The Specific Vulnerabilities of Cancer Cells to the Cold Atmospheric Plasma-Stimulated Solutions

Abstract Cold atmospheric plasma (CAP), a novel promising anti-cancer modality, has shown its selective anti-cancer capacity on dozens of cancer cell lines in vitro and on subcutaneous xenograft tumors in mice. Over the past five years, the CAP-stimulated solutions (PSS) have also shown their select...

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Autores principales:	Dayun Yan, Haitao Cui, Wei Zhu, Niki Nourmohammadi, Julian Milberg, Lijie G. Zhang, Jonathan H. Sherman, Michael Keidar
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/e629a71d4a88441f8fed68fdb5fc16e1
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spelling	oai:doaj.org-article:e629a71d4a88441f8fed68fdb5fc16e12021-12-02T15:05:22ZThe Specific Vulnerabilities of Cancer Cells to the Cold Atmospheric Plasma-Stimulated Solutions10.1038/s41598-017-04770-x2045-2322https://doaj.org/article/e629a71d4a88441f8fed68fdb5fc16e12017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-04770-xhttps://doaj.org/toc/2045-2322Abstract Cold atmospheric plasma (CAP), a novel promising anti-cancer modality, has shown its selective anti-cancer capacity on dozens of cancer cell lines in vitro and on subcutaneous xenograft tumors in mice. Over the past five years, the CAP-stimulated solutions (PSS) have also shown their selective anti-cancer effect over different cancers in vitro and in vivo. The solutions used to make PSS include several bio-adaptable solutions, mainly cell culture medium and simple buffered solutions. Both the CAP-stimulated medium (PSM) and the CAP-stimulated buffered solution (PSB) are able to significantly kill cancer cells in vitro. In this study, we systematically compared the anti-cancer effect of PSM and PSB over pancreatic adenocarcinoma cells and glioblastoma cells. We demonstrated that pancreatic cancer cells and glioblastoma cells were specifically vulnerable to PSM and PSB, respectively. The specific response such as the rise of intracellular reactive oxygen species of two cancer cell lines to the H2O2-containing environments might result in the specific vulnerabilities to PSM and PSB. In addition, we demonstrated a basic guideline that the toxicity of PSS on cancer cells could be significantly modulated through controlling the dilutability of solution.Dayun YanHaitao CuiWei ZhuNiki NourmohammadiJulian MilbergLijie G. ZhangJonathan H. ShermanMichael KeidarNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Dayun Yan Haitao Cui Wei Zhu Niki Nourmohammadi Julian Milberg Lijie G. Zhang Jonathan H. Sherman Michael Keidar The Specific Vulnerabilities of Cancer Cells to the Cold Atmospheric Plasma-Stimulated Solutions
description	Abstract Cold atmospheric plasma (CAP), a novel promising anti-cancer modality, has shown its selective anti-cancer capacity on dozens of cancer cell lines in vitro and on subcutaneous xenograft tumors in mice. Over the past five years, the CAP-stimulated solutions (PSS) have also shown their selective anti-cancer effect over different cancers in vitro and in vivo. The solutions used to make PSS include several bio-adaptable solutions, mainly cell culture medium and simple buffered solutions. Both the CAP-stimulated medium (PSM) and the CAP-stimulated buffered solution (PSB) are able to significantly kill cancer cells in vitro. In this study, we systematically compared the anti-cancer effect of PSM and PSB over pancreatic adenocarcinoma cells and glioblastoma cells. We demonstrated that pancreatic cancer cells and glioblastoma cells were specifically vulnerable to PSM and PSB, respectively. The specific response such as the rise of intracellular reactive oxygen species of two cancer cell lines to the H2O2-containing environments might result in the specific vulnerabilities to PSM and PSB. In addition, we demonstrated a basic guideline that the toxicity of PSS on cancer cells could be significantly modulated through controlling the dilutability of solution.
format	article
author	Dayun Yan Haitao Cui Wei Zhu Niki Nourmohammadi Julian Milberg Lijie G. Zhang Jonathan H. Sherman Michael Keidar
author_facet	Dayun Yan Haitao Cui Wei Zhu Niki Nourmohammadi Julian Milberg Lijie G. Zhang Jonathan H. Sherman Michael Keidar
author_sort	Dayun Yan
title	The Specific Vulnerabilities of Cancer Cells to the Cold Atmospheric Plasma-Stimulated Solutions
title_short	The Specific Vulnerabilities of Cancer Cells to the Cold Atmospheric Plasma-Stimulated Solutions
title_full	The Specific Vulnerabilities of Cancer Cells to the Cold Atmospheric Plasma-Stimulated Solutions
title_fullStr	The Specific Vulnerabilities of Cancer Cells to the Cold Atmospheric Plasma-Stimulated Solutions
title_full_unstemmed	The Specific Vulnerabilities of Cancer Cells to the Cold Atmospheric Plasma-Stimulated Solutions
title_sort	specific vulnerabilities of cancer cells to the cold atmospheric plasma-stimulated solutions
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/e629a71d4a88441f8fed68fdb5fc16e1
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The Specific Vulnerabilities of Cancer Cells to the Cold Atmospheric Plasma-Stimulated Solutions

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