Usp9x regulates Ets-1 ubiquitination and stability to control NRAS expression and tumorigenicity in melanoma

Usp9x is a deubiquitinating enzyme with altered expression in melanoma; however its functional contribution in this context is not clear. Here the authors show that Usp9x regulates the stability of the transcription factor Ets-1 that in turn impacts metastatic melanoma through increased expression o...

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Autores principales:	Harish Potu, Luke F. Peterson, Malathi Kandarpa, Anupama Pal, Hanshi Sun, Alison Durham, Paul W. Harms, Peter C. Hollenhorst, Ugur Eskiocak, Moshe Talpaz, Nicholas J. Donato
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e602171c7095415dab7480a2914dff72
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spelling	oai:doaj.org-article:e602171c7095415dab7480a2914dff722021-12-02T17:06:06ZUsp9x regulates Ets-1 ubiquitination and stability to control NRAS expression and tumorigenicity in melanoma10.1038/ncomms144492041-1723https://doaj.org/article/e602171c7095415dab7480a2914dff722017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14449https://doaj.org/toc/2041-1723Usp9x is a deubiquitinating enzyme with altered expression in melanoma; however its functional contribution in this context is not clear. Here the authors show that Usp9x regulates the stability of the transcription factor Ets-1 that in turn impacts metastatic melanoma through increased expression of NRAS.Harish PotuLuke F. PetersonMalathi KandarpaAnupama PalHanshi SunAlison DurhamPaul W. HarmsPeter C. HollenhorstUgur EskiocakMoshe TalpazNicholas J. DonatoNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Harish Potu Luke F. Peterson Malathi Kandarpa Anupama Pal Hanshi Sun Alison Durham Paul W. Harms Peter C. Hollenhorst Ugur Eskiocak Moshe Talpaz Nicholas J. Donato Usp9x regulates Ets-1 ubiquitination and stability to control NRAS expression and tumorigenicity in melanoma
description	Usp9x is a deubiquitinating enzyme with altered expression in melanoma; however its functional contribution in this context is not clear. Here the authors show that Usp9x regulates the stability of the transcription factor Ets-1 that in turn impacts metastatic melanoma through increased expression of NRAS.
format	article
author	Harish Potu Luke F. Peterson Malathi Kandarpa Anupama Pal Hanshi Sun Alison Durham Paul W. Harms Peter C. Hollenhorst Ugur Eskiocak Moshe Talpaz Nicholas J. Donato
author_facet	Harish Potu Luke F. Peterson Malathi Kandarpa Anupama Pal Hanshi Sun Alison Durham Paul W. Harms Peter C. Hollenhorst Ugur Eskiocak Moshe Talpaz Nicholas J. Donato
author_sort	Harish Potu
title	Usp9x regulates Ets-1 ubiquitination and stability to control NRAS expression and tumorigenicity in melanoma
title_short	Usp9x regulates Ets-1 ubiquitination and stability to control NRAS expression and tumorigenicity in melanoma
title_full	Usp9x regulates Ets-1 ubiquitination and stability to control NRAS expression and tumorigenicity in melanoma
title_fullStr	Usp9x regulates Ets-1 ubiquitination and stability to control NRAS expression and tumorigenicity in melanoma
title_full_unstemmed	Usp9x regulates Ets-1 ubiquitination and stability to control NRAS expression and tumorigenicity in melanoma
title_sort	usp9x regulates ets-1 ubiquitination and stability to control nras expression and tumorigenicity in melanoma
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/e602171c7095415dab7480a2914dff72
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Usp9x regulates Ets-1 ubiquitination and stability to control NRAS expression and tumorigenicity in melanoma

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