Pathogenesis of the initial stages of severe COVID-19

Since SARS-CoV-2 first appeared in humans, the scientific community has tried to gather as much information as possible in order to find effective strategies for the containment and treatment this pandemic coronavirus. We reviewed the current published literature on SARS-CoV-2 with an emphasis on th...

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Autores principales:	Alexander S. Golota, Tatyana A. Kamilova, Olga V. Shneider, Dmitry A. Vologzhanin, Sergey G. Sherbak
Formato:	article
Lenguaje:	RU
Publicado:	Eco-vector 2021
Materias:	covid-19 coronavirus sars-cov-2 ace2 receptor antiviral immunity covid-19 pathogenesis Medicine R
Acceso en línea:	https://doaj.org/article/e606fb87488d477d9dce43f4fa467264
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spelling	oai:doaj.org-article:e606fb87488d477d9dce43f4fa4672642021-11-30T18:15:21ZPathogenesis of the initial stages of severe COVID-192220-30952618-862710.17816/clinpract71351https://doaj.org/article/e606fb87488d477d9dce43f4fa4672642021-07-01T00:00:00Zhttps://journals.eco-vector.com/clinpractice/article/viewFile/71351/pdfhttps://doaj.org/toc/2220-3095https://doaj.org/toc/2618-8627Since SARS-CoV-2 first appeared in humans, the scientific community has tried to gather as much information as possible in order to find effective strategies for the containment and treatment this pandemic coronavirus. We reviewed the current published literature on SARS-CoV-2 with an emphasis on the distribution of SARS-CoV-2 in tissues and body fluids, as well as data on the expression of its input receptors on the cell surface. COVID-19 affects many organ systems in many ways. These varied manifestations are associated with viral tropism and immune responses of the infected person, but the exact mechanisms are not yet fully understood. We emphasize the broad organotropism of SARS-CoV-2, as many studies have identified viral components (RNA, proteins) in many organs, including immune cells, pharynx, trachea, lungs, blood, heart, blood vessels, intestines, brain, kidneys, and male reproductive organs. Viral components are present in various body fluids, such as mucus, saliva, urine, cerebrospinal fluid, semen and breast milk. The main SARS-CoV-2 receptor, ACE2, is expressed at different levels in many tissues throughout the human body, but its expression levels do not always correspond to the detection of SARS-CoV-2, indicating a complex interaction between the virus and humans. We also highlight the role of the renin-angiotensin aldosterone system and its inhibitors in the context of COVID-19. In addition, SARS-CoV-2 has various strategies that are widely used in various tissues to evade innate antiviral immunity. Targeting immune evasion mediators of the virus can block its replication in COVID-19 patients. Together, these data shed light on the current understanding of the pathogenesis of SARS-CoV-2 and lay the groundwork for better diagnosis and treatment of patients with COVID-19.Alexander S. GolotaTatyana A. KamilovaOlga V. ShneiderDmitry A. VologzhaninSergey G. SherbakEco-vectorarticlecovid-19coronavirussars-cov-2ace2 receptorantiviral immunitycovid-19 pathogenesisMedicineRRUКлиническая практика , Vol 12, Iss 2, Pp 83-102 (2021)
institution	DOAJ
collection	DOAJ
language	RU
topic	covid-19 coronavirus sars-cov-2 ace2 receptor antiviral immunity covid-19 pathogenesis Medicine R
spellingShingle	covid-19 coronavirus sars-cov-2 ace2 receptor antiviral immunity covid-19 pathogenesis Medicine R Alexander S. Golota Tatyana A. Kamilova Olga V. Shneider Dmitry A. Vologzhanin Sergey G. Sherbak Pathogenesis of the initial stages of severe COVID-19
description	Since SARS-CoV-2 first appeared in humans, the scientific community has tried to gather as much information as possible in order to find effective strategies for the containment and treatment this pandemic coronavirus. We reviewed the current published literature on SARS-CoV-2 with an emphasis on the distribution of SARS-CoV-2 in tissues and body fluids, as well as data on the expression of its input receptors on the cell surface. COVID-19 affects many organ systems in many ways. These varied manifestations are associated with viral tropism and immune responses of the infected person, but the exact mechanisms are not yet fully understood. We emphasize the broad organotropism of SARS-CoV-2, as many studies have identified viral components (RNA, proteins) in many organs, including immune cells, pharynx, trachea, lungs, blood, heart, blood vessels, intestines, brain, kidneys, and male reproductive organs. Viral components are present in various body fluids, such as mucus, saliva, urine, cerebrospinal fluid, semen and breast milk. The main SARS-CoV-2 receptor, ACE2, is expressed at different levels in many tissues throughout the human body, but its expression levels do not always correspond to the detection of SARS-CoV-2, indicating a complex interaction between the virus and humans. We also highlight the role of the renin-angiotensin aldosterone system and its inhibitors in the context of COVID-19. In addition, SARS-CoV-2 has various strategies that are widely used in various tissues to evade innate antiviral immunity. Targeting immune evasion mediators of the virus can block its replication in COVID-19 patients. Together, these data shed light on the current understanding of the pathogenesis of SARS-CoV-2 and lay the groundwork for better diagnosis and treatment of patients with COVID-19.
format	article
author	Alexander S. Golota Tatyana A. Kamilova Olga V. Shneider Dmitry A. Vologzhanin Sergey G. Sherbak
author_facet	Alexander S. Golota Tatyana A. Kamilova Olga V. Shneider Dmitry A. Vologzhanin Sergey G. Sherbak
author_sort	Alexander S. Golota
title	Pathogenesis of the initial stages of severe COVID-19
title_short	Pathogenesis of the initial stages of severe COVID-19
title_full	Pathogenesis of the initial stages of severe COVID-19
title_fullStr	Pathogenesis of the initial stages of severe COVID-19
title_full_unstemmed	Pathogenesis of the initial stages of severe COVID-19
title_sort	pathogenesis of the initial stages of severe covid-19
publisher	Eco-vector
publishDate	2021
url	https://doaj.org/article/e606fb87488d477d9dce43f4fa467264
work_keys_str_mv	AT alexandersgolota pathogenesisoftheinitialstagesofseverecovid19 AT tatyanaakamilova pathogenesisoftheinitialstagesofseverecovid19 AT olgavshneider pathogenesisoftheinitialstagesofseverecovid19 AT dmitryavologzhanin pathogenesisoftheinitialstagesofseverecovid19 AT sergeygsherbak pathogenesisoftheinitialstagesofseverecovid19
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Pathogenesis of the initial stages of severe COVID-19

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