A covalent PIN1 inhibitor selectively targets cancer cells by a dual mechanism of action
PIN1 is a promising therapeutic target for cancer treatment. In this study, the authors identify a covalent inhibitor of PIN1 with anti-tumour and anti-metastatic properties thanks to PIN1 inactivation and to the release, after binding to PIN1, of a quinone-mimicking compound that elicits reactive o...
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Nature Portfolio
2017
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| Acceso en línea: | https://doaj.org/article/e607d20382804710bdbe82d915bc8ddd |
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oai:doaj.org-article:e607d20382804710bdbe82d915bc8ddd2021-12-02T17:06:16ZA covalent PIN1 inhibitor selectively targets cancer cells by a dual mechanism of action10.1038/ncomms157722041-1723https://doaj.org/article/e607d20382804710bdbe82d915bc8ddd2017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15772https://doaj.org/toc/2041-1723PIN1 is a promising therapeutic target for cancer treatment. In this study, the authors identify a covalent inhibitor of PIN1 with anti-tumour and anti-metastatic properties thanks to PIN1 inactivation and to the release, after binding to PIN1, of a quinone-mimicking compound that elicits reactive oxygen generation and causes DNA damage.Elena CampanerAlessandra RustighiAlessandro ZanniniAlberto CristianiSilvano PiazzaYari CianiOri KalidGali GolanErkan BalogluSharon ShachamBarbara ValsasinaUlisse CucchiAgnese Chiara PippioneMarco Lucio LolliBarbara GiabbaiPaola StoriciPaolo CarloniGiulia RossettiFederica BenvenutiEzia BelloMaurizio D’IncalciElisa CappuzzelloAntonio RosatoGiannino Del SalNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-15 (2017) |
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DOAJ |
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EN |
| topic |
Science Q |
| spellingShingle |
Science Q Elena Campaner Alessandra Rustighi Alessandro Zannini Alberto Cristiani Silvano Piazza Yari Ciani Ori Kalid Gali Golan Erkan Baloglu Sharon Shacham Barbara Valsasina Ulisse Cucchi Agnese Chiara Pippione Marco Lucio Lolli Barbara Giabbai Paola Storici Paolo Carloni Giulia Rossetti Federica Benvenuti Ezia Bello Maurizio D’Incalci Elisa Cappuzzello Antonio Rosato Giannino Del Sal A covalent PIN1 inhibitor selectively targets cancer cells by a dual mechanism of action |
| description |
PIN1 is a promising therapeutic target for cancer treatment. In this study, the authors identify a covalent inhibitor of PIN1 with anti-tumour and anti-metastatic properties thanks to PIN1 inactivation and to the release, after binding to PIN1, of a quinone-mimicking compound that elicits reactive oxygen generation and causes DNA damage. |
| format |
article |
| author |
Elena Campaner Alessandra Rustighi Alessandro Zannini Alberto Cristiani Silvano Piazza Yari Ciani Ori Kalid Gali Golan Erkan Baloglu Sharon Shacham Barbara Valsasina Ulisse Cucchi Agnese Chiara Pippione Marco Lucio Lolli Barbara Giabbai Paola Storici Paolo Carloni Giulia Rossetti Federica Benvenuti Ezia Bello Maurizio D’Incalci Elisa Cappuzzello Antonio Rosato Giannino Del Sal |
| author_facet |
Elena Campaner Alessandra Rustighi Alessandro Zannini Alberto Cristiani Silvano Piazza Yari Ciani Ori Kalid Gali Golan Erkan Baloglu Sharon Shacham Barbara Valsasina Ulisse Cucchi Agnese Chiara Pippione Marco Lucio Lolli Barbara Giabbai Paola Storici Paolo Carloni Giulia Rossetti Federica Benvenuti Ezia Bello Maurizio D’Incalci Elisa Cappuzzello Antonio Rosato Giannino Del Sal |
| author_sort |
Elena Campaner |
| title |
A covalent PIN1 inhibitor selectively targets cancer cells by a dual mechanism of action |
| title_short |
A covalent PIN1 inhibitor selectively targets cancer cells by a dual mechanism of action |
| title_full |
A covalent PIN1 inhibitor selectively targets cancer cells by a dual mechanism of action |
| title_fullStr |
A covalent PIN1 inhibitor selectively targets cancer cells by a dual mechanism of action |
| title_full_unstemmed |
A covalent PIN1 inhibitor selectively targets cancer cells by a dual mechanism of action |
| title_sort |
covalent pin1 inhibitor selectively targets cancer cells by a dual mechanism of action |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/e607d20382804710bdbe82d915bc8ddd |
| work_keys_str_mv |
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| _version_ |
1718381705932308480 |