Combining Mutations That Inhibit Two Distinct Steps of the ATP Hydrolysis Cycle Restores Wild-Type Function in the Lipopolysaccharide Transporter and Shows that ATP Binding Triggers Transport

Combining Mutations That Inhibit Two Distinct Steps of the ATP Hydrolysis Cycle Restores Wild-Type Function in the Lipopolysaccharide Transporter and Shows that ATP Binding Triggers Transport

ABSTRACT ATP-binding cassette (ABC) transporters constitute a large family of proteins present in all domains of life. They are powered by dynamic ATPases that harness energy from binding and hydrolyzing ATP through a cycle that involves the closing and reopening of their two ATP-binding domains. Th...

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Autores principales: Brent W. Simpson, Karanbir S. Pahil, Tristan W. Owens, Emily A. Lundstedt, Rebecca M. Davis, Daniel Kahne, Natividad Ruiz
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2019
Materias:
ABC transporters
ATPase
cell envelope
lipopolysaccharide
outer membrane
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/e5f9ae4be9c9430f83be36fa788bf4ff
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