Mouse Models of CMML

Mouse Models of CMML

Chronic myelomonocytic leukemia (CMML) is a rare and challenging type of myeloproliferative neoplasm. Poor prognosis and high mortality, associated predominantly with progression to secondary acute myeloid leukemia (sAML), is still an unsolved problem. Despite a growing body of knowledge about the m...

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Autores principales: Ekaterina Belotserkovskaya, Oleg Demidov
Formato: article
Lenguaje:EN
Publicado: MDPI AG 2021
Materias:
chronic myelomonocytic leukemia
CMML
mouse models
Biology (General)
QH301-705.5
Chemistry
QD1-999
Acceso en línea:https://doaj.org/article/e60b8e75e4e446f6b51e83cce56f0151
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spelling oai:doaj.org-article:e60b8e75e4e446f6b51e83cce56f01512021-11-11T16:58:17ZMouse Models of CMML10.3390/ijms2221115101422-00671661-6596https://doaj.org/article/e60b8e75e4e446f6b51e83cce56f01512021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11510https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Chronic myelomonocytic leukemia (CMML) is a rare and challenging type of myeloproliferative neoplasm. Poor prognosis and high mortality, associated predominantly with progression to secondary acute myeloid leukemia (sAML), is still an unsolved problem. Despite a growing body of knowledge about the molecular repertoire of this disease, at present, the prognostic significance of CMML-associated mutations is controversial. The absence of available CMML cell lines and the small number of patients with CMML make pre-clinical testing and clinical trials complicated. Currently, specific therapy for CMML has not been approved; most of the currently available therapeutic approaches are based on myelodysplastic syndrome (MDS) and other myeloproliferative neoplasm (MNP) studies. In this regard, the development of the robust CMML animal models is currently the focus of interest. This review describes important studies concerning animal models of CMML, examples of methodological approaches, and the obtained hematologic phenotypes.Ekaterina BelotserkovskayaOleg DemidovMDPI AGarticlechronic myelomonocytic leukemiaCMMLmouse modelsBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11510, p 11510 (2021)
institution DOAJ
collection DOAJ
language EN
topic chronic myelomonocytic leukemia
CMML
mouse models
Biology (General)
QH301-705.5
Chemistry
QD1-999
spellingShingle chronic myelomonocytic leukemia
CMML
mouse models
Biology (General)
QH301-705.5
Chemistry
QD1-999
Ekaterina Belotserkovskaya
Oleg Demidov
Mouse Models of CMML
description Chronic myelomonocytic leukemia (CMML) is a rare and challenging type of myeloproliferative neoplasm. Poor prognosis and high mortality, associated predominantly with progression to secondary acute myeloid leukemia (sAML), is still an unsolved problem. Despite a growing body of knowledge about the molecular repertoire of this disease, at present, the prognostic significance of CMML-associated mutations is controversial. The absence of available CMML cell lines and the small number of patients with CMML make pre-clinical testing and clinical trials complicated. Currently, specific therapy for CMML has not been approved; most of the currently available therapeutic approaches are based on myelodysplastic syndrome (MDS) and other myeloproliferative neoplasm (MNP) studies. In this regard, the development of the robust CMML animal models is currently the focus of interest. This review describes important studies concerning animal models of CMML, examples of methodological approaches, and the obtained hematologic phenotypes.
format article
author Ekaterina Belotserkovskaya
Oleg Demidov
author_facet Ekaterina Belotserkovskaya
Oleg Demidov
author_sort Ekaterina Belotserkovskaya
title Mouse Models of CMML
title_short Mouse Models of CMML
title_full Mouse Models of CMML
title_fullStr Mouse Models of CMML
title_full_unstemmed Mouse Models of CMML
title_sort mouse models of cmml
publisher MDPI AG
publishDate 2021
url https://doaj.org/article/e60b8e75e4e446f6b51e83cce56f0151
work_keys_str_mv AT ekaterinabelotserkovskaya mousemodelsofcmml
AT olegdemidov mousemodelsofcmml
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