Alcohol Consumption Moderated the Association Between Levels of High Blood Lead or Total Urinary Arsenic and Bone Loss

Metal exposure and lifestyle are important risk factors for osteoporosis. Our study aimed to investigate the association between red blood cell lead and cadmium, total urinary arsenic, and plasma selenium levels and bone mineral density (BMD). In addition, we explored whether alcohol and coffee cons...

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Autores principales:	Yu-Mei Hsueh, Ya-Li Huang, Hsi-Hsien Chen, Horng-Sheng Shiue, Ying-Chin Lin, Ru-Lan Hsieh
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	alcohol coffee arsenic lead bone mineral density Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/e62251e8570c444eae92c1e78e40ab96
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spelling	oai:doaj.org-article:e62251e8570c444eae92c1e78e40ab962021-12-03T10:06:54ZAlcohol Consumption Moderated the Association Between Levels of High Blood Lead or Total Urinary Arsenic and Bone Loss1664-239210.3389/fendo.2021.782174https://doaj.org/article/e62251e8570c444eae92c1e78e40ab962021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fendo.2021.782174/fullhttps://doaj.org/toc/1664-2392Metal exposure and lifestyle are important risk factors for osteoporosis. Our study aimed to investigate the association between red blood cell lead and cadmium, total urinary arsenic, and plasma selenium levels and bone mineral density (BMD). In addition, we explored whether alcohol and coffee consumption modified the association between BMD and metals and metalloids. In total, 437 participants who underwent adult or senile physical examinations were recruited. Bone loss was defined as a calcaneus BMD T-score of <-1. Blood cadmium and lead and plasma selenium levels were measured using inductively coupled plasma mass spectrometry. Levels of urinary arsenic species were determined using high-performance liquid chromatography–hydride generator–atomic absorption spectrometry. The total urinary arsenic level was defined as the sum of the levels of urinary arsenic species. The BMD T-scores decreased significantly with increasing blood lead levels. The BMD T-scores also showed a downward trend with increasing total urinary arsenic levels. The odds ratio (OR) and 95% confidence interval (CI) for bone loss in patients with blood lead levels >57.58 versus 35.74 μg/dL were 1.98 and 1.17–3.34. In addition, the greater the lead or arsenic exposure and alcohol intake was the higher the OR for bone loss with multivariate ORs of 2.57 (95% CI 1.45–4.56) and 2.96 (95% CI 1.67–5.22), respectively. To the best of our knowledge, this study is the first to demonstrate that high total urinary arsenic or blood lead levels and frequent or occasional alcohol consumption had a significant multiplicative interaction for increasing the OR for bone loss.Yu-Mei HsuehYu-Mei HsuehYa-Li HuangHsi-Hsien ChenHsi-Hsien ChenHorng-Sheng ShiueYing-Chin LinYing-Chin LinYing-Chin LinRu-Lan HsiehRu-Lan HsiehFrontiers Media S.A.articlealcoholcoffeearsenicleadbone mineral densityDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENFrontiers in Endocrinology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	alcohol coffee arsenic lead bone mineral density Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	alcohol coffee arsenic lead bone mineral density Diseases of the endocrine glands. Clinical endocrinology RC648-665 Yu-Mei Hsueh Yu-Mei Hsueh Ya-Li Huang Hsi-Hsien Chen Hsi-Hsien Chen Horng-Sheng Shiue Ying-Chin Lin Ying-Chin Lin Ying-Chin Lin Ru-Lan Hsieh Ru-Lan Hsieh Alcohol Consumption Moderated the Association Between Levels of High Blood Lead or Total Urinary Arsenic and Bone Loss
description	Metal exposure and lifestyle are important risk factors for osteoporosis. Our study aimed to investigate the association between red blood cell lead and cadmium, total urinary arsenic, and plasma selenium levels and bone mineral density (BMD). In addition, we explored whether alcohol and coffee consumption modified the association between BMD and metals and metalloids. In total, 437 participants who underwent adult or senile physical examinations were recruited. Bone loss was defined as a calcaneus BMD T-score of <-1. Blood cadmium and lead and plasma selenium levels were measured using inductively coupled plasma mass spectrometry. Levels of urinary arsenic species were determined using high-performance liquid chromatography–hydride generator–atomic absorption spectrometry. The total urinary arsenic level was defined as the sum of the levels of urinary arsenic species. The BMD T-scores decreased significantly with increasing blood lead levels. The BMD T-scores also showed a downward trend with increasing total urinary arsenic levels. The odds ratio (OR) and 95% confidence interval (CI) for bone loss in patients with blood lead levels >57.58 versus 35.74 μg/dL were 1.98 and 1.17–3.34. In addition, the greater the lead or arsenic exposure and alcohol intake was the higher the OR for bone loss with multivariate ORs of 2.57 (95% CI 1.45–4.56) and 2.96 (95% CI 1.67–5.22), respectively. To the best of our knowledge, this study is the first to demonstrate that high total urinary arsenic or blood lead levels and frequent or occasional alcohol consumption had a significant multiplicative interaction for increasing the OR for bone loss.
format	article
author	Yu-Mei Hsueh Yu-Mei Hsueh Ya-Li Huang Hsi-Hsien Chen Hsi-Hsien Chen Horng-Sheng Shiue Ying-Chin Lin Ying-Chin Lin Ying-Chin Lin Ru-Lan Hsieh Ru-Lan Hsieh
author_facet	Yu-Mei Hsueh Yu-Mei Hsueh Ya-Li Huang Hsi-Hsien Chen Hsi-Hsien Chen Horng-Sheng Shiue Ying-Chin Lin Ying-Chin Lin Ying-Chin Lin Ru-Lan Hsieh Ru-Lan Hsieh
author_sort	Yu-Mei Hsueh
title	Alcohol Consumption Moderated the Association Between Levels of High Blood Lead or Total Urinary Arsenic and Bone Loss
title_short	Alcohol Consumption Moderated the Association Between Levels of High Blood Lead or Total Urinary Arsenic and Bone Loss
title_full	Alcohol Consumption Moderated the Association Between Levels of High Blood Lead or Total Urinary Arsenic and Bone Loss
title_fullStr	Alcohol Consumption Moderated the Association Between Levels of High Blood Lead or Total Urinary Arsenic and Bone Loss
title_full_unstemmed	Alcohol Consumption Moderated the Association Between Levels of High Blood Lead or Total Urinary Arsenic and Bone Loss
title_sort	alcohol consumption moderated the association between levels of high blood lead or total urinary arsenic and bone loss
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/e62251e8570c444eae92c1e78e40ab96
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Alcohol Consumption Moderated the Association Between Levels of High Blood Lead or Total Urinary Arsenic and Bone Loss

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