Administration of cardiac mesenchymal cells modulates innate immunity in the acute phase of myocardial infarction in mice

Abstract Although cardiac mesenchymal cell (CMC) therapy mitigates post-infarct cardiac dysfunction, the underlying mechanisms remain unidentified. It is acknowledged that donor cells are neither appreciably retained nor meaningfully contribute to tissue regeneration—suggesting a paracrine-mediated...

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Autores principales:	Yi Kang, Marjan Nasr, Yiru Guo, Shizuka Uchida, Tyler Weirick, Hong Li, Jae Kim, Joseph B. Moore, Senthilkumar Muthusamy, Roberto Bolli, Marcin Wysoczynski
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e60037ebf1604f059252e71ae039ca99
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spelling	oai:doaj.org-article:e60037ebf1604f059252e71ae039ca992021-12-02T19:12:28ZAdministration of cardiac mesenchymal cells modulates innate immunity in the acute phase of myocardial infarction in mice10.1038/s41598-020-71580-z2045-2322https://doaj.org/article/e60037ebf1604f059252e71ae039ca992020-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-71580-zhttps://doaj.org/toc/2045-2322Abstract Although cardiac mesenchymal cell (CMC) therapy mitigates post-infarct cardiac dysfunction, the underlying mechanisms remain unidentified. It is acknowledged that donor cells are neither appreciably retained nor meaningfully contribute to tissue regeneration—suggesting a paracrine-mediated mechanism of action. As the immune system is inextricably linked to wound healing/remodeling in the ischemically injured heart, the reparative actions of CMCs may be attributed to their immunoregulatory properties. The current study evaluated the consequences of CMC administration on post myocardial infarction (MI) immune responses in vivo and paracrine-mediated immune cell function in vitro. CMC administration preferentially elicited the recruitment of cell types associated with innate immunity (e.g., monocytes/macrophages and neutrophils). CMC paracrine signaling assays revealed enhancement in innate immune cell chemoattraction, survival, and phagocytosis, and diminished pro-inflammatory immune cell activation; data that identifies and catalogues fundamental immunomodulatory properties of CMCs, which have broad implications regarding the mechanism of action of CMCs in cardiac repair.Yi KangMarjan NasrYiru GuoShizuka UchidaTyler WeirickHong LiJae KimJoseph B. MooreSenthilkumar MuthusamyRoberto BolliMarcin WysoczynskiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yi Kang Marjan Nasr Yiru Guo Shizuka Uchida Tyler Weirick Hong Li Jae Kim Joseph B. Moore Senthilkumar Muthusamy Roberto Bolli Marcin Wysoczynski Administration of cardiac mesenchymal cells modulates innate immunity in the acute phase of myocardial infarction in mice
description	Abstract Although cardiac mesenchymal cell (CMC) therapy mitigates post-infarct cardiac dysfunction, the underlying mechanisms remain unidentified. It is acknowledged that donor cells are neither appreciably retained nor meaningfully contribute to tissue regeneration—suggesting a paracrine-mediated mechanism of action. As the immune system is inextricably linked to wound healing/remodeling in the ischemically injured heart, the reparative actions of CMCs may be attributed to their immunoregulatory properties. The current study evaluated the consequences of CMC administration on post myocardial infarction (MI) immune responses in vivo and paracrine-mediated immune cell function in vitro. CMC administration preferentially elicited the recruitment of cell types associated with innate immunity (e.g., monocytes/macrophages and neutrophils). CMC paracrine signaling assays revealed enhancement in innate immune cell chemoattraction, survival, and phagocytosis, and diminished pro-inflammatory immune cell activation; data that identifies and catalogues fundamental immunomodulatory properties of CMCs, which have broad implications regarding the mechanism of action of CMCs in cardiac repair.
format	article
author	Yi Kang Marjan Nasr Yiru Guo Shizuka Uchida Tyler Weirick Hong Li Jae Kim Joseph B. Moore Senthilkumar Muthusamy Roberto Bolli Marcin Wysoczynski
author_facet	Yi Kang Marjan Nasr Yiru Guo Shizuka Uchida Tyler Weirick Hong Li Jae Kim Joseph B. Moore Senthilkumar Muthusamy Roberto Bolli Marcin Wysoczynski
author_sort	Yi Kang
title	Administration of cardiac mesenchymal cells modulates innate immunity in the acute phase of myocardial infarction in mice
title_short	Administration of cardiac mesenchymal cells modulates innate immunity in the acute phase of myocardial infarction in mice
title_full	Administration of cardiac mesenchymal cells modulates innate immunity in the acute phase of myocardial infarction in mice
title_fullStr	Administration of cardiac mesenchymal cells modulates innate immunity in the acute phase of myocardial infarction in mice
title_full_unstemmed	Administration of cardiac mesenchymal cells modulates innate immunity in the acute phase of myocardial infarction in mice
title_sort	administration of cardiac mesenchymal cells modulates innate immunity in the acute phase of myocardial infarction in mice
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/e60037ebf1604f059252e71ae039ca99
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Administration of cardiac mesenchymal cells modulates innate immunity in the acute phase of myocardial infarction in mice

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