] 97.57, β = −19.15 [95%CI: −26.82 to −11.48], p < 0.001). Conclusion VIPN results in a significant reduction of HR‐QoL in children under treatment for a malignancy, which means that VIPN is important for the well‐being of pediatric oncology patients. Therefore, this study underlines the importance of optimizing treatment with VCR, thereby aiming to reduce VIPN while maintaining efficacy.
format	article
author	Mirjam E. van deVelde Marleen. H. van denBerg Gertjan J. L. Kaspers Floor C. H. Abbink Jos W. R. Twisk Inge M. van derSluis Cor van denBos Marry M. van denHeuvel‐Eibrink Heidi Segers Christophe Chantrain Jutte van derWerff Ten Bosch Leen Willems Raphaële R. L. vanLitsenburg
author_facet	Mirjam E. van deVelde Marleen. H. van denBerg Gertjan J. L. Kaspers Floor C. H. Abbink Jos W. R. Twisk Inge M. van derSluis Cor van denBos Marry M. van denHeuvel‐Eibrink Heidi Segers Christophe Chantrain Jutte van derWerff Ten Bosch Leen Willems Raphaële R. L. vanLitsenburg
author_sort	Mirjam E. van deVelde
title	The association between vincristine‐induced peripheral neuropathy and health‐related quality of life in children with cancer
title_short	The association between vincristine‐induced peripheral neuropathy and health‐related quality of life in children with cancer
title_full	The association between vincristine‐induced peripheral neuropathy and health‐related quality of life in children with cancer
title_fullStr	The association between vincristine‐induced peripheral neuropathy and health‐related quality of life in children with cancer
title_full_unstemmed	The association between vincristine‐induced peripheral neuropathy and health‐related quality of life in children with cancer
title_sort	association between vincristine‐induced peripheral neuropathy and health‐related quality of life in children with cancer
publisher	Wiley
publishDate	2021
url	https://doaj.org/article/e5e35beb568340dda7f7b38abc4d5585
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The association between vincristine‐induced peripheral neuropathy and health‐related quality of life in children with cancer

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