Selective targeting of ligand-dependent and -independent signaling by GPCR conformation-specific anti-US28 intrabodies

Selective targeting of ligand-dependent and -independent signaling by GPCR conformation-specific anti-US28 intrabodies

Various GPCRs display constitutive ligand-independent activity, but it remains unclear whether ligand-dependent and -independent conformations differ. Here the authors demonstrate the recognition and blocking of G protein recruitment of either the ligand-bound active, or the constitutively active ap...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Timo W. M. De Groof, Nick D. Bergkamp, Raimond Heukers, Truc Giap, Maarten P. Bebelman, Richard Goeij-de Haas, Sander R. Piersma, Connie R. Jimenez, K. Christopher Garcia, Hidde L. Ploegh, Marco Siderius, Martine J. Smit
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/e627ed6b73f44763bda4541f3d3a971b
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
Descripción
Sumario:Various GPCRs display constitutive ligand-independent activity, but it remains unclear whether ligand-dependent and -independent conformations differ. Here the authors demonstrate the recognition and blocking of G protein recruitment of either the ligand-bound active, or the constitutively active apo-conformation of the viral GPCR US28 by different nanobodies that target similar intracellular loops of the receptor.

Ejemplares similares