Prefrontal cortical activity predicts the occurrence of nonlocal hippocampal representations during spatial navigation.

The receptive field of a neuron describes the regions of a stimulus space where the neuron is consistently active. Sparse spiking outside of the receptive field is often considered to be noise, rather than a reflection of information processing. Whether this characterization is accurate remains uncl...

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Autores principales:	Jai Y Yu, Loren M Frank
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/e5ebddfb655248fcb9fda0cd214302d8
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id	oai:doaj.org-article:e5ebddfb655248fcb9fda0cd214302d8
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spelling	oai:doaj.org-article:e5ebddfb655248fcb9fda0cd214302d82021-12-02T19:54:35ZPrefrontal cortical activity predicts the occurrence of nonlocal hippocampal representations during spatial navigation.1544-91731545-788510.1371/journal.pbio.3001393https://doaj.org/article/e5ebddfb655248fcb9fda0cd214302d82021-09-01T00:00:00Zhttps://doi.org/10.1371/journal.pbio.3001393https://doaj.org/toc/1544-9173https://doaj.org/toc/1545-7885The receptive field of a neuron describes the regions of a stimulus space where the neuron is consistently active. Sparse spiking outside of the receptive field is often considered to be noise, rather than a reflection of information processing. Whether this characterization is accurate remains unclear. We therefore contrasted the sparse, temporally isolated spiking of hippocampal CA1 place cells to the consistent, temporally adjacent spiking seen within their spatial receptive fields ("place fields"). We found that isolated spikes, which occur during locomotion, are strongly phase coupled to hippocampal theta oscillations and transiently express coherent nonlocal spatial representations. Further, prefrontal cortical activity is coordinated with and can predict the occurrence of future isolated spiking events. Rather than local noise within the hippocampus, sparse, isolated place cell spiking reflects a coordinated cortical-hippocampal process consistent with the generation of nonlocal scenario representations during active navigation.Jai Y YuLoren M FrankPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Biology, Vol 19, Iss 9, p e3001393 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Jai Y Yu Loren M Frank Prefrontal cortical activity predicts the occurrence of nonlocal hippocampal representations during spatial navigation.
description	The receptive field of a neuron describes the regions of a stimulus space where the neuron is consistently active. Sparse spiking outside of the receptive field is often considered to be noise, rather than a reflection of information processing. Whether this characterization is accurate remains unclear. We therefore contrasted the sparse, temporally isolated spiking of hippocampal CA1 place cells to the consistent, temporally adjacent spiking seen within their spatial receptive fields ("place fields"). We found that isolated spikes, which occur during locomotion, are strongly phase coupled to hippocampal theta oscillations and transiently express coherent nonlocal spatial representations. Further, prefrontal cortical activity is coordinated with and can predict the occurrence of future isolated spiking events. Rather than local noise within the hippocampus, sparse, isolated place cell spiking reflects a coordinated cortical-hippocampal process consistent with the generation of nonlocal scenario representations during active navigation.
format	article
author	Jai Y Yu Loren M Frank
author_facet	Jai Y Yu Loren M Frank
author_sort	Jai Y Yu
title	Prefrontal cortical activity predicts the occurrence of nonlocal hippocampal representations during spatial navigation.
title_short	Prefrontal cortical activity predicts the occurrence of nonlocal hippocampal representations during spatial navigation.
title_full	Prefrontal cortical activity predicts the occurrence of nonlocal hippocampal representations during spatial navigation.
title_fullStr	Prefrontal cortical activity predicts the occurrence of nonlocal hippocampal representations during spatial navigation.
title_full_unstemmed	Prefrontal cortical activity predicts the occurrence of nonlocal hippocampal representations during spatial navigation.
title_sort	prefrontal cortical activity predicts the occurrence of nonlocal hippocampal representations during spatial navigation.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/e5ebddfb655248fcb9fda0cd214302d8
work_keys_str_mv	AT jaiyyu prefrontalcorticalactivitypredictstheoccurrenceofnonlocalhippocampalrepresentationsduringspatialnavigation AT lorenmfrank prefrontalcorticalactivitypredictstheoccurrenceofnonlocalhippocampalrepresentationsduringspatialnavigation
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Prefrontal cortical activity predicts the occurrence of nonlocal hippocampal representations during spatial navigation.

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