Factors affecting high-sensitivity cardiac troponin T elevation in Japanese metabolic syndrome patients

Takashi Hitsumoto,1 Kohji Shirai2 1Hitsumoto Medical Clinic, Yamaguchi, Japan; 2Department of Vascular Function (donated), Sakura Hospital, Toho University School of Medicine, Chiba, Japan Purpose: The blood concentration of cardiac troponin T (ie, high-sensitivity cardiac troponin T [hs-cTnT]), m...

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Auteurs principaux:	Hitsumoto T, Shirai K
Format:	article
Langue:	EN
Publié:	Dove Medical Press 2015
Sujets:	Specialties of internal medicine RC581-951
Accès en ligne:	https://doaj.org/article/e61f36a1940c41959dd927030d7c244b
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spelling	oai:doaj.org-article:e61f36a1940c41959dd927030d7c244b2021-12-02T01:26:51ZFactors affecting high-sensitivity cardiac troponin T elevation in Japanese metabolic syndrome patients1178-7007https://doaj.org/article/e61f36a1940c41959dd927030d7c244b2015-03-01T00:00:00Zhttp://www.dovepress.com/factors-affecting-high-sensitivity-cardiac-troponin-t-elevation-in-jap-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007 Takashi Hitsumoto,1 Kohji Shirai2 1Hitsumoto Medical Clinic, Yamaguchi, Japan; 2Department of Vascular Function (donated), Sakura Hospital, Toho University School of Medicine, Chiba, Japan Purpose: The blood concentration of cardiac troponin T (ie, high-sensitivity cardiac troponin T [hs-cTnT]), measured using a highly sensitive assay, represents a useful biomarker for evaluating the pathogenesis of heart failure or predicting cardiovascular events. However, little is known about the clinical significance of hs-cTnT in metabolic syndrome. The aim of this study was to examine the factors affecting hs-cTnT elevation in Japanese metabolic syndrome patients. Patients and methods: We enrolled 258 metabolic syndrome patients who were middle-aged males without a history of cardiovascular events. We examined relationships between hs-cTnT and various clinical parameters, including diagnostic parameters of metabolic syndrome. Results: There were no significant correlations between hs-cTnT and diagnostic parameters of metabolic syndrome. However, hs-cTnT was significantly correlated with age (P<0.01), blood concentrations of brain natriuretic peptide (P<0.01), reactive oxygen metabolites (markers of oxidative stress, P<0.001), and the cardio–ankle vascular index (marker of arterial function, P<0.01). Furthermore, multiple regression analysis revealed that these factors were independent variables for hs-cTnT as a subordinate factor. Conclusion: The findings of this study indicate that in vivo oxidative stress and abnormality of arterial function are closely associated with an increase in hs-cTnT concentrations in Japanese metabolic syndrome patients. Keywords: troponin, metabolic syndrome, risk factor, oxidative stress, cardio–ankle vascular indexHitsumoto TShirai KDove Medical PressarticleSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol 2015, Iss default, Pp 157-162 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Specialties of internal medicine RC581-951
spellingShingle	Specialties of internal medicine RC581-951 Hitsumoto T Shirai K Factors affecting high-sensitivity cardiac troponin T elevation in Japanese metabolic syndrome patients
description	Takashi Hitsumoto,1 Kohji Shirai2 1Hitsumoto Medical Clinic, Yamaguchi, Japan; 2Department of Vascular Function (donated), Sakura Hospital, Toho University School of Medicine, Chiba, Japan Purpose: The blood concentration of cardiac troponin T (ie, high-sensitivity cardiac troponin T [hs-cTnT]), measured using a highly sensitive assay, represents a useful biomarker for evaluating the pathogenesis of heart failure or predicting cardiovascular events. However, little is known about the clinical significance of hs-cTnT in metabolic syndrome. The aim of this study was to examine the factors affecting hs-cTnT elevation in Japanese metabolic syndrome patients. Patients and methods: We enrolled 258 metabolic syndrome patients who were middle-aged males without a history of cardiovascular events. We examined relationships between hs-cTnT and various clinical parameters, including diagnostic parameters of metabolic syndrome. Results: There were no significant correlations between hs-cTnT and diagnostic parameters of metabolic syndrome. However, hs-cTnT was significantly correlated with age (P<0.01), blood concentrations of brain natriuretic peptide (P<0.01), reactive oxygen metabolites (markers of oxidative stress, P<0.001), and the cardio–ankle vascular index (marker of arterial function, P<0.01). Furthermore, multiple regression analysis revealed that these factors were independent variables for hs-cTnT as a subordinate factor. Conclusion: The findings of this study indicate that in vivo oxidative stress and abnormality of arterial function are closely associated with an increase in hs-cTnT concentrations in Japanese metabolic syndrome patients. Keywords: troponin, metabolic syndrome, risk factor, oxidative stress, cardio–ankle vascular index
format	article
author	Hitsumoto T Shirai K
author_facet	Hitsumoto T Shirai K
author_sort	Hitsumoto T
title	Factors affecting high-sensitivity cardiac troponin T elevation in Japanese metabolic syndrome patients
title_short	Factors affecting high-sensitivity cardiac troponin T elevation in Japanese metabolic syndrome patients
title_full	Factors affecting high-sensitivity cardiac troponin T elevation in Japanese metabolic syndrome patients
title_fullStr	Factors affecting high-sensitivity cardiac troponin T elevation in Japanese metabolic syndrome patients
title_full_unstemmed	Factors affecting high-sensitivity cardiac troponin T elevation in Japanese metabolic syndrome patients
title_sort	factors affecting high-sensitivity cardiac troponin t elevation in japanese metabolic syndrome patients
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/e61f36a1940c41959dd927030d7c244b
work_keys_str_mv	AT hitsumotot factorsaffectinghighsensitivitycardiactroponintelevationinjapanesemetabolicsyndromepatients AT shiraik factorsaffectinghighsensitivitycardiactroponintelevationinjapanesemetabolicsyndromepatients
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Factors affecting high-sensitivity cardiac troponin T elevation in Japanese metabolic syndrome patients

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