Development of Graves' Disease After SARS-CoV-2 mRNA Vaccination: A Case Report and Literature Review

Background: Mounting evidence has revealed the interrelationship between thyroid and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to explain the thyroid dysfunction and autoimmune thyroid disorders observed after coronavirus disease 2019 (COVID-19). There are limited reports of thyro...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	David Tak Wai Lui, Ka Kui Lee, Chi Ho Lee, Alan Chun Hong Lee, Ivan Fan Ngai Hung, Kathryn Choon Beng Tan
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	COVID-19 SARS-CoV-2 COVID-19 vaccines Graves' disease thyroiditis autoimmunity Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/e5e5213f610948958a74cbf695c7cde6
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:e5e5213f610948958a74cbf695c7cde6
record_format	dspace
spelling	oai:doaj.org-article:e5e5213f610948958a74cbf695c7cde62021-11-30T14:07:23ZDevelopment of Graves' Disease After SARS-CoV-2 mRNA Vaccination: A Case Report and Literature Review2296-256510.3389/fpubh.2021.778964https://doaj.org/article/e5e5213f610948958a74cbf695c7cde62021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fpubh.2021.778964/fullhttps://doaj.org/toc/2296-2565Background: Mounting evidence has revealed the interrelationship between thyroid and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to explain the thyroid dysfunction and autoimmune thyroid disorders observed after coronavirus disease 2019 (COVID-19). There are limited reports of thyroid dysfunction after SARS-CoV-2 vaccination.Methods: We report a case of a 40-year-old Chinese woman who developed Graves' disease after BNT162b2 mRNA vaccine. A search of PubMed and Embase databases from 1 September 2019 to 31 August 2021 was performed using the following keywords: “COVID,” “vaccine,” “thyroid,” “thyroiditis,” and “Graves.”Results: A 40-year-old Chinese woman who had 8-year history of hypothyroidism requiring thyroxine replacement. Her anti-thyroid peroxidase and anti-thyroglobulin antibodies were negative at diagnosis. She received her first and second doses of BNT162b2 mRNA vaccine on 6 April and 1 May 2021, respectively. She developed thyrotoxicosis and was diagnosed to have Graves' disease 5 weeks after the second dose of vaccine, with positive thyroid stimulating immunoglobulin level, diffuse goiter with hypervascularity on thyroid ultrasonography and diffusely increased thyroid uptake on technetium thyroid scan. Both anti-thyroid peroxidase and anti-thyroglobulin antibodies became positive. She was treated with carbimazole. Literature search revealed four cases of Graves' disease after SARS-CoV-2 vaccination, all after mRNA vaccines; and nine cases of subacute thyroiditis, after different types of SARS-CoV-2 vaccines.Conclusion: Our case represents the fifth in the literature of Graves' disease after SARS-CoV-2 vaccination, with an unusual presentation on a longstanding history of hypothyroidism. Clinicians should remain vigilant about potential thyroid dysfunction after SARS-CoV-2 vaccination in the current pandemic.David Tak Wai LuiKa Kui LeeChi Ho LeeAlan Chun Hong LeeIvan Fan Ngai HungKathryn Choon Beng TanFrontiers Media S.A.articleCOVID-19SARS-CoV-2COVID-19 vaccinesGraves' diseasethyroiditisautoimmunityPublic aspects of medicineRA1-1270ENFrontiers in Public Health, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	COVID-19 SARS-CoV-2 COVID-19 vaccines Graves' disease thyroiditis autoimmunity Public aspects of medicine RA1-1270
spellingShingle	COVID-19 SARS-CoV-2 COVID-19 vaccines Graves' disease thyroiditis autoimmunity Public aspects of medicine RA1-1270 David Tak Wai Lui Ka Kui Lee Chi Ho Lee Alan Chun Hong Lee Ivan Fan Ngai Hung Kathryn Choon Beng Tan Development of Graves' Disease After SARS-CoV-2 mRNA Vaccination: A Case Report and Literature Review
