Identification of peripheral neural circuits that regulate heart rate using optogenetic and viral vector strategies

The wiring of peripheral neural circuits that regulate heart rate is poorly understood. In this study, authors used tissue clearing for high-resolution characterization of nerves in the heart in 3D and transgenic and novel viral vector approaches to identify peripheral parasympathetic and sympatheti...

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Autores principales:	Pradeep S. Rajendran, Rosemary C. Challis, Charless C. Fowlkes, Peter Hanna, John D. Tompkins, Maria C. Jordan, Sarah Hiyari, Beth A. Gabris-Weber, Alon Greenbaum, Ken Y. Chan, Benjamin E. Deverman, Heike Münzberg, Jeffrey L. Ardell, Guy Salama, Viviana Gradinaru, Kalyanam Shivkumar
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/e62e7c209ae04211ac168bacbbdd12fb
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spelling	oai:doaj.org-article:e62e7c209ae04211ac168bacbbdd12fb2021-12-02T14:40:18ZIdentification of peripheral neural circuits that regulate heart rate using optogenetic and viral vector strategies10.1038/s41467-019-09770-12041-1723https://doaj.org/article/e62e7c209ae04211ac168bacbbdd12fb2019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09770-1https://doaj.org/toc/2041-1723The wiring of peripheral neural circuits that regulate heart rate is poorly understood. In this study, authors used tissue clearing for high-resolution characterization of nerves in the heart in 3D and transgenic and novel viral vector approaches to identify peripheral parasympathetic and sympathetic neuronal populations involved in heart rate control in mice.Pradeep S. RajendranRosemary C. ChallisCharless C. FowlkesPeter HannaJohn D. TompkinsMaria C. JordanSarah HiyariBeth A. Gabris-WeberAlon GreenbaumKen Y. ChanBenjamin E. DevermanHeike MünzbergJeffrey L. ArdellGuy SalamaViviana GradinaruKalyanam ShivkumarNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Pradeep S. Rajendran Rosemary C. Challis Charless C. Fowlkes Peter Hanna John D. Tompkins Maria C. Jordan Sarah Hiyari Beth A. Gabris-Weber Alon Greenbaum Ken Y. Chan Benjamin E. Deverman Heike Münzberg Jeffrey L. Ardell Guy Salama Viviana Gradinaru Kalyanam Shivkumar Identification of peripheral neural circuits that regulate heart rate using optogenetic and viral vector strategies
description	The wiring of peripheral neural circuits that regulate heart rate is poorly understood. In this study, authors used tissue clearing for high-resolution characterization of nerves in the heart in 3D and transgenic and novel viral vector approaches to identify peripheral parasympathetic and sympathetic neuronal populations involved in heart rate control in mice.
format	article
author	Pradeep S. Rajendran Rosemary C. Challis Charless C. Fowlkes Peter Hanna John D. Tompkins Maria C. Jordan Sarah Hiyari Beth A. Gabris-Weber Alon Greenbaum Ken Y. Chan Benjamin E. Deverman Heike Münzberg Jeffrey L. Ardell Guy Salama Viviana Gradinaru Kalyanam Shivkumar
author_facet	Pradeep S. Rajendran Rosemary C. Challis Charless C. Fowlkes Peter Hanna John D. Tompkins Maria C. Jordan Sarah Hiyari Beth A. Gabris-Weber Alon Greenbaum Ken Y. Chan Benjamin E. Deverman Heike Münzberg Jeffrey L. Ardell Guy Salama Viviana Gradinaru Kalyanam Shivkumar
author_sort	Pradeep S. Rajendran
title	Identification of peripheral neural circuits that regulate heart rate using optogenetic and viral vector strategies
title_short	Identification of peripheral neural circuits that regulate heart rate using optogenetic and viral vector strategies
title_full	Identification of peripheral neural circuits that regulate heart rate using optogenetic and viral vector strategies
title_fullStr	Identification of peripheral neural circuits that regulate heart rate using optogenetic and viral vector strategies
title_full_unstemmed	Identification of peripheral neural circuits that regulate heart rate using optogenetic and viral vector strategies
title_sort	identification of peripheral neural circuits that regulate heart rate using optogenetic and viral vector strategies
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/e62e7c209ae04211ac168bacbbdd12fb
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Identification of peripheral neural circuits that regulate heart rate using optogenetic and viral vector strategies

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