Baclofen for narcolepsy with cataplexy: two cases

Elliott Kyung Lee,1,2 Alan Bruce Douglass1,2 1Department of Psychiatry, Faculty of Medicine, Institute of Mental Health Research, University of Ottawa, 2Royal Ottawa Mental Health Center, Ottawa, ON, Canada Abstract: Narcolepsy is a disabling sleep disorder characterized by daytime hypersomnolence....

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Autores principales:	Lee EK, Douglass AB
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495
Acceso en línea:	https://doaj.org/article/e60548a9c2174708ab410a22336759ea
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spelling	oai:doaj.org-article:e60548a9c2174708ab410a22336759ea2021-12-02T00:48:08ZBaclofen for narcolepsy with cataplexy: two cases1179-1608https://doaj.org/article/e60548a9c2174708ab410a22336759ea2015-07-01T00:00:00Zhttp://www.dovepress.com/baclofen-for-narcolepsy-with-cataplexy-two-cases-peer-reviewed-article-NSShttps://doaj.org/toc/1179-1608Elliott Kyung Lee,1,2 Alan Bruce Douglass1,2 1Department of Psychiatry, Faculty of Medicine, Institute of Mental Health Research, University of Ottawa, 2Royal Ottawa Mental Health Center, Ottawa, ON, Canada Abstract: Narcolepsy is a disabling sleep disorder characterized by daytime hypersomnolence. Those with cataplexy have spells of muscle weakness precipitated by strong emotions, especially laughter or surprise. Cataplexy treatments include antidepressants or a GABA-B agonist, gamma hydroxybutyrate (GHB). GHB is the most effective treatment for cataplexy, but is expensive and can have significant side effects. A recent report of a murine model of narcolepsy-cataplexy suggests R-baclofen has potential efficacy against cataplexy. We report on two narcolepsy patients with multiple daily cataplexy episodes, one of whom had been effectively treated with GHB, but had to discontinue it for unrelated medical reasons. Both subsequently tried baclofen and experienced almost complete resolution of cataplexy. This report suggests baclofen can be an effective treatment for cataplexy in humans and warrants further study. Keywords: hypersomnolence, gamma hydroxybutyrate, excessive daytime sleepinessLee EKDouglass ABDove Medical PressarticlePsychiatryRC435-571Neurophysiology and neuropsychologyQP351-495ENNature and Science of Sleep, Vol 2015, Iss default, Pp 81-83 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495
spellingShingle	Psychiatry RC435-571 Neurophysiology and neuropsychology QP351-495 Lee EK Douglass AB Baclofen for narcolepsy with cataplexy: two cases
description	Elliott Kyung Lee,1,2 Alan Bruce Douglass1,2 1Department of Psychiatry, Faculty of Medicine, Institute of Mental Health Research, University of Ottawa, 2Royal Ottawa Mental Health Center, Ottawa, ON, Canada Abstract: Narcolepsy is a disabling sleep disorder characterized by daytime hypersomnolence. Those with cataplexy have spells of muscle weakness precipitated by strong emotions, especially laughter or surprise. Cataplexy treatments include antidepressants or a GABA-B agonist, gamma hydroxybutyrate (GHB). GHB is the most effective treatment for cataplexy, but is expensive and can have significant side effects. A recent report of a murine model of narcolepsy-cataplexy suggests R-baclofen has potential efficacy against cataplexy. We report on two narcolepsy patients with multiple daily cataplexy episodes, one of whom had been effectively treated with GHB, but had to discontinue it for unrelated medical reasons. Both subsequently tried baclofen and experienced almost complete resolution of cataplexy. This report suggests baclofen can be an effective treatment for cataplexy in humans and warrants further study. Keywords: hypersomnolence, gamma hydroxybutyrate, excessive daytime sleepiness
format	article
author	Lee EK Douglass AB
author_facet	Lee EK Douglass AB
author_sort	Lee EK
title	Baclofen for narcolepsy with cataplexy: two cases
title_short	Baclofen for narcolepsy with cataplexy: two cases
title_full	Baclofen for narcolepsy with cataplexy: two cases
title_fullStr	Baclofen for narcolepsy with cataplexy: two cases
title_full_unstemmed	Baclofen for narcolepsy with cataplexy: two cases
title_sort	baclofen for narcolepsy with cataplexy: two cases
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/e60548a9c2174708ab410a22336759ea
work_keys_str_mv	AT leeek baclofenfornarcolepsywithcataplexytwocases AT douglassab baclofenfornarcolepsywithcataplexytwocases
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Baclofen for narcolepsy with cataplexy: two cases

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