Beneficial Effects on Brain Micro-Environment by Caloric Restriction in Alleviating Neurodegenerative Diseases and Brain Aging
Aging and neurodegenerative diseases are frequently associated with the disruption of the extracellular microenvironment, which includes mesenchyme and body fluid components. Caloric restriction (CR) has been recognized as a lifestyle intervention that can improve long-term health. In addition to pr...
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Frontiers Media S.A.
2021
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oai:doaj.org-article:e5e74c46a5d047a295fbf756210975872021-12-01T01:58:56ZBeneficial Effects on Brain Micro-Environment by Caloric Restriction in Alleviating Neurodegenerative Diseases and Brain Aging1664-042X10.3389/fphys.2021.715443https://doaj.org/article/e5e74c46a5d047a295fbf756210975872021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphys.2021.715443/fullhttps://doaj.org/toc/1664-042XAging and neurodegenerative diseases are frequently associated with the disruption of the extracellular microenvironment, which includes mesenchyme and body fluid components. Caloric restriction (CR) has been recognized as a lifestyle intervention that can improve long-term health. In addition to preventing metabolic disorders, CR has been shown to improve brain health owing to its enhancing effect on cognitive functions or retarding effect on the progression of neurodegenerative diseases. This article summarizes current findings regarding the neuroprotective effects of CR, which include the modulation of metabolism, autophagy, oxidative stress, and neuroinflammation. This review may offer future perspectives for brain aging interventions.Li ZhangLi ZhangLi ZhangLi ZhangHuachong XuNing DingNing DingXue LiXiaoyin ChenZhuangfei ChenFrontiers Media S.A.articlebrain agingextracellular microenvironmentneuroinflammationcognitive functionsmetabolic homeostasisPhysiologyQP1-981ENFrontiers in Physiology, Vol 12 (2021) |
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brain aging extracellular microenvironment neuroinflammation cognitive functions metabolic homeostasis Physiology QP1-981 |
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brain aging extracellular microenvironment neuroinflammation cognitive functions metabolic homeostasis Physiology QP1-981 Li Zhang Li Zhang Li Zhang Li Zhang Huachong Xu Ning Ding Ning Ding Xue Li Xiaoyin Chen Zhuangfei Chen Beneficial Effects on Brain Micro-Environment by Caloric Restriction in Alleviating Neurodegenerative Diseases and Brain Aging |
description |
Aging and neurodegenerative diseases are frequently associated with the disruption of the extracellular microenvironment, which includes mesenchyme and body fluid components. Caloric restriction (CR) has been recognized as a lifestyle intervention that can improve long-term health. In addition to preventing metabolic disorders, CR has been shown to improve brain health owing to its enhancing effect on cognitive functions or retarding effect on the progression of neurodegenerative diseases. This article summarizes current findings regarding the neuroprotective effects of CR, which include the modulation of metabolism, autophagy, oxidative stress, and neuroinflammation. This review may offer future perspectives for brain aging interventions. |
format |
article |
author |
Li Zhang Li Zhang Li Zhang Li Zhang Huachong Xu Ning Ding Ning Ding Xue Li Xiaoyin Chen Zhuangfei Chen |
author_facet |
Li Zhang Li Zhang Li Zhang Li Zhang Huachong Xu Ning Ding Ning Ding Xue Li Xiaoyin Chen Zhuangfei Chen |
author_sort |
Li Zhang |
title |
Beneficial Effects on Brain Micro-Environment by Caloric Restriction in Alleviating Neurodegenerative Diseases and Brain Aging |
title_short |
Beneficial Effects on Brain Micro-Environment by Caloric Restriction in Alleviating Neurodegenerative Diseases and Brain Aging |
title_full |
Beneficial Effects on Brain Micro-Environment by Caloric Restriction in Alleviating Neurodegenerative Diseases and Brain Aging |
title_fullStr |
Beneficial Effects on Brain Micro-Environment by Caloric Restriction in Alleviating Neurodegenerative Diseases and Brain Aging |
title_full_unstemmed |
Beneficial Effects on Brain Micro-Environment by Caloric Restriction in Alleviating Neurodegenerative Diseases and Brain Aging |
title_sort |
beneficial effects on brain micro-environment by caloric restriction in alleviating neurodegenerative diseases and brain aging |
publisher |
Frontiers Media S.A. |
publishDate |
2021 |
url |
https://doaj.org/article/e5e74c46a5d047a295fbf75621097587 |
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