Excessive Daytime Sleepiness and Cardiovascular Mortality in US Adults: A NHANES 2005–2008 Follow-Up Study

Excessive Daytime Sleepiness and Cardiovascular Mortality in US Adults: A NHANES 2005–2008 Follow-Up Study

Jingen Li,1,2 Naima Covassin,2 Joshua M Bock,2 Essa A Mohamed,2 Lakshmi P Pappoppula,2 Chilsia Shafi,2 Francisco Lopez-Jimenez,2 Virend K Somers2 1Department of Cardiovascular Medicine, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, 100700, People’s Republic of China; 2Departm...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Li J, Covassin N, Bock JM, Mohamed EA, Pappoppula LP, Shafi C, Lopez-Jimenez F, Somers VK
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2021
Materias:
sleep disorders
cardiovascular diseases
cardiovascular risk
cohort study
Psychiatry
RC435-571
Neurophysiology and neuropsychology
QP351-495
Acceso en línea:https://doaj.org/article/e5edb0bd94c0444d8254698b54c907ac
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:e5edb0bd94c0444d8254698b54c907ac
record_format dspace
spelling oai:doaj.org-article:e5edb0bd94c0444d8254698b54c907ac2021-12-02T16:29:38ZExcessive Daytime Sleepiness and Cardiovascular Mortality in US Adults: A NHANES 2005–2008 Follow-Up Study1179-1608https://doaj.org/article/e5edb0bd94c0444d8254698b54c907ac2021-07-01T00:00:00Zhttps://www.dovepress.com/excessive-daytime-sleepiness-and-cardiovascular-mortality-in-us-adults-peer-reviewed-fulltext-article-NSShttps://doaj.org/toc/1179-1608Jingen Li,1,2 Naima Covassin,2 Joshua M Bock,2 Essa A Mohamed,2 Lakshmi P Pappoppula,2 Chilsia Shafi,2 Francisco Lopez-Jimenez,2 Virend K Somers2 1Department of Cardiovascular Medicine, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, 100700, People’s Republic of China; 2Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, 55902, USACorrespondence: Virend K SomersDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, 55902, USATel +1 507 2842511Email somers.virend@mayo.eduPurpose: Excessive daytime sleepiness is highly prevalent and has been associated with increased risk of cardiovascular diseases, but evidence for its association with cardiovascular mortality is limited and inconsistent. We aimed to determine whether excessive daytime sleepiness is independently associated with cardiovascular mortality in general adult population.Patients and Methods: A prospective study of 10,330 adult participants (aged ≥ 20 years) from National Health and Nutrition Examination Survey (NHANES) 2005– 2006 and 2007– 2008 was followed up until December 31st, 2015. Excessive daytime sleepiness was defined as the self-reported feeling of being overly sleepy often or always during the day. Cox proportional hazard ratios (HRs) with 95% confidence interval (CI) were estimated to assess risk for cardiovascular mortality.Results: A total of 10,330 participants with mean age of 47.3 years (95% CI, 46.0 to 48.1) were included in this analysis. Approximately, 18.5% of US adults reported excessive daytime sleepiness. Over a mean follow-up of 8.3 years, 262 cardiovascular deaths occurred. Participants with excessive daytime sleepiness had 2.85-times greater risk (95% CI, 1.33– 6.09) of cardiovascular death than those without daytime sleepiness in multivariable analysis corrected for sociodemographic factors, comorbidities and cardiovascular risk factors including depression. Further adjustment for self-reported sleep disorders and sleep duration only slightly attenuated this association (HR, 2.55; 95% CI, 1.23– 5.27). No interactions between excessive daytime sleepiness and age, sex or cardiovascular disease at study entry were observed (all Ps> 0.05).Conclusion: Excessive daytime sleepiness is highly prevalent among US adults and is independently associated with an approximately two-and-a-half-fold increased risk of cardiovascular mortality in a large national sample. Screening for excessive daytime sleepiness may be a simple and cost-effective tool for identifying individuals at high risk of cardiovascular death.Keywords: sleep disorders, cardiovascular diseases, cardiovascular risk, cohort studyLi JCovassin NBock JMMohamed EAPappoppula LPShafi CLopez-Jimenez FSomers VKDove Medical Pressarticlesleep disorderscardiovascular diseasescardiovascular riskcohort studyPsychiatryRC435-571Neurophysiology and neuropsychologyQP351-495ENNature and Science of Sleep, Vol Volume 13, Pp 1049-1059 (2021)
institution DOAJ
collection DOAJ
language EN
topic sleep disorders
cardiovascular diseases
cardiovascular risk
cohort study
Psychiatry
RC435-571
Neurophysiology and neuropsychology
QP351-495
spellingShingle sleep disorders
cardiovascular diseases
cardiovascular risk
cohort study
Psychiatry
RC435-571
Neurophysiology and neuropsychology
QP351-495
Li J
Covassin N
Bock JM
Mohamed EA
