Six Autoimmune Disorders Are Associated With Increased Incidence of Gastric Cancer: A Systematic Review and Meta-Analysis of Half a Million Patients

BackgroundGastric cancer is one of the most common cancers worldwide, with a high mortality rate. The potential etiological role of autoimmune (AI) disorders has been described in gastric cancer; however, the literature is controversial. This study aims to provide a comprehensive summary of the asso...

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Autores principales:	Noémi Zádori, Lajos Szakó, Szilárd Váncsa, Nóra Vörhendi, Eduard Oštarijaš, Szabolcs Kiss, Levente Frim, Péter Hegyi, József Czimmer
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	: autoimmune disease gastric cancer autoimmunity risk standardized incidence rate Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/e5f9a479616541d199bec86b8eb9ff7e
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spelling	oai:doaj.org-article:e5f9a479616541d199bec86b8eb9ff7e2021-11-30T12:35:04ZSix Autoimmune Disorders Are Associated With Increased Incidence of Gastric Cancer: A Systematic Review and Meta-Analysis of Half a Million Patients1664-322410.3389/fimmu.2021.750533https://doaj.org/article/e5f9a479616541d199bec86b8eb9ff7e2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fimmu.2021.750533/fullhttps://doaj.org/toc/1664-3224BackgroundGastric cancer is one of the most common cancers worldwide, with a high mortality rate. The potential etiological role of autoimmune (AI) disorders has been described in gastric cancer; however, the literature is controversial. This study aims to provide a comprehensive summary of the association between autoimmune disorders and the incidence of gastric cancer.MethodsThis study was registered on PROSPERO under registration number CRD42021262875. The systematic literature search was conducted in four scientific databases up to May 17, 2021. Studies that reported standardized incidence rate (SIR) of gastric cancer in autoimmune disorders were eligible. We calculated pooled SIRs with 95% confidence intervals (CIs) in this meta-analysis.ResultsWe included 43 articles describing 36 AI disorders with data of 499,427 patients from four continents in our systematic review and meta-analysis. Significantly increased incidence of gastric cancer was observed in dermatomyositis (SIR = 3.71; CI: 2.04, 6.75), pernicious anemia (SIR = 3.28; CI: 2.71, 3.96), inflammatory myopathies (SIR = 2.68; CI:1.40; 5.12), systemic lupus erythematosus (SIR = 1.48; CI: 1.09, 2.01), diabetes mellitus type I (SIR = 1.29; CI:1.14, 1,47), and Graves’ disease (SIR = 1.28; CI: 1.16, 1.41). No significant associations could be found regarding other AI disorders.ConclusionsPernicious anemia, Graves’ disease, dermatomyositis, diabetes mellitus type I, inflammatory myopathies, and systemic lupus erythematosus are associated with higher incidence rates of gastric cancer. Therefore, close gastroenterological follow-up or routinely performed gastroscopy and application of other diagnostic measures may be cost-effective and clinically helpful for patients diagnosed with these autoimmune diseases.Noémi ZádoriNoémi ZádoriLajos SzakóLajos SzakóSzilárd VáncsaSzilárd VáncsaSzilárd VáncsaNóra VörhendiNóra VörhendiEduard OštarijašSzabolcs KissSzabolcs KissSzabolcs KissLevente FrimPéter HegyiPéter HegyiPéter HegyiPéter HegyiJózsef CzimmerJózsef CzimmerFrontiers Media S.A.article: autoimmune diseasegastric cancerautoimmunityriskstandardized incidence rateImmunologic diseases. AllergyRC581-607ENFrontiers in Immunology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	: autoimmune disease gastric cancer autoimmunity risk standardized incidence rate Immunologic diseases. Allergy RC581-607
