Tendon healing is adversely affected by low-grade inflammation

Abstract Background Tendinopathy is common, presents with pain and activity limitation, and is associated with a high risk of recurrence of the injury. Tendinopathy usually occurs as a results of a disrupted healing response to a primary injury where cellular and molecular pathways lead to low grade...

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Autores principales:	Emanuele Chisari, Laura Rehak, Wasim S. Khan, Nicola Maffulli
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Inflammation Tendinopathy Healing Proinflammatory cytokines Orthopedic surgery RD701-811 Diseases of the musculoskeletal system RC925-935
Acceso en línea:	https://doaj.org/article/e60605ef6a744155ad63610853e399bb
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spelling	oai:doaj.org-article:e60605ef6a744155ad63610853e399bb2021-12-05T12:19:19ZTendon healing is adversely affected by low-grade inflammation10.1186/s13018-021-02811-w1749-799Xhttps://doaj.org/article/e60605ef6a744155ad63610853e399bb2021-12-01T00:00:00Zhttps://doi.org/10.1186/s13018-021-02811-whttps://doaj.org/toc/1749-799XAbstract Background Tendinopathy is common, presents with pain and activity limitation, and is associated with a high risk of recurrence of the injury. Tendinopathy usually occurs as a results of a disrupted healing response to a primary injury where cellular and molecular pathways lead to low grade chronic inflammation. Main findings There has been a renewed interest in investigating the role of Inflammation in the pathogenesis of tendinopathy, in particular during the initial phases of the condition where it may not be clinically evident. Understanding the early and late stages of tendon injury pathogenesis would help develop new and effective treatments addressed at targeting the inflammatory pathways. Conclusion This review outlines the role of low-grade Inflammation in the pathogenesis of tendinopathy, stressing the role of proinflammatory cytokines, proteolytic enzymes and growth factors, and explores how Inflammation exerts a negative influence on the process of tendon healing.Emanuele ChisariLaura RehakWasim S. KhanNicola MaffulliBMCarticleInflammationTendinopathyHealingProinflammatory cytokinesOrthopedic surgeryRD701-811Diseases of the musculoskeletal systemRC925-935ENJournal of Orthopaedic Surgery and Research, Vol 16, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Inflammation Tendinopathy Healing Proinflammatory cytokines Orthopedic surgery RD701-811 Diseases of the musculoskeletal system RC925-935
spellingShingle	Inflammation Tendinopathy Healing Proinflammatory cytokines Orthopedic surgery RD701-811 Diseases of the musculoskeletal system RC925-935 Emanuele Chisari Laura Rehak Wasim S. Khan Nicola Maffulli Tendon healing is adversely affected by low-grade inflammation
description	Abstract Background Tendinopathy is common, presents with pain and activity limitation, and is associated with a high risk of recurrence of the injury. Tendinopathy usually occurs as a results of a disrupted healing response to a primary injury where cellular and molecular pathways lead to low grade chronic inflammation. Main findings There has been a renewed interest in investigating the role of Inflammation in the pathogenesis of tendinopathy, in particular during the initial phases of the condition where it may not be clinically evident. Understanding the early and late stages of tendon injury pathogenesis would help develop new and effective treatments addressed at targeting the inflammatory pathways. Conclusion This review outlines the role of low-grade Inflammation in the pathogenesis of tendinopathy, stressing the role of proinflammatory cytokines, proteolytic enzymes and growth factors, and explores how Inflammation exerts a negative influence on the process of tendon healing.
format	article
author	Emanuele Chisari Laura Rehak Wasim S. Khan Nicola Maffulli
author_facet	Emanuele Chisari Laura Rehak Wasim S. Khan Nicola Maffulli
author_sort	Emanuele Chisari
title	Tendon healing is adversely affected by low-grade inflammation
title_short	Tendon healing is adversely affected by low-grade inflammation
title_full	Tendon healing is adversely affected by low-grade inflammation
title_fullStr	Tendon healing is adversely affected by low-grade inflammation
title_full_unstemmed	Tendon healing is adversely affected by low-grade inflammation
title_sort	tendon healing is adversely affected by low-grade inflammation
publisher	BMC
publishDate	2021
url	https://doaj.org/article/e60605ef6a744155ad63610853e399bb
work_keys_str_mv	AT emanuelechisari tendonhealingisadverselyaffectedbylowgradeinflammation AT laurarehak tendonhealingisadverselyaffectedbylowgradeinflammation AT wasimskhan tendonhealingisadverselyaffectedbylowgradeinflammation AT nicolamaffulli tendonhealingisadverselyaffectedbylowgradeinflammation
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Tendon healing is adversely affected by low-grade inflammation

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