The natural function of the malaria parasite’s chloroquine resistance transporter

Plasmodium falciparum chloroquine resistance transporter (PfCRT) mediates multidrug resistance, but its natural function remains unclear. Here, Shafik et al. show that PfCRT transports host-derived peptides of 4-11 residues but not other ions or metabolites, and that drug-resistance-conferring PfCRT...

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Main Authors:	Sarah H. Shafik, Simon A. Cobbold, Kawthar Barkat, Sashika N. Richards, Nicole S. Lancaster, Manuel Llinás, Simon J. Hogg, Robert L. Summers, Malcolm J. McConville, Rowena E. Martin
Format:	article
Language:	EN
Published:	Nature Portfolio 2020
Subjects:	Science Q
Online Access:	https://doaj.org/article/e62a9cfeb1b74e3793184dbfb72b16f7
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spelling	oai:doaj.org-article:e62a9cfeb1b74e3793184dbfb72b16f72021-12-02T17:06:27ZThe natural function of the malaria parasite’s chloroquine resistance transporter10.1038/s41467-020-17781-62041-1723https://doaj.org/article/e62a9cfeb1b74e3793184dbfb72b16f72020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17781-6https://doaj.org/toc/2041-1723Plasmodium falciparum chloroquine resistance transporter (PfCRT) mediates multidrug resistance, but its natural function remains unclear. Here, Shafik et al. show that PfCRT transports host-derived peptides of 4-11 residues but not other ions or metabolites, and that drug-resistance-conferring PfCRT mutants have reduced peptide transport.Sarah H. ShafikSimon A. CobboldKawthar BarkatSashika N. RichardsNicole S. LancasterManuel LlinásSimon J. HoggRobert L. SummersMalcolm J. McConvilleRowena E. MartinNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sarah H. Shafik Simon A. Cobbold Kawthar Barkat Sashika N. Richards Nicole S. Lancaster Manuel Llinás Simon J. Hogg Robert L. Summers Malcolm J. McConville Rowena E. Martin The natural function of the malaria parasite’s chloroquine resistance transporter
description	Plasmodium falciparum chloroquine resistance transporter (PfCRT) mediates multidrug resistance, but its natural function remains unclear. Here, Shafik et al. show that PfCRT transports host-derived peptides of 4-11 residues but not other ions or metabolites, and that drug-resistance-conferring PfCRT mutants have reduced peptide transport.
format	article
author	Sarah H. Shafik Simon A. Cobbold Kawthar Barkat Sashika N. Richards Nicole S. Lancaster Manuel Llinás Simon J. Hogg Robert L. Summers Malcolm J. McConville Rowena E. Martin
author_facet	Sarah H. Shafik Simon A. Cobbold Kawthar Barkat Sashika N. Richards Nicole S. Lancaster Manuel Llinás Simon J. Hogg Robert L. Summers Malcolm J. McConville Rowena E. Martin
author_sort	Sarah H. Shafik
title	The natural function of the malaria parasite’s chloroquine resistance transporter
title_short	The natural function of the malaria parasite’s chloroquine resistance transporter
title_full	The natural function of the malaria parasite’s chloroquine resistance transporter
title_fullStr	The natural function of the malaria parasite’s chloroquine resistance transporter
title_full_unstemmed	The natural function of the malaria parasite’s chloroquine resistance transporter
title_sort	natural function of the malaria parasite’s chloroquine resistance transporter
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/e62a9cfeb1b74e3793184dbfb72b16f7
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The natural function of the malaria parasite’s chloroquine resistance transporter

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