Probiotics Improve Gastrointestinal Function and Life Quality in Pregnancy

We studied whether probiotics were beneficial for hormonal change-associated dysbiosis, which may influence the enteric nervous system and GI function during early pregnancy. The study was 16 days consisting of two cycles of six daily probiotics mainly <i>Lactobacillus</i> and 2 days wit...

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Autores principales:	Albert T. Liu, Shuai Chen, Prasant Kumar Jena, Lili Sheng, Ying Hu, Yu-Jui Yvonne Wan
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	GI function intestinal motility fecal microbiota dysbiosis bile acids metabolomics Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/e6329a8d6f17434a84b7c64df5c9c288
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spelling	oai:doaj.org-article:e6329a8d6f17434a84b7c64df5c9c2882021-11-25T18:35:24ZProbiotics Improve Gastrointestinal Function and Life Quality in Pregnancy10.3390/nu131139312072-6643https://doaj.org/article/e6329a8d6f17434a84b7c64df5c9c2882021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/3931https://doaj.org/toc/2072-6643We studied whether probiotics were beneficial for hormonal change-associated dysbiosis, which may influence the enteric nervous system and GI function during early pregnancy. The study was 16 days consisting of two cycles of six daily probiotics mainly <i>Lactobacillus</i> and 2 days without probiotics. Daily surveys were conducted to monitor GI function and life quality. A subset of the participants who contributed fecal specimens was used for microbiota metagenomic sequencing, metabolomics, and quantification of bacterial genes to understand potential underlying mechanisms. Statistical analyses were done by generalized linear mixed-effects models. Thirty-two obstetric patients and 535 daily observations were included. The data revealed that probiotic supplementation significantly reduced the severity of nausea, vomiting, constipation, and improved life quality. Moreover, a low copy number of fecal <i>bsh</i> (bile salt hydrolase), which generates free bile acids, was associated with high vomiting scores and probiotic intake increased fecal <i>bsh</i>. In exploratory analysis without adjusting for multiplicity, a low fecal α-tocopherol, as well as a high abundance of <i>Akkemansia muciniphila</i>, was associated with high vomiting scores and times, respectively. The potential implications of these biomarkers in pregnancy and GI function are discussed. Probiotics likely produce free bile acids to facilitate intestinal mobility and metabolism.Albert T. LiuShuai ChenPrasant Kumar JenaLili ShengYing HuYu-Jui Yvonne WanMDPI AGarticleGI functionintestinal motilityfecal microbiotadysbiosisbile acidsmetabolomicsNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 3931, p 3931 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	GI function intestinal motility fecal microbiota dysbiosis bile acids metabolomics Nutrition. Foods and food supply TX341-641
spellingShingle	GI function intestinal motility fecal microbiota dysbiosis bile acids metabolomics Nutrition. Foods and food supply TX341-641 Albert T. Liu Shuai Chen Prasant Kumar Jena Lili Sheng Ying Hu Yu-Jui Yvonne Wan Probiotics Improve Gastrointestinal Function and Life Quality in Pregnancy
description	We studied whether probiotics were beneficial for hormonal change-associated dysbiosis, which may influence the enteric nervous system and GI function during early pregnancy. The study was 16 days consisting of two cycles of six daily probiotics mainly <i>Lactobacillus</i> and 2 days without probiotics. Daily surveys were conducted to monitor GI function and life quality. A subset of the participants who contributed fecal specimens was used for microbiota metagenomic sequencing, metabolomics, and quantification of bacterial genes to understand potential underlying mechanisms. Statistical analyses were done by generalized linear mixed-effects models. Thirty-two obstetric patients and 535 daily observations were included. The data revealed that probiotic supplementation significantly reduced the severity of nausea, vomiting, constipation, and improved life quality. Moreover, a low copy number of fecal <i>bsh</i> (bile salt hydrolase), which generates free bile acids, was associated with high vomiting scores and probiotic intake increased fecal <i>bsh</i>. In exploratory analysis without adjusting for multiplicity, a low fecal α-tocopherol, as well as a high abundance of <i>Akkemansia muciniphila</i>, was associated with high vomiting scores and times, respectively. The potential implications of these biomarkers in pregnancy and GI function are discussed. Probiotics likely produce free bile acids to facilitate intestinal mobility and metabolism.
format	article
author	Albert T. Liu Shuai Chen Prasant Kumar Jena Lili Sheng Ying Hu Yu-Jui Yvonne Wan
author_facet	Albert T. Liu Shuai Chen Prasant Kumar Jena Lili Sheng Ying Hu Yu-Jui Yvonne Wan
author_sort	Albert T. Liu
title	Probiotics Improve Gastrointestinal Function and Life Quality in Pregnancy
title_short	Probiotics Improve Gastrointestinal Function and Life Quality in Pregnancy
title_full	Probiotics Improve Gastrointestinal Function and Life Quality in Pregnancy
title_fullStr	Probiotics Improve Gastrointestinal Function and Life Quality in Pregnancy
title_full_unstemmed	Probiotics Improve Gastrointestinal Function and Life Quality in Pregnancy
title_sort	probiotics improve gastrointestinal function and life quality in pregnancy
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/e6329a8d6f17434a84b7c64df5c9c288
work_keys_str_mv	AT alberttliu probioticsimprovegastrointestinalfunctionandlifequalityinpregnancy AT shuaichen probioticsimprovegastrointestinalfunctionandlifequalityinpregnancy AT prasantkumarjena probioticsimprovegastrointestinalfunctionandlifequalityinpregnancy AT lilisheng probioticsimprovegastrointestinalfunctionandlifequalityinpregnancy AT yinghu probioticsimprovegastrointestinalfunctionandlifequalityinpregnancy AT yujuiyvonnewan probioticsimprovegastrointestinalfunctionandlifequalityinpregnancy
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Probiotics Improve Gastrointestinal Function and Life Quality in Pregnancy

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