Single-cell absolute contact probability detection reveals chromosomes are organized by multiple low-frequency yet specific interactions

Eukaryotic genomes are partitioned into self-interacting modules or topologically associated domains (TADs) that exist at the kilo-megabase scale. Here Cattoni et al. combine super-resolution microscopy with DNA-labeling methods to quantify absolute frequencies of interactions within TADs.

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Autores principales:	Diego I. Cattoni, Andrés M. Cardozo Gizzi, Mariya Georgieva, Marco Di Stefano, Alessandro Valeri, Delphine Chamousset, Christophe Houbron, Stephanie Déjardin, Jean-Bernard Fiche, Inma González, Jia-Ming Chang, Thomas Sexton, Marc A. Marti-Renom, Frédéric Bantignies, Giacomo Cavalli, Marcelo Nollmann
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e60cd11935584fd2817e693003fc822f
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spelling	oai:doaj.org-article:e60cd11935584fd2817e693003fc822f2021-12-02T16:51:52ZSingle-cell absolute contact probability detection reveals chromosomes are organized by multiple low-frequency yet specific interactions10.1038/s41467-017-01962-x2041-1723https://doaj.org/article/e60cd11935584fd2817e693003fc822f2017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01962-xhttps://doaj.org/toc/2041-1723Eukaryotic genomes are partitioned into self-interacting modules or topologically associated domains (TADs) that exist at the kilo-megabase scale. Here Cattoni et al. combine super-resolution microscopy with DNA-labeling methods to quantify absolute frequencies of interactions within TADs.Diego I. CattoniAndrés M. Cardozo GizziMariya GeorgievaMarco Di StefanoAlessandro ValeriDelphine ChamoussetChristophe HoubronStephanie DéjardinJean-Bernard FicheInma GonzálezJia-Ming ChangThomas SextonMarc A. Marti-RenomFrédéric BantigniesGiacomo CavalliMarcelo NollmannNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Diego I. Cattoni Andrés M. Cardozo Gizzi Mariya Georgieva Marco Di Stefano Alessandro Valeri Delphine Chamousset Christophe Houbron Stephanie Déjardin Jean-Bernard Fiche Inma González Jia-Ming Chang Thomas Sexton Marc A. Marti-Renom Frédéric Bantignies Giacomo Cavalli Marcelo Nollmann Single-cell absolute contact probability detection reveals chromosomes are organized by multiple low-frequency yet specific interactions
description	Eukaryotic genomes are partitioned into self-interacting modules or topologically associated domains (TADs) that exist at the kilo-megabase scale. Here Cattoni et al. combine super-resolution microscopy with DNA-labeling methods to quantify absolute frequencies of interactions within TADs.
format	article
author	Diego I. Cattoni Andrés M. Cardozo Gizzi Mariya Georgieva Marco Di Stefano Alessandro Valeri Delphine Chamousset Christophe Houbron Stephanie Déjardin Jean-Bernard Fiche Inma González Jia-Ming Chang Thomas Sexton Marc A. Marti-Renom Frédéric Bantignies Giacomo Cavalli Marcelo Nollmann
author_facet	Diego I. Cattoni Andrés M. Cardozo Gizzi Mariya Georgieva Marco Di Stefano Alessandro Valeri Delphine Chamousset Christophe Houbron Stephanie Déjardin Jean-Bernard Fiche Inma González Jia-Ming Chang Thomas Sexton Marc A. Marti-Renom Frédéric Bantignies Giacomo Cavalli Marcelo Nollmann
author_sort	Diego I. Cattoni
title	Single-cell absolute contact probability detection reveals chromosomes are organized by multiple low-frequency yet specific interactions
title_short	Single-cell absolute contact probability detection reveals chromosomes are organized by multiple low-frequency yet specific interactions
title_full	Single-cell absolute contact probability detection reveals chromosomes are organized by multiple low-frequency yet specific interactions
title_fullStr	Single-cell absolute contact probability detection reveals chromosomes are organized by multiple low-frequency yet specific interactions
title_full_unstemmed	Single-cell absolute contact probability detection reveals chromosomes are organized by multiple low-frequency yet specific interactions
title_sort	single-cell absolute contact probability detection reveals chromosomes are organized by multiple low-frequency yet specific interactions
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/e60cd11935584fd2817e693003fc822f
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Single-cell absolute contact probability detection reveals chromosomes are organized by multiple low-frequency yet specific interactions

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