spellingShingle	: autoimmune disease gastric cancer autoimmunity risk standardized incidence rate Immunologic diseases. Allergy RC581-607 Noémi Zádori Noémi Zádori Lajos Szakó Lajos Szakó Szilárd Váncsa Szilárd Váncsa Szilárd Váncsa Nóra Vörhendi Nóra Vörhendi Eduard Oštarijaš Szabolcs Kiss Szabolcs Kiss Szabolcs Kiss Levente Frim Péter Hegyi Péter Hegyi Péter Hegyi Péter Hegyi József Czimmer József Czimmer Six Autoimmune Disorders Are Associated With Increased Incidence of Gastric Cancer: A Systematic Review and Meta-Analysis of Half a Million Patients
description	BackgroundGastric cancer is one of the most common cancers worldwide, with a high mortality rate. The potential etiological role of autoimmune (AI) disorders has been described in gastric cancer; however, the literature is controversial. This study aims to provide a comprehensive summary of the association between autoimmune disorders and the incidence of gastric cancer.MethodsThis study was registered on PROSPERO under registration number CRD42021262875. The systematic literature search was conducted in four scientific databases up to May 17, 2021. Studies that reported standardized incidence rate (SIR) of gastric cancer in autoimmune disorders were eligible. We calculated pooled SIRs with 95% confidence intervals (CIs) in this meta-analysis.ResultsWe included 43 articles describing 36 AI disorders with data of 499,427 patients from four continents in our systematic review and meta-analysis. Significantly increased incidence of gastric cancer was observed in dermatomyositis (SIR = 3.71; CI: 2.04, 6.75), pernicious anemia (SIR = 3.28; CI: 2.71, 3.96), inflammatory myopathies (SIR = 2.68; CI:1.40; 5.12), systemic lupus erythematosus (SIR = 1.48; CI: 1.09, 2.01), diabetes mellitus type I (SIR = 1.29; CI:1.14, 1,47), and Graves’ disease (SIR = 1.28; CI: 1.16, 1.41). No significant associations could be found regarding other AI disorders.ConclusionsPernicious anemia, Graves’ disease, dermatomyositis, diabetes mellitus type I, inflammatory myopathies, and systemic lupus erythematosus are associated with higher incidence rates of gastric cancer. Therefore, close gastroenterological follow-up or routinely performed gastroscopy and application of other diagnostic measures may be cost-effective and clinically helpful for patients diagnosed with these autoimmune diseases.
format	article
author	Noémi Zádori Noémi Zádori Lajos Szakó Lajos Szakó Szilárd Váncsa Szilárd Váncsa Szilárd Váncsa Nóra Vörhendi Nóra Vörhendi Eduard Oštarijaš Szabolcs Kiss Szabolcs Kiss Szabolcs Kiss Levente Frim Péter Hegyi Péter Hegyi Péter Hegyi Péter Hegyi József Czimmer József Czimmer
author_facet	Noémi Zádori Noémi Zádori Lajos Szakó Lajos Szakó Szilárd Váncsa Szilárd Váncsa Szilárd Váncsa Nóra Vörhendi Nóra Vörhendi Eduard Oštarijaš Szabolcs Kiss Szabolcs Kiss Szabolcs Kiss Levente Frim Péter Hegyi Péter Hegyi Péter Hegyi Péter Hegyi József Czimmer József Czimmer
author_sort	Noémi Zádori
title	Six Autoimmune Disorders Are Associated With Increased Incidence of Gastric Cancer: A Systematic Review and Meta-Analysis of Half a Million Patients
title_short	Six Autoimmune Disorders Are Associated With Increased Incidence of Gastric Cancer: A Systematic Review and Meta-Analysis of Half a Million Patients
title_full	Six Autoimmune Disorders Are Associated With Increased Incidence of Gastric Cancer: A Systematic Review and Meta-Analysis of Half a Million Patients
title_fullStr	Six Autoimmune Disorders Are Associated With Increased Incidence of Gastric Cancer: A Systematic Review and Meta-Analysis of Half a Million Patients
title_full_unstemmed	Six Autoimmune Disorders Are Associated With Increased Incidence of Gastric Cancer: A Systematic Review and Meta-Analysis of Half a Million Patients
title_sort	six autoimmune disorders are associated with increased incidence of gastric cancer: a systematic review and meta-analysis of half a million patients
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/e5f9a479616541d199bec86b8eb9ff7e
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Six Autoimmune Disorders Are Associated With Increased Incidence of Gastric Cancer: A Systematic Review and Meta-Analysis of Half a Million Patients

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