CD36 inhibits β-catenin/c-myc-mediated glycolysis through ubiquitination of GPC4 to repress colorectal tumorigenesis

CD36 is a membrane glycoprotein that has been shown to have tumour promoting or suppressor function depending on tumour type. Here, the authors address CD36 function in colorectal cancer and show it acts as a tumour suppressor by inhibiting B-catenin/myc signalling, resulting in downregulation of gl...

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Autores principales:	Yuan Fang, Zhi-Yong Shen, Yi-Zhi Zhan, Xiao-Chuang Feng, Ke-Li Chen, Yong-Sheng Li, Hai-Jun Deng, Su-Ming Pan, De-Hua Wu, Yi Ding
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e5f4970ff08845f79624be8589add0e4
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spelling	oai:doaj.org-article:e5f4970ff08845f79624be8589add0e42021-12-02T15:35:17ZCD36 inhibits β-catenin/c-myc-mediated glycolysis through ubiquitination of GPC4 to repress colorectal tumorigenesis10.1038/s41467-019-11662-32041-1723https://doaj.org/article/e5f4970ff08845f79624be8589add0e42019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11662-3https://doaj.org/toc/2041-1723CD36 is a membrane glycoprotein that has been shown to have tumour promoting or suppressor function depending on tumour type. Here, the authors address CD36 function in colorectal cancer and show it acts as a tumour suppressor by inhibiting B-catenin/myc signalling, resulting in downregulation of glycolysis.Yuan FangZhi-Yong ShenYi-Zhi ZhanXiao-Chuang FengKe-Li ChenYong-Sheng LiHai-Jun DengSu-Ming PanDe-Hua WuYi DingNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yuan Fang Zhi-Yong Shen Yi-Zhi Zhan Xiao-Chuang Feng Ke-Li Chen Yong-Sheng Li Hai-Jun Deng Su-Ming Pan De-Hua Wu Yi Ding CD36 inhibits β-catenin/c-myc-mediated glycolysis through ubiquitination of GPC4 to repress colorectal tumorigenesis
description	CD36 is a membrane glycoprotein that has been shown to have tumour promoting or suppressor function depending on tumour type. Here, the authors address CD36 function in colorectal cancer and show it acts as a tumour suppressor by inhibiting B-catenin/myc signalling, resulting in downregulation of glycolysis.
format	article
author	Yuan Fang Zhi-Yong Shen Yi-Zhi Zhan Xiao-Chuang Feng Ke-Li Chen Yong-Sheng Li Hai-Jun Deng Su-Ming Pan De-Hua Wu Yi Ding
author_facet	Yuan Fang Zhi-Yong Shen Yi-Zhi Zhan Xiao-Chuang Feng Ke-Li Chen Yong-Sheng Li Hai-Jun Deng Su-Ming Pan De-Hua Wu Yi Ding
author_sort	Yuan Fang
title	CD36 inhibits β-catenin/c-myc-mediated glycolysis through ubiquitination of GPC4 to repress colorectal tumorigenesis
title_short	CD36 inhibits β-catenin/c-myc-mediated glycolysis through ubiquitination of GPC4 to repress colorectal tumorigenesis
title_full	CD36 inhibits β-catenin/c-myc-mediated glycolysis through ubiquitination of GPC4 to repress colorectal tumorigenesis
title_fullStr	CD36 inhibits β-catenin/c-myc-mediated glycolysis through ubiquitination of GPC4 to repress colorectal tumorigenesis
title_full_unstemmed	CD36 inhibits β-catenin/c-myc-mediated glycolysis through ubiquitination of GPC4 to repress colorectal tumorigenesis
title_sort	cd36 inhibits β-catenin/c-myc-mediated glycolysis through ubiquitination of gpc4 to repress colorectal tumorigenesis
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/e5f4970ff08845f79624be8589add0e4
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CD36 inhibits β-catenin/c-myc-mediated glycolysis through ubiquitination of GPC4 to repress colorectal tumorigenesis

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