Critical role of the HDAC6–cortactin axis in human megakaryocyte maturation leading to a proplatelet-formation defect

Histone deacetylase (HDAC) inhibitors, a class of cancer therapeutics, cause thrombocytopenia via an unknown mechanism. Here, the authors show that HDAC6 inhibition impairs proplatelet formation in human megakaryocytes, and show that this is linked to hyperacetylation of the actin-binding protein co...

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Autores principales:	Kahia Messaoudi, Ashfaq Ali, Rameez Ishaq, Alberta Palazzo, Dominika Sliwa, Olivier Bluteau, Sylvie Souquère, Delphine Muller, Khadija M. Diop, Philippe Rameau, Valérie Lapierre, Jean-Pierre Marolleau, Patrick Matthias, Isabelle Godin, Gérard Pierron, Steven G. Thomas, Stephen P. Watson, Nathalie Droin, William Vainchenker, Isabelle Plo, Hana Raslova, Najet Debili
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e6244d22664d4e168a0d548e8a713d18
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spelling	oai:doaj.org-article:e6244d22664d4e168a0d548e8a713d182021-12-02T14:40:49ZCritical role of the HDAC6–cortactin axis in human megakaryocyte maturation leading to a proplatelet-formation defect10.1038/s41467-017-01690-22041-1723https://doaj.org/article/e6244d22664d4e168a0d548e8a713d182017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01690-2https://doaj.org/toc/2041-1723Histone deacetylase (HDAC) inhibitors, a class of cancer therapeutics, cause thrombocytopenia via an unknown mechanism. Here, the authors show that HDAC6 inhibition impairs proplatelet formation in human megakaryocytes, and show that this is linked to hyperacetylation of the actin-binding protein cortactin.Kahia MessaoudiAshfaq AliRameez IshaqAlberta PalazzoDominika SliwaOlivier BluteauSylvie SouquèreDelphine MullerKhadija M. DiopPhilippe RameauValérie LapierreJean-Pierre MarolleauPatrick MatthiasIsabelle GodinGérard PierronSteven G. ThomasStephen P. WatsonNathalie DroinWilliam VainchenkerIsabelle PloHana RaslovaNajet DebiliNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kahia Messaoudi Ashfaq Ali Rameez Ishaq Alberta Palazzo Dominika Sliwa Olivier Bluteau Sylvie Souquère Delphine Muller Khadija M. Diop Philippe Rameau Valérie Lapierre Jean-Pierre Marolleau Patrick Matthias Isabelle Godin Gérard Pierron Steven G. Thomas Stephen P. Watson Nathalie Droin William Vainchenker Isabelle Plo Hana Raslova Najet Debili Critical role of the HDAC6–cortactin axis in human megakaryocyte maturation leading to a proplatelet-formation defect
description	Histone deacetylase (HDAC) inhibitors, a class of cancer therapeutics, cause thrombocytopenia via an unknown mechanism. Here, the authors show that HDAC6 inhibition impairs proplatelet formation in human megakaryocytes, and show that this is linked to hyperacetylation of the actin-binding protein cortactin.
format	article
author	Kahia Messaoudi Ashfaq Ali Rameez Ishaq Alberta Palazzo Dominika Sliwa Olivier Bluteau Sylvie Souquère Delphine Muller Khadija M. Diop Philippe Rameau Valérie Lapierre Jean-Pierre Marolleau Patrick Matthias Isabelle Godin Gérard Pierron Steven G. Thomas Stephen P. Watson Nathalie Droin William Vainchenker Isabelle Plo Hana Raslova Najet Debili
author_facet	Kahia Messaoudi Ashfaq Ali Rameez Ishaq Alberta Palazzo Dominika Sliwa Olivier Bluteau Sylvie Souquère Delphine Muller Khadija M. Diop Philippe Rameau Valérie Lapierre Jean-Pierre Marolleau Patrick Matthias Isabelle Godin Gérard Pierron Steven G. Thomas Stephen P. Watson Nathalie Droin William Vainchenker Isabelle Plo Hana Raslova Najet Debili
author_sort	Kahia Messaoudi
title	Critical role of the HDAC6–cortactin axis in human megakaryocyte maturation leading to a proplatelet-formation defect
title_short	Critical role of the HDAC6–cortactin axis in human megakaryocyte maturation leading to a proplatelet-formation defect
title_full	Critical role of the HDAC6–cortactin axis in human megakaryocyte maturation leading to a proplatelet-formation defect
title_fullStr	Critical role of the HDAC6–cortactin axis in human megakaryocyte maturation leading to a proplatelet-formation defect
title_full_unstemmed	Critical role of the HDAC6–cortactin axis in human megakaryocyte maturation leading to a proplatelet-formation defect
title_sort	critical role of the hdac6–cortactin axis in human megakaryocyte maturation leading to a proplatelet-formation defect
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/e6244d22664d4e168a0d548e8a713d18
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Critical role of the HDAC6–cortactin axis in human megakaryocyte maturation leading to a proplatelet-formation defect

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