Real world evidence of calcifediol or vitamin D prescription and mortality rate of COVID-19 in a retrospective cohort of hospitalized Andalusian patients
Abstract COVID-19 is a major worldwide health problem because of acute respiratory distress syndrome, and mortality. Several lines of evidence have suggested a relationship between the vitamin D endocrine system and severity of COVID-19. We present a survival study on a retrospective cohort of 15,96...
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2021
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oai:doaj.org-article:e60b0cec7d2a476690fdd391287063272021-12-05T12:13:57ZReal world evidence of calcifediol or vitamin D prescription and mortality rate of COVID-19 in a retrospective cohort of hospitalized Andalusian patients10.1038/s41598-021-02701-52045-2322https://doaj.org/article/e60b0cec7d2a476690fdd391287063272021-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-02701-5https://doaj.org/toc/2045-2322Abstract COVID-19 is a major worldwide health problem because of acute respiratory distress syndrome, and mortality. Several lines of evidence have suggested a relationship between the vitamin D endocrine system and severity of COVID-19. We present a survival study on a retrospective cohort of 15,968 patients, comprising all COVID-19 patients hospitalized in Andalusia between January and November 2020. Based on a central registry of electronic health records (the Andalusian Population Health Database, BPS), prescription of vitamin D or its metabolites within 15–30 days before hospitalization were recorded. The effect of prescription of vitamin D (metabolites) for other indication previous to the hospitalization was studied with respect to patient survival. Kaplan–Meier survival curves and hazard ratios support an association between prescription of these metabolites and patient survival. Such association was stronger for calcifediol (Hazard Ratio, HR = 0.67, with 95% confidence interval, CI, of [0.50–0.91]) than for cholecalciferol (HR = 0.75, with 95% CI of [0.61–0.91]), when prescribed 15 days prior hospitalization. Although the relation is maintained, there is a general decrease of this effect when a longer period of 30 days prior hospitalization is considered (calcifediol HR = 0.73, with 95% CI [0.57–0.95] and cholecalciferol HR = 0.88, with 95% CI [0.75, 1.03]), suggesting that association was stronger when the prescription was closer to the hospitalization.Carlos LouceraMaría Peña-ChiletMarina Esteban-MedinaDolores Muñoyerro-MuñizRomán VillegasJose Lopez-MirandaJesus Rodriguez-BañoIsaac TúnezRoger BouillonJoaquin DopazoJose Manuel Quesada GomezNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021) |
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Medicine R Science Q Carlos Loucera María Peña-Chilet Marina Esteban-Medina Dolores Muñoyerro-Muñiz Román Villegas Jose Lopez-Miranda Jesus Rodriguez-Baño Isaac Túnez Roger Bouillon Joaquin Dopazo Jose Manuel Quesada Gomez Real world evidence of calcifediol or vitamin D prescription and mortality rate of COVID-19 in a retrospective cohort of hospitalized Andalusian patients |
| description |
Abstract COVID-19 is a major worldwide health problem because of acute respiratory distress syndrome, and mortality. Several lines of evidence have suggested a relationship between the vitamin D endocrine system and severity of COVID-19. We present a survival study on a retrospective cohort of 15,968 patients, comprising all COVID-19 patients hospitalized in Andalusia between January and November 2020. Based on a central registry of electronic health records (the Andalusian Population Health Database, BPS), prescription of vitamin D or its metabolites within 15–30 days before hospitalization were recorded. The effect of prescription of vitamin D (metabolites) for other indication previous to the hospitalization was studied with respect to patient survival. Kaplan–Meier survival curves and hazard ratios support an association between prescription of these metabolites and patient survival. Such association was stronger for calcifediol (Hazard Ratio, HR = 0.67, with 95% confidence interval, CI, of [0.50–0.91]) than for cholecalciferol (HR = 0.75, with 95% CI of [0.61–0.91]), when prescribed 15 days prior hospitalization. Although the relation is maintained, there is a general decrease of this effect when a longer period of 30 days prior hospitalization is considered (calcifediol HR = 0.73, with 95% CI [0.57–0.95] and cholecalciferol HR = 0.88, with 95% CI [0.75, 1.03]), suggesting that association was stronger when the prescription was closer to the hospitalization. |
| format |
article |
| author |
Carlos Loucera María Peña-Chilet Marina Esteban-Medina Dolores Muñoyerro-Muñiz Román Villegas Jose Lopez-Miranda Jesus Rodriguez-Baño Isaac Túnez Roger Bouillon Joaquin Dopazo Jose Manuel Quesada Gomez |
| author_facet |
Carlos Loucera María Peña-Chilet Marina Esteban-Medina Dolores Muñoyerro-Muñiz Román Villegas Jose Lopez-Miranda Jesus Rodriguez-Baño Isaac Túnez Roger Bouillon Joaquin Dopazo Jose Manuel Quesada Gomez |
| author_sort |
Carlos Loucera |
| title |
Real world evidence of calcifediol or vitamin D prescription and mortality rate of COVID-19 in a retrospective cohort of hospitalized Andalusian patients |
| title_short |
Real world evidence of calcifediol or vitamin D prescription and mortality rate of COVID-19 in a retrospective cohort of hospitalized Andalusian patients |
| title_full |
Real world evidence of calcifediol or vitamin D prescription and mortality rate of COVID-19 in a retrospective cohort of hospitalized Andalusian patients |
| title_fullStr |
Real world evidence of calcifediol or vitamin D prescription and mortality rate of COVID-19 in a retrospective cohort of hospitalized Andalusian patients |
| title_full_unstemmed |
Real world evidence of calcifediol or vitamin D prescription and mortality rate of COVID-19 in a retrospective cohort of hospitalized Andalusian patients |
| title_sort |
real world evidence of calcifediol or vitamin d prescription and mortality rate of covid-19 in a retrospective cohort of hospitalized andalusian patients |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/e60b0cec7d2a476690fdd39128706327 |
| work_keys_str_mv |
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