description	Background: Mounting evidence has revealed the interrelationship between thyroid and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to explain the thyroid dysfunction and autoimmune thyroid disorders observed after coronavirus disease 2019 (COVID-19). There are limited reports of thyroid dysfunction after SARS-CoV-2 vaccination.Methods: We report a case of a 40-year-old Chinese woman who developed Graves' disease after BNT162b2 mRNA vaccine. A search of PubMed and Embase databases from 1 September 2019 to 31 August 2021 was performed using the following keywords: “COVID,” “vaccine,” “thyroid,” “thyroiditis,” and “Graves.”Results: A 40-year-old Chinese woman who had 8-year history of hypothyroidism requiring thyroxine replacement. Her anti-thyroid peroxidase and anti-thyroglobulin antibodies were negative at diagnosis. She received her first and second doses of BNT162b2 mRNA vaccine on 6 April and 1 May 2021, respectively. She developed thyrotoxicosis and was diagnosed to have Graves' disease 5 weeks after the second dose of vaccine, with positive thyroid stimulating immunoglobulin level, diffuse goiter with hypervascularity on thyroid ultrasonography and diffusely increased thyroid uptake on technetium thyroid scan. Both anti-thyroid peroxidase and anti-thyroglobulin antibodies became positive. She was treated with carbimazole. Literature search revealed four cases of Graves' disease after SARS-CoV-2 vaccination, all after mRNA vaccines; and nine cases of subacute thyroiditis, after different types of SARS-CoV-2 vaccines.Conclusion: Our case represents the fifth in the literature of Graves' disease after SARS-CoV-2 vaccination, with an unusual presentation on a longstanding history of hypothyroidism. Clinicians should remain vigilant about potential thyroid dysfunction after SARS-CoV-2 vaccination in the current pandemic.
format	article
author	David Tak Wai Lui Ka Kui Lee Chi Ho Lee Alan Chun Hong Lee Ivan Fan Ngai Hung Kathryn Choon Beng Tan
author_facet	David Tak Wai Lui Ka Kui Lee Chi Ho Lee Alan Chun Hong Lee Ivan Fan Ngai Hung Kathryn Choon Beng Tan
author_sort	David Tak Wai Lui
title	Development of Graves' Disease After SARS-CoV-2 mRNA Vaccination: A Case Report and Literature Review
title_short	Development of Graves' Disease After SARS-CoV-2 mRNA Vaccination: A Case Report and Literature Review
title_full	Development of Graves' Disease After SARS-CoV-2 mRNA Vaccination: A Case Report and Literature Review
title_fullStr	Development of Graves' Disease After SARS-CoV-2 mRNA Vaccination: A Case Report and Literature Review
title_full_unstemmed	Development of Graves' Disease After SARS-CoV-2 mRNA Vaccination: A Case Report and Literature Review
title_sort	development of graves' disease after sars-cov-2 mrna vaccination: a case report and literature review
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/e5e5213f610948958a74cbf695c7cde6
work_keys_str_mv	AT davidtakwailui developmentofgravesdiseaseaftersarscov2mrnavaccinationacasereportandliteraturereview AT kakuilee developmentofgravesdiseaseaftersarscov2mrnavaccinationacasereportandliteraturereview AT chiholee developmentofgravesdiseaseaftersarscov2mrnavaccinationacasereportandliteraturereview AT alanchunhonglee developmentofgravesdiseaseaftersarscov2mrnavaccinationacasereportandliteraturereview AT ivanfanngaihung developmentofgravesdiseaseaftersarscov2mrnavaccinationacasereportandliteraturereview AT kathrynchoonbengtan developmentofgravesdiseaseaftersarscov2mrnavaccinationacasereportandliteraturereview
_version_	1718406536438480896

Development of Graves' Disease After SARS-CoV-2 mRNA Vaccination: A Case Report and Literature Review

Ejemplares similares