Early pregnancy exposure to endocrine disrupting chemical mixtures are associated with inflammatory changes in maternal and neonatal circulation

Abstract Endocrine disrupting chemicals (EDCs) are ubiquitous, and pregnancy is a sensitive window for toxicant exposure. EDCs may disrupt the maternal immune system, which may lead to poor pregnancy outcomes. Most studies investigate single EDCs, even though “real life” exposures do not occur in is...

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Autores principales:	Angela S. Kelley, Margaret Banker, Jaclyn M. Goodrich, Dana C. Dolinoy, Charles Burant, Steven E. Domino, Yolanda R. Smith, Peter X. K. Song, Vasantha Padmanabhan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e5fd8099d17a4740828e323d66b8301d
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spelling	oai:doaj.org-article:e5fd8099d17a4740828e323d66b8301d2021-12-02T15:08:30ZEarly pregnancy exposure to endocrine disrupting chemical mixtures are associated with inflammatory changes in maternal and neonatal circulation10.1038/s41598-019-41134-z2045-2322https://doaj.org/article/e5fd8099d17a4740828e323d66b8301d2019-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-41134-zhttps://doaj.org/toc/2045-2322Abstract Endocrine disrupting chemicals (EDCs) are ubiquitous, and pregnancy is a sensitive window for toxicant exposure. EDCs may disrupt the maternal immune system, which may lead to poor pregnancy outcomes. Most studies investigate single EDCs, even though “real life” exposures do not occur in isolation. We tested the hypothesis that uniquely weighted mixtures of early pregnancy exposures are associated with distinct changes in the maternal and neonatal inflammasome. First trimester urine samples were tested for 12 phthalates, 12 phenols, and 17 metals in 56 women. Twelve cytokines were measured in first trimester and term maternal plasma, and in cord blood after delivery. Spearman correlations and linear regression were used to relate individual exposures with inflammatory cytokines. Linear regression was used to relate cytokine levels with gestational age and birth weight. Principal component analysis was used to assess the effect of weighted EDC mixtures on maternal and neonatal inflammation. Our results demonstrated that maternal and cord blood cytokines were differentially associated with (1) individual EDCs and (2) EDC mixtures. Several individual cytokines were positively associated with gestational age and birth weight. These observed associations between EDC mixtures and the pregnancy inflammasome may have clinical and public health implications for women of childbearing age.Angela S. KelleyMargaret BankerJaclyn M. GoodrichDana C. DolinoyCharles BurantSteven E. DominoYolanda R. SmithPeter X. K. SongVasantha PadmanabhanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Angela S. Kelley Margaret Banker Jaclyn M. Goodrich Dana C. Dolinoy Charles Burant Steven E. Domino Yolanda R. Smith Peter X. K. Song Vasantha Padmanabhan Early pregnancy exposure to endocrine disrupting chemical mixtures are associated with inflammatory changes in maternal and neonatal circulation
description	Abstract Endocrine disrupting chemicals (EDCs) are ubiquitous, and pregnancy is a sensitive window for toxicant exposure. EDCs may disrupt the maternal immune system, which may lead to poor pregnancy outcomes. Most studies investigate single EDCs, even though “real life” exposures do not occur in isolation. We tested the hypothesis that uniquely weighted mixtures of early pregnancy exposures are associated with distinct changes in the maternal and neonatal inflammasome. First trimester urine samples were tested for 12 phthalates, 12 phenols, and 17 metals in 56 women. Twelve cytokines were measured in first trimester and term maternal plasma, and in cord blood after delivery. Spearman correlations and linear regression were used to relate individual exposures with inflammatory cytokines. Linear regression was used to relate cytokine levels with gestational age and birth weight. Principal component analysis was used to assess the effect of weighted EDC mixtures on maternal and neonatal inflammation. Our results demonstrated that maternal and cord blood cytokines were differentially associated with (1) individual EDCs and (2) EDC mixtures. Several individual cytokines were positively associated with gestational age and birth weight. These observed associations between EDC mixtures and the pregnancy inflammasome may have clinical and public health implications for women of childbearing age.
format	article
author	Angela S. Kelley Margaret Banker Jaclyn M. Goodrich Dana C. Dolinoy Charles Burant Steven E. Domino Yolanda R. Smith Peter X. K. Song Vasantha Padmanabhan
author_facet	Angela S. Kelley Margaret Banker Jaclyn M. Goodrich Dana C. Dolinoy Charles Burant Steven E. Domino Yolanda R. Smith Peter X. K. Song Vasantha Padmanabhan
author_sort	Angela S. Kelley
title	Early pregnancy exposure to endocrine disrupting chemical mixtures are associated with inflammatory changes in maternal and neonatal circulation
title_short	Early pregnancy exposure to endocrine disrupting chemical mixtures are associated with inflammatory changes in maternal and neonatal circulation
title_full	Early pregnancy exposure to endocrine disrupting chemical mixtures are associated with inflammatory changes in maternal and neonatal circulation
title_fullStr	Early pregnancy exposure to endocrine disrupting chemical mixtures are associated with inflammatory changes in maternal and neonatal circulation
title_full_unstemmed	Early pregnancy exposure to endocrine disrupting chemical mixtures are associated with inflammatory changes in maternal and neonatal circulation
title_sort	early pregnancy exposure to endocrine disrupting chemical mixtures are associated with inflammatory changes in maternal and neonatal circulation
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/e5fd8099d17a4740828e323d66b8301d
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Early pregnancy exposure to endocrine disrupting chemical mixtures are associated with inflammatory changes in maternal and neonatal circulation

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