Aspirin using was associated with slower cognitive decline in patients with Alzheimer's disease.

We aimed to examine whether the use of aspirin is associated with change in cognitive performance over time, and whether this association is modified by the cognitive stages. This study included a total of 1866 subjects, including 509 subjects with normal cognition (NC), 985 subjects with mild cogni...

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Autores principales:	Jinyan Weng, Guanan Zhao, Liyan Weng, Jingjing Guan, Alzheimer’s Disease Neuroimaging Initiative
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e6151b3c62494584b2931756251f6b47
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spelling	oai:doaj.org-article:e6151b3c62494584b2931756251f6b472021-12-02T20:15:48ZAspirin using was associated with slower cognitive decline in patients with Alzheimer's disease.1932-620310.1371/journal.pone.0252969https://doaj.org/article/e6151b3c62494584b2931756251f6b472021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0252969https://doaj.org/toc/1932-6203We aimed to examine whether the use of aspirin is associated with change in cognitive performance over time, and whether this association is modified by the cognitive stages. This study included a total of 1866 subjects, including 509 subjects with normal cognition (NC), 985 subjects with mild cognitive impairment (MCI), and 372 patients with Alzheimer's disease (AD). In each group, we further categorized our subjects into two groups based on their aspirin using conditions: Aspirin users and non-aspirin users. Mini-Mental State Examination (MMSE) was the cognitive outcome. Linear mixed models were conducted to examine the longitudinal relationship between the use of aspirin and cognitive performance in each diagnostic group. In the cross-sectional analysis, there were no significant differences in MMSE scores between non-aspirin users and aspirin users in subjects with NC, subjects with MCI or patients with AD. In the longitudinal analysis, we detected an association of the baseline use of aspirin with cognitive decline (MMSE) over time in patients with AD, but not in the NC group or MCI group. Specifically, in AD patients, the use of aspirin at baseline was associated with slower cognitive decline over time. Our data may support an association between the use of aspirin and slower cognitive decline, while this association may be dependent on the clinical stages.Jinyan WengGuanan ZhaoLiyan WengJingjing GuanAlzheimer’s Disease Neuroimaging InitiativePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 6, p e0252969 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jinyan Weng Guanan Zhao Liyan Weng Jingjing Guan Alzheimer’s Disease Neuroimaging Initiative Aspirin using was associated with slower cognitive decline in patients with Alzheimer's disease.
description	We aimed to examine whether the use of aspirin is associated with change in cognitive performance over time, and whether this association is modified by the cognitive stages. This study included a total of 1866 subjects, including 509 subjects with normal cognition (NC), 985 subjects with mild cognitive impairment (MCI), and 372 patients with Alzheimer's disease (AD). In each group, we further categorized our subjects into two groups based on their aspirin using conditions: Aspirin users and non-aspirin users. Mini-Mental State Examination (MMSE) was the cognitive outcome. Linear mixed models were conducted to examine the longitudinal relationship between the use of aspirin and cognitive performance in each diagnostic group. In the cross-sectional analysis, there were no significant differences in MMSE scores between non-aspirin users and aspirin users in subjects with NC, subjects with MCI or patients with AD. In the longitudinal analysis, we detected an association of the baseline use of aspirin with cognitive decline (MMSE) over time in patients with AD, but not in the NC group or MCI group. Specifically, in AD patients, the use of aspirin at baseline was associated with slower cognitive decline over time. Our data may support an association between the use of aspirin and slower cognitive decline, while this association may be dependent on the clinical stages.
format	article
author	Jinyan Weng Guanan Zhao Liyan Weng Jingjing Guan Alzheimer’s Disease Neuroimaging Initiative
author_facet	Jinyan Weng Guanan Zhao Liyan Weng Jingjing Guan Alzheimer’s Disease Neuroimaging Initiative
author_sort	Jinyan Weng
title	Aspirin using was associated with slower cognitive decline in patients with Alzheimer's disease.
title_short	Aspirin using was associated with slower cognitive decline in patients with Alzheimer's disease.
title_full	Aspirin using was associated with slower cognitive decline in patients with Alzheimer's disease.
title_fullStr	Aspirin using was associated with slower cognitive decline in patients with Alzheimer's disease.
title_full_unstemmed	Aspirin using was associated with slower cognitive decline in patients with Alzheimer's disease.
title_sort	aspirin using was associated with slower cognitive decline in patients with alzheimer's disease.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/e6151b3c62494584b2931756251f6b47
work_keys_str_mv	AT jinyanweng aspirinusingwasassociatedwithslowercognitivedeclineinpatientswithalzheimersdisease AT guananzhao aspirinusingwasassociatedwithslowercognitivedeclineinpatientswithalzheimersdisease AT liyanweng aspirinusingwasassociatedwithslowercognitivedeclineinpatientswithalzheimersdisease AT jingjingguan aspirinusingwasassociatedwithslowercognitivedeclineinpatientswithalzheimersdisease AT alzheimersdiseaseneuroimaginginitiative aspirinusingwasassociatedwithslowercognitivedeclineinpatientswithalzheimersdisease
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Aspirin using was associated with slower cognitive decline in patients with Alzheimer's disease.

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