Effects of Carbidopa Premedication on 18F-FDOPA PET Imaging of Glioma: A Multiparametric Analysis

Purpose: This study aimed to determine the impact of carbidopa premedication on static, dynamic and radiomics parameters of 18F-FDOPA PET in brain tumors. Methods: The study included 54 patients, 18 of whom received carbidopa, who underwent 18F-FDOPA PET...

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Autores principales:	Marie Bros, Timothée Zaragori, Fabien Rech, Marie Blonski, Gabriela Hossu, Luc Taillandier, Pierre-Yves Marie, Antoine Verger
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	DOPA PET carbidopa glioma dynamic radiomics Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/e5ef4850102e4b4e99bb04af7da0c816
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spelling	oai:doaj.org-article:e5ef4850102e4b4e99bb04af7da0c8162021-11-11T15:28:42ZEffects of Carbidopa Premedication on <sup>18</sup>F-FDOPA PET Imaging of Glioma: A Multiparametric Analysis10.3390/cancers132153402072-6694https://doaj.org/article/e5ef4850102e4b4e99bb04af7da0c8162021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/21/5340https://doaj.org/toc/2072-6694Purpose: This study aimed to determine the impact of carbidopa premedication on static, dynamic and radiomics parameters of <sup>18</sup>F-FDOPA PET in brain tumors. Methods: The study included 54 patients, 18 of whom received carbidopa, who underwent <sup>18</sup>F-FDOPA PET for newly diagnosed gliomas. SUV-derived, 105 radiomics features and TTP dynamic parameters were extracted from volumes of interest in healthy brains and tumors. Simulation of the effects of carbidopa on time-activity curves were generated. Results: All static and TTP dynamic parameters were significantly higher in healthy brain regions of premedicated patients (ΔSUV<sub>mean</sub> = +53%, ΔTTP = +48%, <i>p</i> < 0.001). Furthermore, carbidopa impacted 81% of radiomics features, of which 92% correlated with SUV<sub>mean</sub> (absolute correlation coefficient ≥ 0.4). In tumors, premedication with carbidopa was an independent predictor of SUV<sub>mean</sub> (ΔSUV<sub>mean</sub> = +52%, <i>p</i> < 0.001) and TTP (ΔTTP = +24%, <i>p</i> = 0.025). All parameters were no longer significantly modified by carbidopa premedication when using ratios to healthy brain. Simulated data confirmed that carbidopa leads to higher tumor TTP values, corrected by the ratios. Conclusion: In <sup>18</sup>F-FDOPA PET, carbidopa induces similarly higher SUV and TTP dynamic parameters and similarly impacts SUV-dependent radiomics in healthy brain and tumor regions, which is compensated for by correcting for the tumor-to-healthy-brain ratio. This is a significant advantage for multicentric study harmonization.Marie BrosTimothée ZaragoriFabien RechMarie BlonskiGabriela HossuLuc TaillandierPierre-Yves MarieAntoine VergerMDPI AGarticleDOPAPETcarbidopagliomadynamicradiomicsNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5340, p 5340 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	DOPA PET carbidopa glioma dynamic radiomics Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	DOPA PET carbidopa glioma dynamic radiomics Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Marie Bros Timothée Zaragori Fabien Rech Marie Blonski Gabriela Hossu Luc Taillandier Pierre-Yves Marie Antoine Verger Effects of Carbidopa Premedication on <sup>18</sup>F-FDOPA PET Imaging of Glioma: A Multiparametric Analysis
description	Purpose: This study aimed to determine the impact of carbidopa premedication on static, dynamic and radiomics parameters of <sup>18</sup>F-FDOPA PET in brain tumors. Methods: The study included 54 patients, 18 of whom received carbidopa, who underwent <sup>18</sup>F-FDOPA PET for newly diagnosed gliomas. SUV-derived, 105 radiomics features and TTP dynamic parameters were extracted from volumes of interest in healthy brains and tumors. Simulation of the effects of carbidopa on time-activity curves were generated. Results: All static and TTP dynamic parameters were significantly higher in healthy brain regions of premedicated patients (ΔSUV<sub>mean</sub> = +53%, ΔTTP = +48%, <i>p</i> < 0.001). Furthermore, carbidopa impacted 81% of radiomics features, of which 92% correlated with SUV<sub>mean</sub> (absolute correlation coefficient ≥ 0.4). In tumors, premedication with carbidopa was an independent predictor of SUV<sub>mean</sub> (ΔSUV<sub>mean</sub> = +52%, <i>p</i> < 0.001) and TTP (ΔTTP = +24%, <i>p</i> = 0.025). All parameters were no longer significantly modified by carbidopa premedication when using ratios to healthy brain. Simulated data confirmed that carbidopa leads to higher tumor TTP values, corrected by the ratios. Conclusion: In <sup>18</sup>F-FDOPA PET, carbidopa induces similarly higher SUV and TTP dynamic parameters and similarly impacts SUV-dependent radiomics in healthy brain and tumor regions, which is compensated for by correcting for the tumor-to-healthy-brain ratio. This is a significant advantage for multicentric study harmonization.
format	article
author	Marie Bros Timothée Zaragori Fabien Rech Marie Blonski Gabriela Hossu Luc Taillandier Pierre-Yves Marie Antoine Verger
author_facet	Marie Bros Timothée Zaragori Fabien Rech Marie Blonski Gabriela Hossu Luc Taillandier Pierre-Yves Marie Antoine Verger
author_sort	Marie Bros
title	Effects of Carbidopa Premedication on <sup>18</sup>F-FDOPA PET Imaging of Glioma: A Multiparametric Analysis
title_short	Effects of Carbidopa Premedication on <sup>18</sup>F-FDOPA PET Imaging of Glioma: A Multiparametric Analysis
title_full	Effects of Carbidopa Premedication on <sup>18</sup>F-FDOPA PET Imaging of Glioma: A Multiparametric Analysis
title_fullStr	Effects of Carbidopa Premedication on <sup>18</sup>F-FDOPA PET Imaging of Glioma: A Multiparametric Analysis
title_full_unstemmed	Effects of Carbidopa Premedication on <sup>18</sup>F-FDOPA PET Imaging of Glioma: A Multiparametric Analysis
title_sort	effects of carbidopa premedication on <sup>18</sup>f-fdopa pet imaging of glioma: a multiparametric analysis
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/e5ef4850102e4b4e99bb04af7da0c816
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Effects of Carbidopa Premedication on <sup>18</sup>F-FDOPA PET Imaging of Glioma: A Multiparametric Analysis

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