Cyclodextrin-Appended Superparamagnetic Iron Oxide Nanoparticles as Cholesterol-Mopping Agents

Cholesterol plays a crucial role in major cardiovascular and neurodegenerative diseases, including Alzheimer’s disease and rare genetic disorders showing altered cholesterol metabolism. Cyclodextrins (CDs) have shown promising therapeutic efficacy based on their capacity to sequester and mobilise ch...

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Autores principales:	Antonino Puglisi, Simone Bassini, Erik Reimhult
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	cholesterol cyclodextrin SPION core-shell nanoparticles nanoparticles Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/e5e84b09d59b4e81b8910a2b65724af3
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spelling	oai:doaj.org-article:e5e84b09d59b4e81b8910a2b65724af32021-11-18T06:03:48ZCyclodextrin-Appended Superparamagnetic Iron Oxide Nanoparticles as Cholesterol-Mopping Agents2296-264610.3389/fchem.2021.795598https://doaj.org/article/e5e84b09d59b4e81b8910a2b65724af32021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fchem.2021.795598/fullhttps://doaj.org/toc/2296-2646Cholesterol plays a crucial role in major cardiovascular and neurodegenerative diseases, including Alzheimer’s disease and rare genetic disorders showing altered cholesterol metabolism. Cyclodextrins (CDs) have shown promising therapeutic efficacy based on their capacity to sequester and mobilise cholesterol. However, the administration of monomeric CDs suffers from several drawbacks due to their lack of specificity and poor pharmacokinetics. We present core-shell superparamagnetic iron oxide nanoparticles (SPIONs) functionalised with CDs appended to poly (2-methyl-2-oxazoline) polymers grafted in a dense brush to the iron oxide core. The CD-decorated nanoparticles (CySPIONs) are designed so that the macrocycle is specifically cleaved off the nanoparticle’s shell at a slightly acidic pH. In the intended use, free monomeric CDs will then mobilise cholesterol out of the lysosome to the cytosol and beyond through the formation of an inclusion complex. Hence, its suitability as a therapeutic platform to remove cholesterol in the lysosomal compartment. Synthesis and full characterization of the polymer as well as of the core-shell SPION are presented. Cholesterol-binding activity is shown through an enzymatic assay.Antonino PuglisiSimone BassiniSimone BassiniErik ReimhultFrontiers Media S.A.articlecholesterolcyclodextrinSPIONcore-shell nanoparticlesnanoparticlesChemistryQD1-999ENFrontiers in Chemistry, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cholesterol cyclodextrin SPION core-shell nanoparticles nanoparticles Chemistry QD1-999
spellingShingle	cholesterol cyclodextrin SPION core-shell nanoparticles nanoparticles Chemistry QD1-999 Antonino Puglisi Simone Bassini Simone Bassini Erik Reimhult Cyclodextrin-Appended Superparamagnetic Iron Oxide Nanoparticles as Cholesterol-Mopping Agents
description	Cholesterol plays a crucial role in major cardiovascular and neurodegenerative diseases, including Alzheimer’s disease and rare genetic disorders showing altered cholesterol metabolism. Cyclodextrins (CDs) have shown promising therapeutic efficacy based on their capacity to sequester and mobilise cholesterol. However, the administration of monomeric CDs suffers from several drawbacks due to their lack of specificity and poor pharmacokinetics. We present core-shell superparamagnetic iron oxide nanoparticles (SPIONs) functionalised with CDs appended to poly (2-methyl-2-oxazoline) polymers grafted in a dense brush to the iron oxide core. The CD-decorated nanoparticles (CySPIONs) are designed so that the macrocycle is specifically cleaved off the nanoparticle’s shell at a slightly acidic pH. In the intended use, free monomeric CDs will then mobilise cholesterol out of the lysosome to the cytosol and beyond through the formation of an inclusion complex. Hence, its suitability as a therapeutic platform to remove cholesterol in the lysosomal compartment. Synthesis and full characterization of the polymer as well as of the core-shell SPION are presented. Cholesterol-binding activity is shown through an enzymatic assay.
format	article
author	Antonino Puglisi Simone Bassini Simone Bassini Erik Reimhult
author_facet	Antonino Puglisi Simone Bassini Simone Bassini Erik Reimhult
author_sort	Antonino Puglisi
title	Cyclodextrin-Appended Superparamagnetic Iron Oxide Nanoparticles as Cholesterol-Mopping Agents
title_short	Cyclodextrin-Appended Superparamagnetic Iron Oxide Nanoparticles as Cholesterol-Mopping Agents
title_full	Cyclodextrin-Appended Superparamagnetic Iron Oxide Nanoparticles as Cholesterol-Mopping Agents
title_fullStr	Cyclodextrin-Appended Superparamagnetic Iron Oxide Nanoparticles as Cholesterol-Mopping Agents
title_full_unstemmed	Cyclodextrin-Appended Superparamagnetic Iron Oxide Nanoparticles as Cholesterol-Mopping Agents
title_sort	cyclodextrin-appended superparamagnetic iron oxide nanoparticles as cholesterol-mopping agents
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/e5e84b09d59b4e81b8910a2b65724af3
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Cyclodextrin-Appended Superparamagnetic Iron Oxide Nanoparticles as Cholesterol-Mopping Agents

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