Toward a surrogate marker of malaria exposure: modeling longitudinal antibody measurements under outbreak conditions.
<h4>Background</h4>Biomarkers of exposure to Plasmodium falciparum would be a useful tool for the assessment of malaria burden and analysis of intervention and epidemiological studies. Antibodies to pre-erythrocytic antigens represent potential surrogates of exposure.<h4>Methods an...
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Public Library of Science (PLoS)
2011
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oai:doaj.org-article:e5e4b7a100d04bbfb5e6f4b5f66867092021-11-18T06:49:20ZToward a surrogate marker of malaria exposure: modeling longitudinal antibody measurements under outbreak conditions.1932-620310.1371/journal.pone.0021826https://doaj.org/article/e5e4b7a100d04bbfb5e6f4b5f66867092011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21818270/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Biomarkers of exposure to Plasmodium falciparum would be a useful tool for the assessment of malaria burden and analysis of intervention and epidemiological studies. Antibodies to pre-erythrocytic antigens represent potential surrogates of exposure.<h4>Methods and findings</h4>In an outbreak cohort of U.S. Marines deployed to Liberia, we modeled pre- and post-deployment IgG against P. falciparum sporozoites by immunofluorescence antibody test, and both IgG and IgM against the P. falciparum circumsporozoite protein by enzyme-linked immunosorbant assay. Modeling seroconversion thresholds by a fixed ratio, linear regression or nonlinear regression produced sensitivity for identification of exposed U.S. Marines between 58-70% and specificities between 87-97%, compared with malaria-naïve U.S. volunteers. Exposure was predicted in 30-45% of the cohort.<h4>Conclusion</h4>Each of the three models tested has merits in different studies, but further development and validation in endemic populations is required. Overall, these models provide support for an antibody-based surrogate marker of exposure to malaria.Joseph J CampoTimothy J WhitmanDaniel FreilichTimothy H BurgessGregory J MartinDenise L DoolanPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 7, p e21826 (2011) |
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Medicine R Science Q |
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Medicine R Science Q Joseph J Campo Timothy J Whitman Daniel Freilich Timothy H Burgess Gregory J Martin Denise L Doolan Toward a surrogate marker of malaria exposure: modeling longitudinal antibody measurements under outbreak conditions. |
| description |
<h4>Background</h4>Biomarkers of exposure to Plasmodium falciparum would be a useful tool for the assessment of malaria burden and analysis of intervention and epidemiological studies. Antibodies to pre-erythrocytic antigens represent potential surrogates of exposure.<h4>Methods and findings</h4>In an outbreak cohort of U.S. Marines deployed to Liberia, we modeled pre- and post-deployment IgG against P. falciparum sporozoites by immunofluorescence antibody test, and both IgG and IgM against the P. falciparum circumsporozoite protein by enzyme-linked immunosorbant assay. Modeling seroconversion thresholds by a fixed ratio, linear regression or nonlinear regression produced sensitivity for identification of exposed U.S. Marines between 58-70% and specificities between 87-97%, compared with malaria-naïve U.S. volunteers. Exposure was predicted in 30-45% of the cohort.<h4>Conclusion</h4>Each of the three models tested has merits in different studies, but further development and validation in endemic populations is required. Overall, these models provide support for an antibody-based surrogate marker of exposure to malaria. |
| format |
article |
| author |
Joseph J Campo Timothy J Whitman Daniel Freilich Timothy H Burgess Gregory J Martin Denise L Doolan |
| author_facet |
Joseph J Campo Timothy J Whitman Daniel Freilich Timothy H Burgess Gregory J Martin Denise L Doolan |
| author_sort |
Joseph J Campo |
| title |
Toward a surrogate marker of malaria exposure: modeling longitudinal antibody measurements under outbreak conditions. |
| title_short |
Toward a surrogate marker of malaria exposure: modeling longitudinal antibody measurements under outbreak conditions. |
| title_full |
Toward a surrogate marker of malaria exposure: modeling longitudinal antibody measurements under outbreak conditions. |
| title_fullStr |
Toward a surrogate marker of malaria exposure: modeling longitudinal antibody measurements under outbreak conditions. |
| title_full_unstemmed |
Toward a surrogate marker of malaria exposure: modeling longitudinal antibody measurements under outbreak conditions. |
| title_sort |
toward a surrogate marker of malaria exposure: modeling longitudinal antibody measurements under outbreak conditions. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2011 |
| url |
https://doaj.org/article/e5e4b7a100d04bbfb5e6f4b5f6686709 |
| work_keys_str_mv |
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1718424387471802368 |