Pappoppula LP
Shafi C
Lopez-Jimenez F
Somers VK
Excessive Daytime Sleepiness and Cardiovascular Mortality in US Adults: A NHANES 2005–2008 Follow-Up Study
description Jingen Li,1,2 Naima Covassin,2 Joshua M Bock,2 Essa A Mohamed,2 Lakshmi P Pappoppula,2 Chilsia Shafi,2 Francisco Lopez-Jimenez,2 Virend K Somers2 1Department of Cardiovascular Medicine, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, 100700, People’s Republic of China; 2Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, 55902, USACorrespondence: Virend K SomersDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, 55902, USATel +1 507 2842511Email somers.virend@mayo.eduPurpose: Excessive daytime sleepiness is highly prevalent and has been associated with increased risk of cardiovascular diseases, but evidence for its association with cardiovascular mortality is limited and inconsistent. We aimed to determine whether excessive daytime sleepiness is independently associated with cardiovascular mortality in general adult population.Patients and Methods: A prospective study of 10,330 adult participants (aged ≥ 20 years) from National Health and Nutrition Examination Survey (NHANES) 2005– 2006 and 2007– 2008 was followed up until December 31st, 2015. Excessive daytime sleepiness was defined as the self-reported feeling of being overly sleepy often or always during the day. Cox proportional hazard ratios (HRs) with 95% confidence interval (CI) were estimated to assess risk for cardiovascular mortality.Results: A total of 10,330 participants with mean age of 47.3 years (95% CI, 46.0 to 48.1) were included in this analysis. Approximately, 18.5% of US adults reported excessive daytime sleepiness. Over a mean follow-up of 8.3 years, 262 cardiovascular deaths occurred. Participants with excessive daytime sleepiness had 2.85-times greater risk (95% CI, 1.33– 6.09) of cardiovascular death than those without daytime sleepiness in multivariable analysis corrected for sociodemographic factors, comorbidities and cardiovascular risk factors including depression. Further adjustment for self-reported sleep disorders and sleep duration only slightly attenuated this association (HR, 2.55; 95% CI, 1.23– 5.27). No interactions between excessive daytime sleepiness and age, sex or cardiovascular disease at study entry were observed (all Ps> 0.05).Conclusion: Excessive daytime sleepiness is highly prevalent among US adults and is independently associated with an approximately two-and-a-half-fold increased risk of cardiovascular mortality in a large national sample. Screening for excessive daytime sleepiness may be a simple and cost-effective tool for identifying individuals at high risk of cardiovascular death.Keywords: sleep disorders, cardiovascular diseases, cardiovascular risk, cohort study
format article
author Li J
Covassin N
Bock JM
Mohamed EA
Pappoppula LP
Shafi C
Lopez-Jimenez F
Somers VK
author_facet Li J
Covassin N
Bock JM
Mohamed EA
Pappoppula LP
Shafi C
Lopez-Jimenez F
Somers VK
author_sort Li J
title Excessive Daytime Sleepiness and Cardiovascular Mortality in US Adults: A NHANES 2005–2008 Follow-Up Study
title_short Excessive Daytime Sleepiness and Cardiovascular Mortality in US Adults: A NHANES 2005–2008 Follow-Up Study
title_full Excessive Daytime Sleepiness and Cardiovascular Mortality in US Adults: A NHANES 2005–2008 Follow-Up Study
title_fullStr Excessive Daytime Sleepiness and Cardiovascular Mortality in US Adults: A NHANES 2005–2008 Follow-Up Study
title_full_unstemmed Excessive Daytime Sleepiness and Cardiovascular Mortality in US Adults: A NHANES 2005–2008 Follow-Up Study
title_sort excessive daytime sleepiness and cardiovascular mortality in us adults: a nhanes 2005–2008 follow-up study
publisher Dove Medical Press
publishDate 2021
url https://doaj.org/article/e5edb0bd94c0444d8254698b54c907ac
work_keys_str_mv AT lij excessivedaytimesleepinessandcardiovascularmortalityinusadultsanhanes2005ndash2008followupstudy
AT covassinn excessivedaytimesleepinessandcardiovascularmortalityinusadultsanhanes2005ndash2008followupstudy
AT bockjm excessivedaytimesleepinessandcardiovascularmortalityinusadultsanhanes2005ndash2008followupstudy
AT mohamedea excessivedaytimesleepinessandcardiovascularmortalityinusadultsanhanes2005ndash2008followupstudy
AT pappoppulalp excessivedaytimesleepinessandcardiovascularmortalityinusadultsanhanes2005ndash2008followupstudy
AT shafic excessivedaytimesleepinessandcardiovascularmortalityinusadultsanhanes2005ndash2008followupstudy
AT lopezjimenezf excessivedaytimesleepinessandcardiovascularmortalityinusadultsanhanes2005ndash2008followupstudy
AT somersvk excessivedaytimesleepinessandcardiovascularmortalityinusadultsanhanes2005ndash2008followupstudy
_version_ 1718383965661822976

Ejemplares similares