Target engagement imaging of PARP inhibitors in small-cell lung cancer

Treatment of small-cell lung cancer remains a challenge due to multiple mechanisms of resistance to current therapies; measuring patient response is crucial in adapting and choosing adequate treatment. Here the authors develop a strategy to visualise in vivo dynamics of a class of widely used PARP i...

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Autores principales:	Brandon Carney, Susanne Kossatz, Benjamin H. Lok, Valentina Schneeberger, Kishore K. Gangangari, Naga Vara Kishore Pillarsetty, Wolfgang A. Weber, Charles M. Rudin, John T. Poirier, Thomas Reiner
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e625a8f0d4ae4e3f93d027d2afb43df5
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spelling	oai:doaj.org-article:e625a8f0d4ae4e3f93d027d2afb43df52021-12-02T16:49:50ZTarget engagement imaging of PARP inhibitors in small-cell lung cancer10.1038/s41467-017-02096-w2041-1723https://doaj.org/article/e625a8f0d4ae4e3f93d027d2afb43df52018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02096-whttps://doaj.org/toc/2041-1723Treatment of small-cell lung cancer remains a challenge due to multiple mechanisms of resistance to current therapies; measuring patient response is crucial in adapting and choosing adequate treatment. Here the authors develop a strategy to visualise in vivo dynamics of a class of widely used PARP inhibitors.Brandon CarneySusanne KossatzBenjamin H. LokValentina SchneebergerKishore K. GangangariNaga Vara Kishore PillarsettyWolfgang A. WeberCharles M. RudinJohn T. PoirierThomas ReinerNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Brandon Carney Susanne Kossatz Benjamin H. Lok Valentina Schneeberger Kishore K. Gangangari Naga Vara Kishore Pillarsetty Wolfgang A. Weber Charles M. Rudin John T. Poirier Thomas Reiner Target engagement imaging of PARP inhibitors in small-cell lung cancer
description	Treatment of small-cell lung cancer remains a challenge due to multiple mechanisms of resistance to current therapies; measuring patient response is crucial in adapting and choosing adequate treatment. Here the authors develop a strategy to visualise in vivo dynamics of a class of widely used PARP inhibitors.
format	article
author	Brandon Carney Susanne Kossatz Benjamin H. Lok Valentina Schneeberger Kishore K. Gangangari Naga Vara Kishore Pillarsetty Wolfgang A. Weber Charles M. Rudin John T. Poirier Thomas Reiner
author_facet	Brandon Carney Susanne Kossatz Benjamin H. Lok Valentina Schneeberger Kishore K. Gangangari Naga Vara Kishore Pillarsetty Wolfgang A. Weber Charles M. Rudin John T. Poirier Thomas Reiner
author_sort	Brandon Carney
title	Target engagement imaging of PARP inhibitors in small-cell lung cancer
title_short	Target engagement imaging of PARP inhibitors in small-cell lung cancer
title_full	Target engagement imaging of PARP inhibitors in small-cell lung cancer
title_fullStr	Target engagement imaging of PARP inhibitors in small-cell lung cancer
title_full_unstemmed	Target engagement imaging of PARP inhibitors in small-cell lung cancer
title_sort	target engagement imaging of parp inhibitors in small-cell lung cancer
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/e625a8f0d4ae4e3f93d027d2afb43df5
work_keys_str_mv	AT brandoncarney targetengagementimagingofparpinhibitorsinsmallcelllungcancer AT susannekossatz targetengagementimagingofparpinhibitorsinsmallcelllungcancer AT benjaminhlok targetengagementimagingofparpinhibitorsinsmallcelllungcancer AT valentinaschneeberger targetengagementimagingofparpinhibitorsinsmallcelllungcancer AT kishorekgangangari targetengagementimagingofparpinhibitorsinsmallcelllungcancer AT nagavarakishorepillarsetty targetengagementimagingofparpinhibitorsinsmallcelllungcancer AT wolfgangaweber targetengagementimagingofparpinhibitorsinsmallcelllungcancer AT charlesmrudin targetengagementimagingofparpinhibitorsinsmallcelllungcancer AT johntpoirier targetengagementimagingofparpinhibitorsinsmallcelllungcancer AT thomasreiner targetengagementimagingofparpinhibitorsinsmallcelllungcancer
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Target engagement imaging of PARP inhibitors in small-cell lung cancer

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