Nature behavioral responses, lipid profile and state of cardiovascular system in lead intoxication modelling on the background of hyperlipidemia in albino rats

The article describes the comparative study of the effect of lead intoxication in healthy animals and in terms of modelled hyperlipidemic condition on lipid metabolism, ECG performance, behavior in the test of the extrapolation of deliverance. The study was performed on 40 albino outbred adult male...

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Autores principales:	N. L. Yakimova, V. A. Vokina
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2016
Materias:	lead hyperlipidemia electrocardiography behavior rats Science Q
Acceso en línea:	https://doaj.org/article/e5f8a4baa3bf46e5bae43e281df71371
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spelling	oai:doaj.org-article:e5f8a4baa3bf46e5bae43e281df713712021-11-23T06:14:36ZNature behavioral responses, lipid profile and state of cardiovascular system in lead intoxication modelling on the background of hyperlipidemia in albino rats2541-94202587-959610.12737/23410https://doaj.org/article/e5f8a4baa3bf46e5bae43e281df713712016-09-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/296https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596The article describes the comparative study of the effect of lead intoxication in healthy animals and in terms of modelled hyperlipidemic condition on lipid metabolism, ECG performance, behavior in the test of the extrapolation of deliverance. The study was performed on 40 albino outbred adult male rats. Modeling hyperlipidemic condition was carried out daily by feeding natural unsalted fat at the rate of 8 grams per animal for 16 days. Lead intoxication was created after the atherogenic diet by adding lead acetate into drinking water in a dose of 50 mg/kg of body weight for 4 weeks. To investigate the lipid metabolism was measured in serum total cholesterol, triglycerides, HDL cholesterol, LDL cholesterol. In the test of extrapolation deliverance 70 % of animals with lead intoxication on the lipid load background did not cope with the task versus 40 % of albino rats in the group with lead acetate exposure alone. All control animals successfully solved the problem of the deliverance test. The deterioration of the functioning of the cardiovascular system of rats with lead poisoning on the background of atherogenic diet was manifested by elongation of intraventricular conduction intervals on an electrocardiogram as compared with animals with lead intoxication alone. Disorders of lipid metabolism were manifested by increased levels of LDL cholesterol in rats with lead intoxication on the background of hyperlipidemia to 0.86 (0.69-1.14) mmol/l compared with the value of 0.67 (0.58-0.79) mmol/l in animals with lead intoxication.N. L. YakimovaV. A. VokinaScientific Сentre for Family Health and Human Reproduction ProblemsarticleleadhyperlipidemiaelectrocardiographybehaviorratsScienceQRUActa Biomedica Scientifica, Vol 1, Iss 5, Pp 138-141 (2016)
institution	DOAJ
collection	DOAJ
language	RU
topic	lead hyperlipidemia electrocardiography behavior rats Science Q
spellingShingle	lead hyperlipidemia electrocardiography behavior rats Science Q N. L. Yakimova V. A. Vokina Nature behavioral responses, lipid profile and state of cardiovascular system in lead intoxication modelling on the background of hyperlipidemia in albino rats
description	The article describes the comparative study of the effect of lead intoxication in healthy animals and in terms of modelled hyperlipidemic condition on lipid metabolism, ECG performance, behavior in the test of the extrapolation of deliverance. The study was performed on 40 albino outbred adult male rats. Modeling hyperlipidemic condition was carried out daily by feeding natural unsalted fat at the rate of 8 grams per animal for 16 days. Lead intoxication was created after the atherogenic diet by adding lead acetate into drinking water in a dose of 50 mg/kg of body weight for 4 weeks. To investigate the lipid metabolism was measured in serum total cholesterol, triglycerides, HDL cholesterol, LDL cholesterol. In the test of extrapolation deliverance 70 % of animals with lead intoxication on the lipid load background did not cope with the task versus 40 % of albino rats in the group with lead acetate exposure alone. All control animals successfully solved the problem of the deliverance test. The deterioration of the functioning of the cardiovascular system of rats with lead poisoning on the background of atherogenic diet was manifested by elongation of intraventricular conduction intervals on an electrocardiogram as compared with animals with lead intoxication alone. Disorders of lipid metabolism were manifested by increased levels of LDL cholesterol in rats with lead intoxication on the background of hyperlipidemia to 0.86 (0.69-1.14) mmol/l compared with the value of 0.67 (0.58-0.79) mmol/l in animals with lead intoxication.
format	article
author	N. L. Yakimova V. A. Vokina
author_facet	N. L. Yakimova V. A. Vokina
author_sort	N. L. Yakimova
title	Nature behavioral responses, lipid profile and state of cardiovascular system in lead intoxication modelling on the background of hyperlipidemia in albino rats
title_short	Nature behavioral responses, lipid profile and state of cardiovascular system in lead intoxication modelling on the background of hyperlipidemia in albino rats
title_full	Nature behavioral responses, lipid profile and state of cardiovascular system in lead intoxication modelling on the background of hyperlipidemia in albino rats
title_fullStr	Nature behavioral responses, lipid profile and state of cardiovascular system in lead intoxication modelling on the background of hyperlipidemia in albino rats
title_full_unstemmed	Nature behavioral responses, lipid profile and state of cardiovascular system in lead intoxication modelling on the background of hyperlipidemia in albino rats
title_sort	nature behavioral responses, lipid profile and state of cardiovascular system in lead intoxication modelling on the background of hyperlipidemia in albino rats
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2016
url	https://doaj.org/article/e5f8a4baa3bf46e5bae43e281df71371
work_keys_str_mv	AT nlyakimova naturebehavioralresponseslipidprofileandstateofcardiovascularsysteminleadintoxicationmodellingonthebackgroundofhyperlipidemiainalbinorats AT vavokina naturebehavioralresponseslipidprofileandstateofcardiovascularsysteminleadintoxicationmodellingonthebackgroundofhyperlipidemiainalbinorats
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Nature behavioral responses, lipid profile and state of cardiovascular system in lead intoxication modelling on the background of hyperlipidemia in albino rats

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