PNLDC1 is essential for piRNA 3′ end trimming and transposon silencing during spermatogenesis in mice
piRNAs are regulatory RNAs that play a critical role in transposon silencing and gametogenesis. Here, the authors provide evidence that mammalian PNLDC1 is a regulator of piRNA biogenesis, transposon silencing and spermatogenesis, protecting the germline genome in mice.
Guardado en:
Autores principales: | Deqiang Ding, Jiali Liu, Kunzhe Dong, Uros Midic, Rex A. Hess, Huirong Xie, Elena Y. Demireva, Chen Chen |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2017
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Materias: | |
Acceso en línea: | https://doaj.org/article/e61957ed5bdd4f0091b8c3b09bdab1f6 |
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