Affinity proteomics reveals elevated muscle proteins in plasma of children with cerebral malaria.
Systemic inflammation and sequestration of parasitized erythrocytes are central processes in the pathophysiology of severe Plasmodium falciparum childhood malaria. However, it is still not understood why some children are more at risks to develop malaria complications than others. To identify human...
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2014
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oai:doaj.org-article:e6292abf45204a8aaa9eadf250d5e8d42021-11-18T06:06:42ZAffinity proteomics reveals elevated muscle proteins in plasma of children with cerebral malaria.1553-73661553-737410.1371/journal.ppat.1004038https://doaj.org/article/e6292abf45204a8aaa9eadf250d5e8d42014-04-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24743550/?tool=EBIhttps://doaj.org/toc/1553-7366https://doaj.org/toc/1553-7374Systemic inflammation and sequestration of parasitized erythrocytes are central processes in the pathophysiology of severe Plasmodium falciparum childhood malaria. However, it is still not understood why some children are more at risks to develop malaria complications than others. To identify human proteins in plasma related to childhood malaria syndromes, multiplex antibody suspension bead arrays were employed. Out of the 1,015 proteins analyzed in plasma from more than 700 children, 41 differed between malaria infected children and community controls, whereas 13 discriminated uncomplicated malaria from severe malaria syndromes. Markers of oxidative stress were found related to severe malaria anemia while markers of endothelial activation, platelet adhesion and muscular damage were identified in relation to children with cerebral malaria. These findings suggest the presence of generalized vascular inflammation, vascular wall modulations, activation of endothelium and unbalanced glucose metabolism in severe malaria. The increased levels of specific muscle proteins in plasma implicate potential muscle damage and microvasculature lesions during the course of cerebral malaria.Julie BachmannFlorence BurtéSetia PramanaIanina ConteBiobele J BrownAdebola E OrimadegunWasiu A AjetunmobiNathaniel K AfolabiFrancis AkinkunmiSamuel OmokhodionFelix O AkinbamiWuraola A ShokunbiCaroline KampfYudi PawitanMathias UhlénOlugbemiro SodeindeJochen M SchwenkMats WahlgrenDelmiro Fernandez-ReyesPeter NilssonPublic Library of Science (PLoS)articleImmunologic diseases. AllergyRC581-607Biology (General)QH301-705.5ENPLoS Pathogens, Vol 10, Iss 4, p e1004038 (2014) |
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Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 |
| spellingShingle |
Immunologic diseases. Allergy RC581-607 Biology (General) QH301-705.5 Julie Bachmann Florence Burté Setia Pramana Ianina Conte Biobele J Brown Adebola E Orimadegun Wasiu A Ajetunmobi Nathaniel K Afolabi Francis Akinkunmi Samuel Omokhodion Felix O Akinbami Wuraola A Shokunbi Caroline Kampf Yudi Pawitan Mathias Uhlén Olugbemiro Sodeinde Jochen M Schwenk Mats Wahlgren Delmiro Fernandez-Reyes Peter Nilsson Affinity proteomics reveals elevated muscle proteins in plasma of children with cerebral malaria. |
| description |
Systemic inflammation and sequestration of parasitized erythrocytes are central processes in the pathophysiology of severe Plasmodium falciparum childhood malaria. However, it is still not understood why some children are more at risks to develop malaria complications than others. To identify human proteins in plasma related to childhood malaria syndromes, multiplex antibody suspension bead arrays were employed. Out of the 1,015 proteins analyzed in plasma from more than 700 children, 41 differed between malaria infected children and community controls, whereas 13 discriminated uncomplicated malaria from severe malaria syndromes. Markers of oxidative stress were found related to severe malaria anemia while markers of endothelial activation, platelet adhesion and muscular damage were identified in relation to children with cerebral malaria. These findings suggest the presence of generalized vascular inflammation, vascular wall modulations, activation of endothelium and unbalanced glucose metabolism in severe malaria. The increased levels of specific muscle proteins in plasma implicate potential muscle damage and microvasculature lesions during the course of cerebral malaria. |
| format |
article |
| author |
Julie Bachmann Florence Burté Setia Pramana Ianina Conte Biobele J Brown Adebola E Orimadegun Wasiu A Ajetunmobi Nathaniel K Afolabi Francis Akinkunmi Samuel Omokhodion Felix O Akinbami Wuraola A Shokunbi Caroline Kampf Yudi Pawitan Mathias Uhlén Olugbemiro Sodeinde Jochen M Schwenk Mats Wahlgren Delmiro Fernandez-Reyes Peter Nilsson |
| author_facet |
Julie Bachmann Florence Burté Setia Pramana Ianina Conte Biobele J Brown Adebola E Orimadegun Wasiu A Ajetunmobi Nathaniel K Afolabi Francis Akinkunmi Samuel Omokhodion Felix O Akinbami Wuraola A Shokunbi Caroline Kampf Yudi Pawitan Mathias Uhlén Olugbemiro Sodeinde Jochen M Schwenk Mats Wahlgren Delmiro Fernandez-Reyes Peter Nilsson |
| author_sort |
Julie Bachmann |
| title |
Affinity proteomics reveals elevated muscle proteins in plasma of children with cerebral malaria. |
| title_short |
Affinity proteomics reveals elevated muscle proteins in plasma of children with cerebral malaria. |
| title_full |
Affinity proteomics reveals elevated muscle proteins in plasma of children with cerebral malaria. |
| title_fullStr |
Affinity proteomics reveals elevated muscle proteins in plasma of children with cerebral malaria. |
| title_full_unstemmed |
Affinity proteomics reveals elevated muscle proteins in plasma of children with cerebral malaria. |
| title_sort |
affinity proteomics reveals elevated muscle proteins in plasma of children with cerebral malaria. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2014 |
| url |
https://doaj.org/article/e6292abf45204a8aaa9eadf250d5e8d4 |
| work_keys_str_mv |
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