Phylogenetic dependency networks: inferring patterns of CTL escape and codon covariation in HIV-1 Gag.
HIV avoids elimination by cytotoxic T-lymphocytes (CTLs) through the evolution of escape mutations. Although there is mounting evidence that these escape pathways are broadly consistent among individuals with similar human leukocyte antigen (HLA) class I alleles, previous population-based studies ha...
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Auteurs principaux: | Jonathan M Carlson, Zabrina L Brumme, Christine M Rousseau, Chanson J Brumme, Philippa Matthews, Carl Kadie, James I Mullins, Bruce D Walker, P Richard Harrigan, Philip J R Goulder, David Heckerman |
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Format: | article |
Langue: | EN |
Publié: |
Public Library of Science (PLoS)
2008
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Sujets: | |
Accès en ligne: | https://doaj.org/article/e61b6ed8a25c42d0982ce1e881a1fc15 |
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