Beneficial Effects on Brain Micro-Environment by Caloric Restriction in Alleviating Neurodegenerative Diseases and Brain Aging

Aging and neurodegenerative diseases are frequently associated with the disruption of the extracellular microenvironment, which includes mesenchyme and body fluid components. Caloric restriction (CR) has been recognized as a lifestyle intervention that can improve long-term health. In addition to pr...

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Autores principales: Li Zhang, Huachong Xu, Ning Ding, Xue Li, Xiaoyin Chen, Zhuangfei Chen
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Lenguaje:EN
Publicado: Frontiers Media S.A. 2021
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Acceso en línea:https://doaj.org/article/e5e74c46a5d047a295fbf75621097587
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spelling oai:doaj.org-article:e5e74c46a5d047a295fbf756210975872021-12-01T01:58:56ZBeneficial Effects on Brain Micro-Environment by Caloric Restriction in Alleviating Neurodegenerative Diseases and Brain Aging1664-042X10.3389/fphys.2021.715443https://doaj.org/article/e5e74c46a5d047a295fbf756210975872021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fphys.2021.715443/fullhttps://doaj.org/toc/1664-042XAging and neurodegenerative diseases are frequently associated with the disruption of the extracellular microenvironment, which includes mesenchyme and body fluid components. Caloric restriction (CR) has been recognized as a lifestyle intervention that can improve long-term health. In addition to preventing metabolic disorders, CR has been shown to improve brain health owing to its enhancing effect on cognitive functions or retarding effect on the progression of neurodegenerative diseases. This article summarizes current findings regarding the neuroprotective effects of CR, which include the modulation of metabolism, autophagy, oxidative stress, and neuroinflammation. This review may offer future perspectives for brain aging interventions.Li ZhangLi ZhangLi ZhangLi ZhangHuachong XuNing DingNing DingXue LiXiaoyin ChenZhuangfei ChenFrontiers Media S.A.articlebrain agingextracellular microenvironmentneuroinflammationcognitive functionsmetabolic homeostasisPhysiologyQP1-981ENFrontiers in Physiology, Vol 12 (2021)
institution DOAJ
collection DOAJ
language EN
topic brain aging
extracellular microenvironment
neuroinflammation
cognitive functions
metabolic homeostasis
Physiology
QP1-981
spellingShingle brain aging
extracellular microenvironment
neuroinflammation
cognitive functions
metabolic homeostasis
Physiology
QP1-981
Li Zhang
Li Zhang
Li Zhang
Li Zhang
Huachong Xu
Ning Ding
Ning Ding
Xue Li
Xiaoyin Chen
Zhuangfei Chen
Beneficial Effects on Brain Micro-Environment by Caloric Restriction in Alleviating Neurodegenerative Diseases and Brain Aging
description Aging and neurodegenerative diseases are frequently associated with the disruption of the extracellular microenvironment, which includes mesenchyme and body fluid components. Caloric restriction (CR) has been recognized as a lifestyle intervention that can improve long-term health. In addition to preventing metabolic disorders, CR has been shown to improve brain health owing to its enhancing effect on cognitive functions or retarding effect on the progression of neurodegenerative diseases. This article summarizes current findings regarding the neuroprotective effects of CR, which include the modulation of metabolism, autophagy, oxidative stress, and neuroinflammation. This review may offer future perspectives for brain aging interventions.
format article
author Li Zhang
Li Zhang
Li Zhang
Li Zhang
Huachong Xu
Ning Ding
Ning Ding
Xue Li
Xiaoyin Chen
Zhuangfei Chen
author_facet Li Zhang
Li Zhang
Li Zhang
Li Zhang
Huachong Xu
Ning Ding
Ning Ding
Xue Li
Xiaoyin Chen
Zhuangfei Chen
author_sort Li Zhang
title Beneficial Effects on Brain Micro-Environment by Caloric Restriction in Alleviating Neurodegenerative Diseases and Brain Aging
title_short Beneficial Effects on Brain Micro-Environment by Caloric Restriction in Alleviating Neurodegenerative Diseases and Brain Aging
title_full Beneficial Effects on Brain Micro-Environment by Caloric Restriction in Alleviating Neurodegenerative Diseases and Brain Aging
title_fullStr Beneficial Effects on Brain Micro-Environment by Caloric Restriction in Alleviating Neurodegenerative Diseases and Brain Aging
title_full_unstemmed Beneficial Effects on Brain Micro-Environment by Caloric Restriction in Alleviating Neurodegenerative Diseases and Brain Aging
title_sort beneficial effects on brain micro-environment by caloric restriction in alleviating neurodegenerative diseases and brain aging
publisher Frontiers Media S.A.
publishDate 2021
url https://doaj.org/article/e5e74c46a5d047a295fbf75621097587
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