Parallel evolution in the emergence of highly pathogenic avian influenza A viruses

Highly pathogenic avian influenza viruses (HPAIV) can evolve via acquisition of polybasic cleavage sites, but the contribution of other mutations remains unclear. Here, the authors combine phylogenetic, statistical and structural approaches, and identify parallel mutations that are associated with H...

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Autores principales:	Marina Escalera-Zamudio, Michael Golden, Bernardo Gutiérrez, Julien Thézé, Jeremy Russell Keown, Loic Carrique, Thomas A. Bowden, Oliver G. Pybus
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e5ea426da8054ddd9dbfead64f616866
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spelling	oai:doaj.org-article:e5ea426da8054ddd9dbfead64f6168662021-12-02T15:37:12ZParallel evolution in the emergence of highly pathogenic avian influenza A viruses10.1038/s41467-020-19364-x2041-1723https://doaj.org/article/e5ea426da8054ddd9dbfead64f6168662020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19364-xhttps://doaj.org/toc/2041-1723Highly pathogenic avian influenza viruses (HPAIV) can evolve via acquisition of polybasic cleavage sites, but the contribution of other mutations remains unclear. Here, the authors combine phylogenetic, statistical and structural approaches, and identify parallel mutations that are associated with HPAIV phenotype.Marina Escalera-ZamudioMichael GoldenBernardo GutiérrezJulien ThézéJeremy Russell KeownLoic CarriqueThomas A. BowdenOliver G. PybusNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Marina Escalera-Zamudio Michael Golden Bernardo Gutiérrez Julien Thézé Jeremy Russell Keown Loic Carrique Thomas A. Bowden Oliver G. Pybus Parallel evolution in the emergence of highly pathogenic avian influenza A viruses
description	Highly pathogenic avian influenza viruses (HPAIV) can evolve via acquisition of polybasic cleavage sites, but the contribution of other mutations remains unclear. Here, the authors combine phylogenetic, statistical and structural approaches, and identify parallel mutations that are associated with HPAIV phenotype.
format	article
author	Marina Escalera-Zamudio Michael Golden Bernardo Gutiérrez Julien Thézé Jeremy Russell Keown Loic Carrique Thomas A. Bowden Oliver G. Pybus
author_facet	Marina Escalera-Zamudio Michael Golden Bernardo Gutiérrez Julien Thézé Jeremy Russell Keown Loic Carrique Thomas A. Bowden Oliver G. Pybus
author_sort	Marina Escalera-Zamudio
title	Parallel evolution in the emergence of highly pathogenic avian influenza A viruses
title_short	Parallel evolution in the emergence of highly pathogenic avian influenza A viruses
title_full	Parallel evolution in the emergence of highly pathogenic avian influenza A viruses
title_fullStr	Parallel evolution in the emergence of highly pathogenic avian influenza A viruses
title_full_unstemmed	Parallel evolution in the emergence of highly pathogenic avian influenza A viruses
title_sort	parallel evolution in the emergence of highly pathogenic avian influenza a viruses
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/e5ea426da8054ddd9dbfead64f616866
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Parallel evolution in the emergence of highly pathogenic avian influenza A viruses

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