PNLDC1 is essential for piRNA 3′ end trimming and transposon silencing during spermatogenesis in mice

piRNAs are regulatory RNAs that play a critical role in transposon silencing and gametogenesis. Here, the authors provide evidence that mammalian PNLDC1 is a regulator of piRNA biogenesis, transposon silencing and spermatogenesis, protecting the germline genome in mice.

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Autores principales:	Deqiang Ding, Jiali Liu, Kunzhe Dong, Uros Midic, Rex A. Hess, Huirong Xie, Elena Y. Demireva, Chen Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e61957ed5bdd4f0091b8c3b09bdab1f6
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spelling	oai:doaj.org-article:e61957ed5bdd4f0091b8c3b09bdab1f62021-12-02T17:06:23ZPNLDC1 is essential for piRNA 3′ end trimming and transposon silencing during spermatogenesis in mice10.1038/s41467-017-00854-42041-1723https://doaj.org/article/e61957ed5bdd4f0091b8c3b09bdab1f62017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00854-4https://doaj.org/toc/2041-1723piRNAs are regulatory RNAs that play a critical role in transposon silencing and gametogenesis. Here, the authors provide evidence that mammalian PNLDC1 is a regulator of piRNA biogenesis, transposon silencing and spermatogenesis, protecting the germline genome in mice.Deqiang DingJiali LiuKunzhe DongUros MidicRex A. HessHuirong XieElena Y. DemirevaChen ChenNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Deqiang Ding Jiali Liu Kunzhe Dong Uros Midic Rex A. Hess Huirong Xie Elena Y. Demireva Chen Chen PNLDC1 is essential for piRNA 3′ end trimming and transposon silencing during spermatogenesis in mice
description	piRNAs are regulatory RNAs that play a critical role in transposon silencing and gametogenesis. Here, the authors provide evidence that mammalian PNLDC1 is a regulator of piRNA biogenesis, transposon silencing and spermatogenesis, protecting the germline genome in mice.
format	article
author	Deqiang Ding Jiali Liu Kunzhe Dong Uros Midic Rex A. Hess Huirong Xie Elena Y. Demireva Chen Chen
author_facet	Deqiang Ding Jiali Liu Kunzhe Dong Uros Midic Rex A. Hess Huirong Xie Elena Y. Demireva Chen Chen
author_sort	Deqiang Ding
title	PNLDC1 is essential for piRNA 3′ end trimming and transposon silencing during spermatogenesis in mice
title_short	PNLDC1 is essential for piRNA 3′ end trimming and transposon silencing during spermatogenesis in mice
title_full	PNLDC1 is essential for piRNA 3′ end trimming and transposon silencing during spermatogenesis in mice
title_fullStr	PNLDC1 is essential for piRNA 3′ end trimming and transposon silencing during spermatogenesis in mice
title_full_unstemmed	PNLDC1 is essential for piRNA 3′ end trimming and transposon silencing during spermatogenesis in mice
title_sort	pnldc1 is essential for pirna 3′ end trimming and transposon silencing during spermatogenesis in mice
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/e61957ed5bdd4f0091b8c3b09bdab1f6
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PNLDC1 is essential for piRNA 3′ end trimming and transposon silencing during spermatogenesis in mice

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